Membrane traffic in myelinating oligodendrocytes

Microscopy Research and Technique

Volumn 52, Issue 6, 2001, Pages 656-671

  Krämer, Eva Maria ^a   Schardt, Anke ^a   Nave, Klaus Armin ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Disease; Membrane domains; Mistrafficking; Myelin assembly; Protein sorting; Vesicle trafficking

Indexed keywords

CELL MEMBRANES; SORTING;

CENTRAL NERVOUS SYSTEMS; MEMBRANE DOMAIN; MISTRAFFICING; MYELIN ASSEMBLY; MYELIN SHEATHS; OLIGODENDROCYTES; PROTEIN SORTING; SUBDOMAIN; SYNTHESISED; VESICLE TRAFFICKING;

PROTEINS;

CELLUBREVIN; LIPID; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN PROTEIN; PROTEOLIPID PROTEIN; RAB PROTEIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN;

CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASE; EXOCYTOSIS; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; MEMBRANE TRANSPORT; MYELIN SHEATH; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PELIZAEUS MERZBACHER DISEASE; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; TRANSCYTOSIS;

EID: 0035869494     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.1050     Document Type: Review

References (148)

1. Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH. 1999. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol 146:765-776.
2. Agard DA. 1993. To fold or not to fold.. Science 260:1903-1904.
3. Ainger K, Avossa D, Diana AS, Barry C, Barbarese E, Carson JH. 1997. Transport and localization elements in myelin basic protein mRNA. J Cell Biol 138:1077-1087.
4. Ainger K, Avossa D, Morgan F, Hill SJ, Barry C, Barbarese E, Carson JH. 1993. Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes. J Cell Biol 123: 431-441.
5. Allinquant B, Staugaitis SM, D'Urso D, Colman DR. 1991. The ectopic expression of myelin basic protein isoforms in shiverer oligodendrocytes: implications for myelinogenesis. J Cell Biol 113: 393-403.
6. Arroyo EJ, Scherer SS. 2000. On the molecular architecture of myelinated fibers. Histochem Cell Biol 113:1-18.
7. Barbarese E, Brumwell C, Kwon S, Cui H, Carson JH. 1999. RNA on the road to myelin. J Neurocytol 28:263-270.
8. Benjamins J A, Smith M. 1984. Metabolism of myelin. In: Morell P, editor. Myelin. New York: Plenum Press, pp 225-258.
9. Benjamins JA, Jones M Morell P. 1976. Appearance of newly synthesized protein in myelin of young rats. J Neurochem 24:1117-1122.
10. Bo L, Quarles RH, Fujita N, Bartoszewicz Z, Sato S, Trapp BD. 1995. Endocytic depletion of L-MAG from CNS myelin in quaking mice. J Cell Biol 131:1811-1820.
11. Boison D, Stoffel W. 1994. Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid-protein deficient mice. Proc Natl Acad Sci USA 91:11709-11713.
12. Bongarzone ER, Campagnoni CW, Kampf K, Jacobs EC, Handley VW, Schonmann V, Campagnoni AT. 1999. Identification of a new exon in the myelin proteolipid protein gene encoding novel protein isoforms that are restricted to the somata of oligodendrocytes and neurons.J Neurosci 19:8349-8357.
13. Bosio A, Bincek E, Stoffel W. 1996. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis. Proc Natl Acad Sci USA 93:13280-13285.
14. Bouverat BP, Krüger WH, Coetzee T, Bansal R, Pfeiffer SE. 2000. Expression of rab GTP-binding proteins during oligodendrocyte differentiation in culture. J Neurosci Res 59:446-543.
15. Bradke F, Dotti CG. 1998. Membrane traffic in polarized neurons. Biochim Biophys Acta 1404:245-258.
16. Braun PE, Horvath E, Yong VW, Bernier L. 1990. Identification of GTP-binding proteins in myelin and oligodendrocyte membranes. J Neurosci Res 26:16-23.
17. Braun PE, Sandillon F, Edwards A, Matthieu JM, Privat A. 1988. Immunocytochemical localization by electron microscopy of 2′3′-cyclic nucleotide 3′-phosphodiesterase in developing oligodendrocytes of normal and mutant brain. J Neurosci 8:3057-3066.
18. Bronstein JM, Tiwari-Woodruff S, Buznikov AG, Stevens DB. 2000. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. J Neurosci Res 59:706-711.
19. Brophy PJ, Boccaccio GL, Coleman DR. 1993. The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes. Trends Neurosci 16:515-521.
20. Brown DA, London E. 1998. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111-136.
21. Brown DA, London E. 2000. Structure and function of sphingolipid-and cholesterol-rich membrane rafts. J Biol Chem 275:17221-17224.
22. Brown MC, Besio-Moreno M, Bongarzone ER, Cohen PD, Soto EF, Pasquini JM. 1993. Vesicular transport of myelin proteolipid and cerebroside sulfates to the myelin membrane. J Neurosci Res 35: 402-408.
23. Brown RE. 1998. Sphingolipid organization in biomembranes: what physical studies of model membranes reveal. J Cell Sci 111:1-9.
24. Brunner C, Lassmann H, Waehneldt TV, Matthieu JM, Linington C. 1989. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J Neurochem 52:296-304.
25. Burcelin R, Rodriguez-Gabin AG, Charron MJ, Almazan G, Larocca JN. 1997. Molecular analysis of the monomeric GTP-binding proteins of oligodendrocytes. Brain Res Mol Brain Res 50:9-15.
26. Burkhart T, Caimi L, Siegrist, HP, Herschkowitz NN, Wiesmann UN. 1982. Vesicular transport of sulfatide in the myelinating mouse brain. J Biol Chem 257:3151-3156.
27. Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. 1985. Identification of two lysosomal membrane glycoproteins. J Cell Biol 101:85-95.
28. Cheong KH, Zacchetti D, Schneeberger EE, Simons K. 1999. VIP17/ MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc Natl Acad Sci USA 96:6241-6248.
29. Coco S, Raposo G, Martinez S, Fontaine JJ, Takamori S, Zahraoui A, Jahn R, Matteoli M, Louvard D, Galli T. 1999. Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/ VAMP7 in neuronal cells: evidence for a novel membrane compartment. J Neurosci 19:9803-9812.
30. Coetzee T, Suzuki K, Nave KA, Popko B. 1999. Myelination in the absence of galactolipids and proteolipid proteins. Mol Cell Neurosci 14:41-51.
31. Coetzee T, Fujita Nn, Dupree J, Shi R, Blight A, Suzuki K, Suzuki K, Popko B. 1996. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability. Cell 86:209-219.
32. Coleman DR, Kreibich G, Frey AB, Sabatini DD. 1982. Synthesis and incorporation of myelin polypeptides into CNS myelin. J Cell Biol 95:598-608.
33. Compans RW. 1995. Virus entry and release in polarized epithelial cells. Curr Top Microbiol Immunol 202:209-219
34. Deschenes SM, Walcott JL, Wexler TL, Scherer SS, Fischbeck KH. 1997. Altered trafficking of mutant connexin32. J Neurosci 17: 9077-9084.
35. deVries H, deJonge JC, Schrage C, van der Haar ME, Hoeckstra D. 1997. Differential and cell development-dependent localization of myelin mRNAs in oligodendrocytes. J Neurosci Res 47:479-488.
36. deVries H, Schrage C, Hoeckstra D. 1998. An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingo-lipid-enriched myelin membrane is the target of a basolateral-type pathway. Mol Biol Cell 9:599-609.
37. deWaegh SM, Lee VM, Brady ST. 1992. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 68:451-463.
38. Dubois-Dalcq M, Behar T, Hudson L, Lazzarini RA. 1986. Emergence of three myelin proteins in oligodendrocytes cultured without neurons. J Cell Biol 102:384-392.
39. d'Urso D, Prior R, Greiner-Petter R, Gabreels-Festen AA, Müller HW. 1998. Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22. J Neurosci 18:731-740.
40. Filbin MT. 1995. Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration? Curr Opin Neurobiol 5:588-595.
41. Frank M. 2000. MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond. Prog Neurobiol 60:531-544.
42. Frank M, van der Haar ME, Schaeren-Wiemers N, Schwab ME. 1998. rMAL is a glycosphingolipid-associated protein of myelin and apical membranes of epithelial cells in kidney and stomach. J Neurosci 18:4901-4913.
43. Friedrich VF, Centor D, Chambers J, Amheiter H, Lazzarini RA. 1989. Expression of exogenous glycoprotein genes in oligodendrocytes of transgenic mice. Ann NY Acad Sci 605:262-269.
44. Galli T, Zahraoui A, Vaidyanathan W, Raposo G, Tian JM, Karin M, Niemann H, Louvard D. 1998. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell 9:1437-1448.
45. Garcia-Ladona FJ, Huss Y, Frey P, Ghandour MS. 1997. Oligodendrocytes express different isoforms of β-amyloid precursor protein in chemically defined cell culture conditions: in situ hybridization and immunocytochemical detection. J Neurosci Res 50:50-61.
46. García-Mata R, Bebök Z, Sorscher EJ, Sztul ES. 1999. Characterization and Dynamics of Aggresome Formation by a Cytosolic GFP-Chimera. J Cell Biol 146:1239-1254.
47. Gaut JR, Hendershot LM. 1993. The modification and assembly of proteins in the endoplasmic reticulum. Curr Opin Cell Biol 5:589-595.
48. Ghandour MS, Skoff RP. 1991. In situ hybridization analysis of mRNAs for carbonic anhydrase II and myelin basic protein: expression in developing cultured glial cells. Glia 4:1-10.
49. Gonzalez L Jr, Scheller R H. 1999. Regulation of membrane trafficking: Structural insights from a Rah/effector complex. Cell 96:755-758.
50. Gould RM, Freund CM, Barbarese E. 1999. Myelin-associated oligodendrocytic basic protein mRNAs reside at different subcellular locations. J Neurochem 73:1913-24.
51. Gow A, Friedrich VL, Lazzarini RA. 1994b. Many naturally occuring mutations of myelin proteolipid protein impair its intracellular transport. J Neurosci Res 37:574-583.
52. Gow A, Lazzarini RA. 1996. A cellular mechanism governing the severity of Pelizaeus-Merzbacher disease. Nature Gen 13:422-428.
53. Gow A, Friedrich VL, Lazzarini RA. 1994a. Intracellular transport and sorting of the oligodendrocyte transmembrane proteolipid protein. J Neurosci Res 37:563-573.
54. Gow A, Southwood CM, Lazzarini RA. 1998. Disrupted proteolipid trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. J Cell Biol 140:925-934.
55. Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA. 1999. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11null mice. Cell 99: 649-59.
56. Griffiths G, Rottier P. 1992. Cell biology of viruses that assemble along the biosynthetic pathway. Semin Cell Biol 3:367-381.
57. Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA. 1998a. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280:1610-1613.
58. Griffiths IR, Klugmann M, Anderson TJ, Thomson C Vouyiouklis D, Nave KA. 1998b. Current concepts of PLP and its role in the nervous system. Microsc Res Tech 41:344-358.
59. Hay JC, Scheller R. 1997. SNAREs and NSF in targeted membrane fusion. Curr Opin Cell Biol 9:505-512.
60. Hemar A, Olivo JC, Williamson E, Saffrich R, Dotti CG. 1997. Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons. J Neurosci 17:9026-9034
61. Hepp R, Perraul M, Chasserot-Golaz S, Galli T, Aunis D, Langley K, Grant NJ. 1999. Cultured glial cells express the SNAP-25 analogue SNAP-23. Glia 27:181-187.
62. Holz A, Schaeren-Wiemers N, Schaefer C, Pott U, Collelo RJ, Schwab ME. 1996. Molecular and developmental characterization of novel cDNAs of the myelin-associated oligodendrocytic basic protein. J Neurochem 16:467-477.
63. Huber LA, Madison DL, Simons K, Pfeiffer SE. 1994. Myelin membrane biogenesis by oligodendrocytes. Developmental regulation of low molecular weight GTP-binding proteins. FEBS Letters 347: 273-278.
64. Hudson LD, Friedrich VL, Behar T, Dubois-Dalcq M, Lazzarini RA. 1989. The initial events in myelin synthesis: orientation of proteolipid protein in the plasmamembrane of cultured oligodendrocytes. J Cell Biol 109:717-727.
65. Jacobson K, Dietrich C. 1999. Looking at lipid rafts? Trends Cell Biol 9:87-91.
66. Jahn R, Südhof TC. 1994. Synaptic vesicles and exocytosis. Annu Rev Neurosci 17:219-246.
67. Jahn R, Südhof TC. 1999. Membrane fusion and exocytosis. Annu Rev Biochem 68:863-911.
68. Johnston JA, Ward CL, Kopito RR. 1998. Aggresomes: a cellular response to misfolded proteins J. Cell Biol 143:1883-1898
69. Jung M, Krämer EM, Grzenkowski M, Tang K, Blakemore W, Aguzzi A, Khazaie K, Chlichlia K, von Blankenfeld G, Kettenmann H, Trotter J. 1995. Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo. Eur J Neurosci 7: 1245-1265.
70. Jung M, Sommer I, Schachner M, Nave KA. 1996. Monoclonal antibody O10 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP Misfolding underlies dysmyelination in mutant mice. J Neurosci 16:7920-7929.
71. Keller MP, Chance PF. 1999. Inherited peripheral neuropathy. Semin Neurol 19:353-362
72. Kim T, Pfeiffer SE. 1999. Myelin glycosphingolipid/cholesterol-enriched microdomains selectively sequester the non-compact myelin proteins CNP and MOG. J Neurocytol 28:281-293.
73. Kim T, Fiedler K, Madison DL, Krueger WH, Pfeiffer SE. 1995. Cloning and characterization of MVP17: A developmentally regulated myelin protein in oligodendrocytes. J Neurosci Res 42: 413-422.
74. Klugmann M, Schwab MH, Puehlhofer A, Schneider A, Zimmermann F, Griffiths IR, Nave KA. 1997. Assembly of CNS myelin in the absence of proteolipid-protein. Neuron 18:59-70.
75. Knapp PE, Skoff RP, Redstone DW. 1986. Oligodendroglial cell death in jimpy mice: An explanation for the myelin deficit. J Neurosci 6:2813-2822.
76. Krämer EM, Koch T, Niehaus A, Trotter J. 1997. Oligodendrocytes direct glycosyl phosphatidylinositol-anchored proteins to the myelin sheath in glycosphingolipid-rich complexes. J Biol Chem 272:8937-8945.
77. Krämer EM, Klein C, Koch T, Boytinck M, Trotter J. 1999. Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinaase activation during myelination. J Biol Chem 274:29042-29049.
78. Lafont F, Verkade P, Galli T, Wimmer C, Louvard D, Simons K. 1999. Raft association of SNAP receptors acting in apical trafficking in Madi-Darby canine kidney cells. Proc Natl Acad Sci USA 96: 3734-3738.
79. Langlet C, Bernard AM, Drevot P, He HT. 2000. Membrane rafts and signaling by the multichain immune recognition receptors. Curr Opin Immunol 12:250-255.
80. Larocca JN, Golly F, Ledeen RW. 1991. Detection of G proteins in purified bovine brain myelin. J Neurochem 57:30-38.
81. Ledesma MD, Brugger B, Sunning FT, Wieland FT, Dotti CG. 1999. Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes. EMBO J 18:1761-1771.
82. Lees MB, Brostoff SW. 1984. Proteins of myelin. In: Morell P, editor. Myelin. New York: Plenum Press, p 197-217.
83. Li J, Hertzberg EL, Nagy JI. 1997. Connexin32 in oligodendrocytes and association with myelinated fibers in mouse and rat brain. J Comp Neurol 379:571-591.
84. LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI. 1995. Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Nat Acad Sci USA 92:10369-10373.
85. Low SH, Chapin SJ, Weimbs T, Kömüves LG, Bennet MK, Mostov KE. 1996. Differential localisation of syntaxin isoforms in polarized Madin-Darby canine kidney cells. Mol Biol Cell 7:2007-2018.
86. Low SH, Chapin SJ, Wimmer C, Whiteheart SW, Kömüves LG, Mostov KE, Weimbs T. 1998a. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. J Cell Biol 141:1503-1513.
87. Low SH, Roche PA, Anderson HA, van Ijzendoorn SC, Zhang M, Mostov KE, Weimbs T. 1998b. Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. J Biol Chem 273:3422-3430.
88. Lubetzki C, Demerens C, Anglade P, Villarroya H, Frankfurter A, Lee VM, Zalc B. 1993. Even in culture, oligodendrocytes myelinate solely axons. Proc Natl Acad Sci USA 90:6820-6824.
89. Madison DE, Pfeiffer SE. 1997. Do secretory pathway SNARE proteins mediate myelinogenesis? In: Juurlink et al., eds. Cell biology and pathology of myelin. New York: Plenum Press, p 145-154.
90. Madison DL, Krueger WH, Cheng D, Trapp BD, Pfeiffer SE. 1999. SNARE complex proteins, including the cognate pair VAMP-2 and syntaxin-4 are expressed in cultured oligodendrocytes. J Neurochem 72:988-998.
91. Madison DL, Krüger WH, Kim T, Pfeiffer SE. 1996. Differential expression of rab3 isoforms in oligodendrocytes and astrocytes. J Neurosci Res 45:258-268.
92. Mellman I, Warren G. 2000. The road taken: past and future foundations of membrane traffic. Cell 100:99-112.
93. Minuk J, Braun PE. 1996. Differential intracellular sorting of the myelin-associated glycoprotein isoforms. J Neurosci Res 44:411-420.
94. Montecucco C. 1998. Protein toxins and membrane transport. Curr Opin Cell Biol 10:530-536.
95. Monta K, Sasaki H, Fujimoto K, Furuse M, Tsukita S. 1999. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol 145:579-588.
96. Mostov KE, Cardone MH. 1995. Regulation of protein traffic in polarized epithelial cells. BioEssays 17:129-138.
97. Mostov KE, Verges M, Altschuler Y. 2000. Membrane traffic in polarised epithelial cells. Curr Opin Cell Biol 12:483-490.
98. Müller HW. 2000. Tetraspan myelin protein PMP22 and demyelinating peripheral neuropathies: new facts and hypotheses. Glia 29: 182-185.
99. Naef R, Adlkofer K, Lescher B, Suter U. 1997. Abberant protein trafficking in Trembler suggests a disease mechanism for hereditary human peripheral neuropathies. Mol Cell Neurosci 9:13-25.
100. Naef R, Suter U. 1999. Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies. Neurobiol Dis 6:1-14.
101. Nave KA, Lai C, Bloom FE, Milner RJ. 1987. Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. Proc Natl Acad Sci USA 84:5665-5669.
102. Neri CL, Duchala CS, Macklin WB. 1997. Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes. J Neurisci Res 50:769-780.
103. Niemann S, Sereda MW, Rossner M, Stewart H, Suter U, Meinck HM, Griffiths IR, Nave KA. 1999. The "CMT rat": peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22. Ann NY Acad Sci 883:254-261.
104. Norton WT, Cammer W. 1984. Isolation and characterization of myelin. In: Morell P, editor. Myelin. New York: Plenum Press, p 147-195.
105. Novick P, Zerial M. 1997. The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol 9:496-504.
106. Nussbaum JL, Roussel G. 1983. Immunocytochemical demonstration of the transport of myelin proteins through the golgi apparatus. Cell Tissue Res 234:547-559.
107. Olson AL, Knight JB, Pessin JE. 1997. Syntaxin-4, VAMP-2, and/or VAMP-3/cellubrevin are fuctional target membrane and vesicle SNAP receptors for insulin stimulated GLUT-4 translocation in adipocytes. Mol Cell Biol 17:2425-2435.
108. Parton RG, Way M, Zorzi N, Stang E. 1997. Caveolin-3 associates with developing T-tubules during muscle differentiation. J Cell Biol 136:137-154.
109. Pasquini JM, Guarna MM, Besio-Moreno MA, Iturregui MT, Oteiza PI, Soto EF. 1989. Inhibition of the synthesis of glycosphingolipids affects the translocation of proteolipid protein to the myelin membrane. J Neurosci Res 22:289-296.
110. Pedraza L, Fidler L, Staugaitis SM, Coleman DR. 1997. The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelination. Neuron 18:579-589.
111. Pessin JE, Thurmond DC, Elmendorf JS, Coker KJ, Okada S. 1999. Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. J Biol Chem 274:2593-2596.
112. Pfeiffer SE, Warrington AE, Bansal R. 1993. The oligodendrocyte and its many cellular processes. Trends Cell Biol 3:191-197.
113. Popot JL, Pham Dinh D, Dautigny A. 1991. Major myelin proteolipid: the 4-alpha-helix topology. J Membr Biol 120:233-246.
114. Puertollano R, Martin-Belmonte F, Millan J, del Carmen de Marco M, Albar JP, Kremer L, Alonso MA. 1999. The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby Canine Kidney cells. J Cell Biol 145:141-151.
115. Ravichandran V, Chawla A, Roche PA. 1996. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J Biol Chem 271:13300-13303.
116. Richter-Landsberg C. 2000. The oligodendroglia cytoskeleton in health and disease. J Neurosci Res 2000 59:11-18.
117. Rothman JE. 1994. Mechanisms of intracellular protein transport. Nature 372:55-63.
118. Roussel G, Neskovic NM, Trifilieff E, Artault JC, Nussbaum JL. 1987. Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain. J Neurocytol 16:195-204.
119. Scales SJ, Bock JB, Scheller RH. 2000. The specifics of membrane fusion. Nature 407:144-146.
120. Schachner M, Bartsch U. 2000. Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 29:154-165.
121. Schaeren-Wiemers N, Valenzuela DM, Frank M, Schwab ME. 1995. Characterization of a rat gene rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin. J Neurosci 15:5753-5764.
122. Schimmöller F, Simon I, Pfeffer SR. 1998. Rab GTPases, directors of vesicle docking. J Biol Chem 273:22161-22164.
123. Schwob VS, Clark HB, Agrawal D, Agrawal HG. 1985. Electron microscopic immunocytochemical localization of myelin proteolipid protein and myelin basic protein in rat brain during myelination. J Neurochem 45:559-571.
124. Simons K, Zerial M. 1993. Rab proteins and the road maps for intracellular transport. Neuron 11:789-799.
125. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-572.
126. Simons M, Krämer EM, Thiele C, Stoffel W, Trotter J. 2000. Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. J Cell Biol 151:1-13.
127. Sinoway MP, Kitagawa K, Timsit S, Hashim GA, Coleman DR. 1994. Proteolipid interactions in transfectants: implications for myelin assembly. J Neurosci Res 37:551-562.
128. Staugaitis SM, Smith PR, Coleman DR. 1990. Expression of myelin basic protein isoforms in nonglial cells. J Cell Biol 110:1719-1727.
129. Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH. 1998. Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem 273:34171-34179.
130. Südhof TC. 1995. The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375:645-653.
131. Tait S, Gunn-Moore F, Collinson JM, Huang J, Lubetzki C, Pedraza L, Sherman DL, Colman DR, Brophy PJ. 2000. An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction. J Cell Biol 150:657-666.
132. Tansey FA, Zhang H, Cammer W. 1996. Expression of carbonic anhydrase II mRNA and protein in oligodendrocytes during toxic demyelination in the young adult mouse. Neurochem Res 21:411-416.
133. Thomson CE, Montague P, Jung M, Nave KA, Griffiths IR. 1997. Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins. Glia 20:322-332.
134. Tobler AR, Notterpek L, Naef R, Taylor V, Suter U, Shooter EM. 1999. Transport of trembler-j mutant peripheral myelin protein 22 is blocked in the intermediate compartment and affects the transport of the wild-type protein by direct interaction. J Neurosci 19:2027-2036.
135. Trapp BD. 1990. Myelin-associated glycoprotein: location and potential functions. Ann NY Acad Sci 605:29-43.
136. Trapp BD, Andrews SB, Cootauco C, Quartes RH. 1989. The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J Cell Biol 109:2417-2426.
137. Trapp BD, Nishiyama A, Cheng D, Macklin W. 1997. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol 137:459-468.
138. Trotter J, Klein C, Krämer EM. 2000. GPI-anchored proteins and glycosphingolipid-rich rafts: platforms for adhesion and signaling. Neuroscientist 6:271-284.
139. van der Haar ME, Visser HW, de Vries H, Hoeckstra D. 1998. Transport of proteolipid protein to the plasma membrane does not depend on glycosphingolipid cotransport in oligodendrocyte cultures. J Neurosci Res 51:371-381.
140. VanSlyke JK, Deschenes SM, Musil LS. 2000. Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins. Mol Biol Cell 11:1933-1946.
141. Waters MG, Pfefier SR. 1999. Membrane tethering in intracellular transport. Curr Opin Cell Biol 11:453-459.
142. Weimbs T, Stoffel W. 1992. Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP. Biochemistry 31:12289-12296.
143. Werner H, Jung M, Klugmann M, Sereda M, Griffiths IR, Nave KA. 1998. Mouse models of myelin diseases. Brain Pathol 8:771-793.
144. Whight PA, Duchala CS, Readhead C, Macklin WB. 1993. A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol 123:443-454.
145. Woodman P. 1998. Vesicle transport: More work for the Rabs? Curr Biol 8:R199-R201.
146. Wrabetz L, Feltri ML, Quattrini A, Imperiale D, Previtali S, D'Antonio M, Martini R, Yin X, Trapp BD, Zhou L, Chiu SY, Messing A. 2000. P0 glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol 148:1021-1033.
147. o protein. J Cell Biol 148:1009-1020.
148. Yool DA, Edgar JM, Montague P, Malcolm S. 2000. The proteolipid protein gene and myelin disorders in man and animal models. Hum Mol Genet 9:987-992.