Identification of a new exon in the myelin proteolipid protein gene encoding novel protein isoforms Thai are restricted to the somata of oligodendrocytes and neurons

Journal of Neuroscience

Volumn 19, Issue 19, 1999, Pages 8349-8357

  Bongarzone, Ernesto R ^a   Campagnoni, Celia W ^a   Kampf, Kathy ^a   Jacobs, Erin C ^a   Handley, Vance W ^a   Schonmann, Vilma ^a   Campagnoni, Anthony T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gene expression; Gene structure; Myelin protein genes; Myelin proteins; Neuronal genes; Protein targeting

Indexed keywords

GENE PRODUCT; ISOPROTEIN; MESSENGER RNA; PROTEOLIPID PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EXON; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MOUSE; MYELIN SHEATH; NEWBORN; NONHUMAN; NORTHERN BLOTTING; OLFACTORY SYSTEM; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION;

EID: 0033216282     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-19-08349.1999     Document Type: Article

References (42)

1. Anderson TJ, Schneider A, Barrie JA, Klugmann M, McCulloch MC, Kirkham D, Kyriakides E, Nave KA, Griffiths IR (1998) Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene. J Comp Neurol 394:506-519.
2. Bizzozero OA, Besio-Moreno M, Pasquini JM, Soto EF, Gomez CJ (1982) An electrophoretic analysis of proteolipids from different rat brain subcellular fractions. Biochim Biophys Acta 691:281-292.
3. Bongarzone ER, Foster LM, Byravan S, Verity AN, Landry CF, Schonmann V, Amur-Umarjee S, Campagnoni AT (1996) Conditionally immortalized neural cell lines: potential models for the study of neural cell function. Methods 10:489-500.
4. Bongarzone ER, Howard SG, Schonmann V, Campagnoni AT (1998a) Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation. J Neurosci 18:5344-5353.
5. Bongarzone ER, Foster L, Byravan S, Casaccia-Bonnefil P, Schonmann V, Campagnoni AT (1998b) Two neuronal cell lines expressing the Golli-MBP gene display differences in their in vitro survival and in their interaction with glia. J Neurosci Res 54:309-319.
6. Campagnoni CW, Garbay B, Micevych P, Pribyl T, Kampf K, Handley VW, Campagnoni AT (1992) DM20 mRNA splice product of the myelin proteolipid protein gene is expressed in the murine heart. J Neurosci Res 33:148-155.
7. Chan DS, Lees MB (1974) Gel electrophoresis studies of bovine brain white matter proteolipid and myelin proteins. Biochemistry 13:2704-2712.
8. Coetzee T, Suzuki K, Nave KA, Popko B (1999) Myelination in mice lacking galactolipids and proteolipid protein. J Neurochem 72[Suppl]: S45.
9. Gao WO, Heintz N, Hatten ME (1991) Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron 6:705-715.
10. Gardinier MV, Macklin WB (1988) Myelin proteolipid protein gene expression in jimpy and jimpy(msd) mice. J Neurochem 51:360-369.
11. Griffiths I, Klugmann M, Anderson T, Thomson C, Vouyiouklis D, Nave KA (1998a) Current concepts of PLP and its role in the nervous system. Microsc Res Tech 41:344-358.
12. Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA (1998b) Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280:1610-1613.
13. Griffiths IR (1996) Myelin mutants: model systems for the study of normal and abnormal myelination. Bioessays 18:789-797.
14. Griffiths IR, Montague P, Dickinson P (1995) The proteolipid protein gene. Neuropathol Appl Neurobiol 21:85-96.
15. Hudson LD, Nadon NL (1992) Amino acid substitutions in proteolipid protein that cause dysmyelination. In: Myelin: biology and chemistry (Martenson RE, ed), pp 677-702. Boca Raton, FL: CRC.
16. Ikenaka K, Kagawa T, Mikoshiba K (1992) Selective expression of DM-20, an alternatively spliced myelin proteolipid protein gene product, in developing nervous system and in nonglial cells. J Neurochem 58:2248-2253.
17. Jung M, Sommer I, Schachner M, Nave KA (1996) Monoclonal antibody 010 defines a conformationally sensitive cell-surface epitope of proteolipid protein (PLP): evidence that PLP misfolding underlies dysmyelination in mutant mice. J Neurosci 16:7920-7929.
18. Kamholz J, Sessa M, Scherer S, Vogelbacker H, Mokuno K, Baron P, Wrabetz L, Shy M, Pleasure D (1992) Structure and expression of proteolipid protein in the peripheral nervous system. J Neurosci Res 31:231-244.
19. Knapp PE (1996) Proteolipid protein: is it more than just a structural component of myelin? Dev Neurosci 18:297-308.
20. Landry CF, Ellison JA, Pribyl TM, Campagnoni C, Kampf K, Campagnoni AT (1996) Myelin basic protein gene expression in neurons: developmental and regional changes in protein targeting within neuronal nuclei, cell bodies, and processes. J Neurosci 16:2452-2462.
21. Landry CF, Pribyl TM, Ellison JA, Givogri MI, Kampf K, Campagnoni CW, Campagnoni AT (1998) Embryonic expression of the myelin basic protein gene: identification of a promoter region that targets transgene expression to pioneer neurons. J Neurosci 18:7315-7327.
22. Lepage P, Helynck G, Chu JY, Luu B, Sorokine O, Trifilieff E, Van Dorsselaer A (1986) Purification and characterization of minor brain proteolipids: use of fast atom bombardment-mass spectrometry for peptide sequencing. Biochimie 68:669-686.
23. Macklin WB, Campagnoni CW, Deininger PL, Gardinier MV (1987) Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res 18:383-394.
24. Macklin WB, Gardinier MV, Obeso Z (1990) Structure and expression of the mouse myelin proteolipid protein gene. Ann NY Acad Sci 605:183-193.
25. Nave KA, Milner RJ (1989) Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice. Crit Rev Neurobiol 5:65-91.
26. Nave KA, Lai C, Bloom FE, Milner RJ (1987) Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. Proc Natl Acad Sci USA 84:5665-5669.
27. Pribyl TM, Campagnoni C, Kampf K, Handley VW, Campagnoni AT (1996a) The major myelin protein genes are expressed in the human thymus. J Neurosci Res 45:812-819.
28. Pribyl TM, Campagnoni CW, Kampf K, Kashima T, Handley VW, McMahon J, Campagnoni AT (1996b) Expression of the myelin proteolipid protein gene in the human fetal thymus. J Neuroimmunol 67:125-130.
29. Puckett C, Hudson L, Ono K, Friedrich V, Benecke J, Dubois-Dalcq M, Lazzarini RA (1987) Myelin-specific proteolipid protein is expressed in myelinating Schwann cells but is not incorporated into myelin sheaths. J Neurosci Res 18:511-518.
30. Readhead C, Schneider A, Griffiths IR, Nave KA (1994) Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12:583-595.
31. Sakura JD (1981) Physical properties of bovine white matter proteolipid apoprotein-sodium dodecyl sulfate complexes. J Neurosci Res 6:689-700.
32. Sambrook J, Frisch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
33. Skoff RP (1995) Programmed cell death in the dysmyelinating mutants. Brain Pathol 5:283-288.
34. Skoff RP, Knapp PE (1990) Expression of the Jimpy phenotype in relation to proteolipid protein appearance. Ann NY Acad Sci 605:122-134.
35. Sorg BA, Smith M, Campagnoni AT (1987) Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice. J Neurochem 49:1146-1154.
36. Timsit S, Martinez S, Allinquant B, Peyron F, Puelles L, Zalc B (1995) Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J Neurosci 15:1012-1024.
37. Timsit SG, Bally-Cuif L, Colman DR, Zalc B (1992) DM-20 mRNA is expressed during the embryonic development of the nervous system of the mouse. J Neurochem 58:1172-1175.
38. Trifilieff E, Luu B, Nussbaum JL, Roussel G, Espinosa de los Monteros A, Sabatier JM, Van Rietschoten J (1986) A specific immunological probe for the major myelin proteolipid. Confirmation of a deletion in DM-20. FEBS Lett 198:235-239.
39. Weimbs T, Stoffel W (1992) Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP. Biochemistry 31:12289-12296.
40. Wight PA, Dobretsova A (1997) The first intron of the myelin proteolipid protein gene confers cell type-specific expression by a transcriptional repression mechanism in non-expressing cell types. Gene 201:111-117.
41. Yan Y, Lagenaur C, Narayanan V (1993) Molecular cloning of M6: identification of a PLP/DM20 gene family. Neuron 11:423-431.
42. Yan Y, Lagenaur C, Narayanan V (1996) Expression of members of the proteolipid protein gene family in the developing murine central nervous system. J Comp Neurol 370:465-478.