A differential role of extracellular signal-regulated kinase in stimulated PC12 pheochromocytoma cell movement

Experimental Cell Research

Volumn 263, Issue 2, 2001, Pages 254-264

  Ho, Wai chi ^a   Uniyal, Shashi ^a   Meakin, Susan O ^a,b   Morris, Vincent L ^a   Chan, Bosco M C ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Chemokinesis; Chemotaxis; ERK; Integrins; Nerve growth factor; PC12 cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYTOSKELETON PROTEIN; EPIDERMAL GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL MOTION; CELL STRAIN; CHEMOKINESIS; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0035864371     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5112     Document Type: Article

References (78)

1. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
2. Signal transduction by the neurotrophin receptors
3. Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor
4. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
5. Identification and characterization of novel substrates of Trk receptors in developing neurons
6. The signaling adaptor FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA
7. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
8. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
9. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
10. GTK, a src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway
11. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling
12. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells
13. Integrins: Versatility, modulation, and signaling in cell adhesion
14. PC12 cells overexpressing tissue plasminogen activator regenerate neurites to a greater extent and migrate faster than control cells in complex extracellular matrix
15. Cell migration: A physically integrated molecular process
16. Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
17. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein
18. Neural crest cell interactions with laminin: Structural requirements and localization of the binding site for α1β1 integrin
19. Specialized functional properties of the integrin α4 cytoplasmic domain
20. Sequential regulation of α4β1 and α5β1 integrin avidity by CC chemokines in monocytes: Implications for transendothelial chemotaxis
21. Integrin-associated protein stimulates α2β1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases
22. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
23. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
24. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
25. Regulation of chemotaxis by the platelet-derived growth factor receptor-β
26. R-Ras signals through specific integrin α cytoplasmic domains to promote migration and invasion of breast epithelial cells
27. The regulation of endothelial cell motility by p21 ras
28. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras
29. Regulation of cell motility by mitogen-activated protein kinase
30. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
31. trk-, Ras- and src-dependent
32. TrkA cross-linking mimics neuronal responses to nerve growth factor
33. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
34. An epitope on VLA-6 (α6β1) integrin involved in migration but not adhesion is required for extravasation of murine melanoma B16F1 cells in liver
35. Integrin-binding peptide in solution inhibits or enhances endothelial cell migration, predictably from cell adhesion
36. Modulation of in vivo migratory function of α2β1 integrin in mouse liver
37. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
38. Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor
39. ras activity and consequent prolonged ERK activity
40. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells
41. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
42. The nerve growth factor family of receptors
43. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength
44. Integrin - Ligand binding properties govern cell migration speed through cell - Substratum adhesiveness
45. A neuronal cell line (PC12) expresses two β1-class integrins-α1β1 and α3βl - That recognize different neurite outgrowth-promoting domains in laminin
46. Characterization of neural cell adhesion sites: Point contacts are the sites of interaction between integrins and the cytoskeleton in PC12 cells
47. Integrin in point contacts mediate cell spreading: Factors that regulate integrin accumulation in point contact vs. focal contact
48. α1β1 Integrin heterodimer functions as a dual laminin/collagen receptor in neural cells
49. A role for the SHP-2 tyrosine phosphatase in nerve growth factor-induced PC12 cell differentiation
50. Nerve growth factor stimulates tyrosine phosphorylation and activation of Src homology-containing protein-tyrosine phosphatase 1 in PC 12 cells
51. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation
52. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
53. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
54. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
55. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
56. Nerve growth factor-mediated activation of the mitogen-activated protein (MAP) kinase cascade involves a signaling complex containing B-Raf and HSP90
57. Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP
58. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
59. Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein
60. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extra-cellular sigual-regulated kinase and p38 mitogen-activated protein kinases
61. Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function
62. Phosphatidylinositol 3-kinase-independent singnal transduction pathway for platelet-derived growth factor-induced chemotaxis
63. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras
64. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
65. NGF and neutrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis
66. The pool of MAP kinase associated with microtubules is small but constitutively active
67. Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions
68. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
69. Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP
70. Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP
71. Regulation of motility and cytoskeletal organization of rat bladder carcinoma cells by cyclic AMP
72. Astrocyte process growth induction by actin breakdown
73. Cyclic AMP-induced shape changes of astrocytes are accompanied by rapid depolymerization of actin
74. 13 deficiency
75. 13
76. A role for Cdc42 in macrophage chemotaxis
77. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility
78. Directional guidance of neuronal migration in the olfactory system by the protein Slit