Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to γ-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 772-780

  Hsu, H C ^a   Shultz, L D ^a   Su, X ^a   Shi, J ^a   Yang, P A ^a   Relyea, M J ^a   Zhang, H G ^a   Mountz, J D ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM 137; GENE PRODUCT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; FEMALE; GAMMA IRRADIATION; GENE MUTATION; HEMATOPOIETIC CELL; HETEROZYGOTE; HOMOZYGOTE; MACROPHAGE; MALE; MITOSIS INHIBITION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; SEQUENCE HOMOLOGY; SPLEEN CELL; STRESS; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 0035863802     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.772     Document Type: Article

References (47)

1. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
2. "Viable motheaten" a new allele at the motheaten locus. I. Pathology
3. A protein tyrosine phosphatase with sequence similarity to the SH2 domain of the protein tyrosine kinase
4. Isolation of a src homology 2-containing tyrosine phosphatase
5. v) mutant mice. I. Analysis of development of prothymocytes early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells
6. Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice
7. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: A step toward defining the roles of protein tyrosine phosphatases in the regulation of hematopoietic cell differentiation and function
8. The stress response to ionizing radiation involves c-Abl-dependent phosphorylation of SHPTP1
9. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
10. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SHPTP1 in murine T cells
11. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation
12. Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand
13. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis
14. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis
15. Hematopoietic cell protein tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect
16. The tyrosine phosphatase SHP-1 influences thymocytes selection by setting TCR signaling thresholds
17. The use of 7-amino actinomycin D in identifying apoptosis: Simplicity of use and broad spectrum of application compared with other techniques
18. Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells: Comparison of seven mitochondrion-specific fluorochromes
19. Cell flow cytometry of fixed and unfixed bursal and thymic cells
20. Accelerated rate of mononuclear phagocyte production in vitro by splenocytes from autoimmune motheaten mice
21. v)
22. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: Detection of potential HCP substrates in GM-CSF signal transduction
23. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice
24. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptorassociated protein involved in the regulation of B cell signaling
25. Role of the mitochondrial permeability transition pore in apoptosis
26. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
27. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis
28. L function and induce apoptosis through cytochrome c-independent activation of caspases
29. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
30. Apoptosis in hematopoietic cells is associated with an extensive decreases in cellular phosphotyrosine content that can be inhibited by the tyrosine phosphatase antagonist pervanadate
31. The involvement of protein tyrosine kinase activity in a tumor necrosis factor resistance mechanism
32. The src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells
33. 1/S-phase border
34. Radiation down-regulates replication origin activity throughout the S phase in mammalian cells
35. Importance of DNA damage in the induction of apoptosis by ionizing radiation: Effect of the scid mutation and DNA ploidy on the radiosensitivity of murine lymphoid cell lines
36. Molecular mechanisms of ionizing radiation-induced apoptosis
37. Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines
38. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines
39. Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations
40. 1 arrest in two closely related human lymphoblast cell lines that differ in p53 status
41. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice
42. Participation of the Bcl-2 and Fas molecules in experimental apoptosis of spleen B lymphocytes
43. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase
44. Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation
45. Tissue and cell-specific expression of the p53-target genes: Bax, fas, mdm2 and waf1/p21, before and following, ionizing irradiation in mice
46. Involvement of the MKK6-p38 γ cascade in γ-radiation-induced cell cycle arrest
47. Interdependent regulation of intracellular acidification and SHP- in apoptosis