Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 1223-1232

  Kim, C ^a   Dinauer, M C ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CHEMOATTRACTANT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; IMMUNOGLOBULIN FC FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; RAC PROTEIN; RAC2 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NEUTROPHIL; NONHUMAN; OPSONIZATION; PERITONEUM CELL; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; SIGNAL TRANSDUCTION;

EID: 0035863735     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.1223     Document Type: Article

References (80)

1. NADPH oxidase: An update
2. Assembly of the phagocyte NADPH oxidase: Molecular of oxidase proteins
3. The phagocyte system and disorders of granulopoiesis and granulocyte function
4. phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase
5. phox and regulation of phagocytic NADPH oxidase activity
6. rac1
7. Regulation of phagocyte oxygen radical production by the GTP-binding protein rac 2
8. Rho GTPases and the actin cytoskeleton
9. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
10. Requirements for both Rac1 and Cdc42 in membrane raffling and phagocytosis in leukocytes
11. Deficiency of the hematopoietic cell-specific Rho-family GTPase, Rac2, is characterized by abnormalities in neutrophil function and host defense
12. Rho GTPases and signaling networks
13. Rho GTPases
14. Rac, a novel Ras-related family of proteins that are botulinum toxin substrates
15. A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells
16. The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments
17. Rac GTPase interacts with GAPs and target proteins through multiple effector sites
18. Characterization of RAC3, a novel member of the Rho family
19. phox interacts preferentially with Rac2 rather than Rac1
20. phox
21. Membrane association of Rac is required for high activity of the respiratory burst oxidase
22. phox
23. Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides
24. Function of wild-type or mutant Rac2 and Rapla GTpases in differentiated HL60 Cell NADPH oxidase activation
25. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
26. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils
27. Purification and characterization of rac2
28. Requirement for posttranslational processing of rac GTP-binding proteins for activation of human neutrophil NADPH oxidase
29. L expression while mediating survival and actin function in primary mast cells
30. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
31. Mouse Model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
32. A rapid, specific assay for superoxide release from phagocytes in small volumes of whole blood
33. Inhibition of Fcγ receptor-mediated phagocytosis by a nonphagocytic Fcγ receptor
34. phox into bone marrow cells rescues in host defense against Asperigillus fumigatus in murine X-linked chronic granulomatous disease
35. phox
36. Improvement of superoxide production in monocytes from patients with chronic granulomatous disease by recombinant cytokines
37. Priming of eosinophil and neutrophil migratory responses by interleukin 3 and interleukin 5
38. Long-term correction of phagocyte NADPH oxidase activity by retroviral-mediated gene transfer in murine X-linked chronic granulomatous disease
39. Chemoattractant signaling and leukocyte activation
40. Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav. and Rac1 in human mature T lymphocytes
41. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
42. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
43. p38 Mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation
44. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: Role in activation of reduced nicotinamide adenine dinucleotide oxidase
45. Importance of MEK in neutrophil microbicidal responsiveness
46. 2 and its mode of activation in human neutrophils by opsonized zymosan
47. Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38
48. A dominant negative mutation of the hematopoietic-specific RhoGTPase, Rac 2, is associated with a human phagocyte immunodeficiency
49. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
50. Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65
51. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers-for Rho-like proteins
52. Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42
53. Structural requirements for PAK activation by Rac GTPases
54. Signaling mechanisms in human neutrophils
55. A novel protein kinase target for the lipid second messenger phosphatidic acid
56. The syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils
57. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
58. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
59. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
60. Integrin signalling in neutrophils and macrophages
61. Fc receptor and complement receptor-mediated phagocytosis in host defence
62. The molecular dissection of Fcγ receptor mediated phagocytosis
63. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
64. Fcγ receptors in phagocytes
65. Modular components of phagocytosis
66. CR3 (Mac-1 αMβ2, CD11b/CD18) and FcγRIII cooperate in generation of a neutrophil respiratory burst: Requirement for FcγRII and tyrosine phosphorylation
67. Identification of two distinct mechanisms of phagocytosis controlled by different rho GTPases
68. Protein kinase C-β contributes to NADPH oxidase activation in neutrophils
69. Selective role for β-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells
70. p38 Mitogen-activated protein-kinase-dependent and-independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
71. p38 MAPK signalling cascades in inflammatory disease
72. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
73. Signaling from Ras to Rac and beyond not just a matter of GEFs
74. The small GTP-binding proteins Rac1 rand Cdc42 regulate the activity of the JNK/SAPK signaling pathway
75. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
76. Sphingosine blocks human polymorpho nuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation
77. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes
78. Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils
79. Fcγ receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: Role for p42MAPK in Fcγ receptor-stimulated TNF-α synthesis
80. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages