Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation

Blood

Volumn 93, Issue 2, 1999, Pages 686-693

  Raeder, Evelin M B ^b   Mansfield, Pamela J ^b   Hinkovska Galcheva, Vania ^b   Kjeldsen, Lars ^b   Shayman, James A ^b   Boxer, Laurence A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLYCINE; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE D; PROTEIN KINASE C; RAF PROTEIN; SPHINGANINE; SPHINGOSINE;

ARTICLE; CELL FRACTIONATION; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ERYTHROCYTE; HUMAN; HUMAN CELL; NEUTROPHIL; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; WESTERN BLOTTING;

EID: 0033555814     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.2.686     Document Type: Article

References (39)

1. Kinet JP: Antibody cell interactions: Fc receptors. Cell 57:351, 1989
2. de Haas M, Vossebeld PJM, von dem Borne AEGK, Roos D: Fcγ receptors of phagocytes. J Lab Clin Med 126:330, 1995
3. Silverstein SC, Greenberg S, Di Virgilio F, Steinberg TH: Phagocytosis, in William PE (ed): Fundamental Immunology. New York, NY, Raven, 1989, p 703
4. Liang L, Huang C-K: Activation of multiple protein kinases induced by cross-linking of FcγRII in human neutrophils. J Leukoc Biol 57:326, 1995
5. Suchard SJ, Mansfield PJ, Boxer LA, Shayman JA: Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils. Inhibition by ceramide. J Immunol 158:4961, 1997
6. Indik ZK, Park J-G, Hunter S, Schreiber AD: The molecular dissection of Fcγ receptor mediated phagocytosis. Blood 86:4389, 1995
7. Connelly PA, Farrell CA, Merenda JM, Conkyn MJ, Showell HJ: Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3). Biochem Biophys Res Commun 177:192, 1991
8. 2+ accumulation in Fcγ-receptor-mediated phagocytosis of human neutrophils. Biochem J (Tokyo) 117:1156, 1995
9. Hamada F, Aoki M, Akiyama T, Toyoshima K: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Proc Natl Acad Sci USA 90:6305, 1993
10. Santana C, Noris G, Espinoza B, Ortega E: Protein tyrosine phosphorylation in leukocyte activation through receptors for IgG. J Leukoc Biol 60:433, 1996
11. Denhardt DT: Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling. Biochem J 318:729, 1996
12. Knall C, Young S, Nick JA, Mette Buhl A, Worthen GS, Johnson GL: Interleukin-8 regulation of Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J Biol Chem 271:2832, 1996
13. Pawson T: Protein modules and signalling networks. Nature 373:573, 1995
14. Ueda Y, Hirai S-I, Osada S-I, Suzuki A, Mizuno K, Ohno S: Protein kinase Cδ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem 271:23512, 1996
15. Hannun YA, Loomis CR, Merrill AH Jr, Bell RM: Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 261:12604, 1986
16. Nakamura T, Abe A, Balazovich KJ, Wu D, Suchard SJ, Boxer LA, Shayman JA: Ceramide regulates oxidant release in adherent neutrophils. J Biol Chem 269:18384, 1994
17. Merrill AH Jr, Hannun YA, Bell RM: Introduction: Sphingolipids and their metabolites in cell regulation. Adv Lipid Res 25:1, 1993
18. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR: A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686, 1995
19. Curnutte JT, Babior BM: Biological defense mechanisms. J Clin Invest 53:1662, 1974
20. Suchard SJ, Hinkovska-Galcheva V, Mansfield PJ, Boxer LA, Shayman JA: Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. Blood 89:2139, 1997
21. Pommier CG, Inada I, Fries LF, Takahashi T, Frank MM, Brown EJ: Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J Exp Med 157:1844, 1983
22. Merrill AH Jr, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R: Structural requirements for long-chain (sphingoid) bases inhibition of protein kinase C in vitro and for cellular effects of these compounds. Biochemistry 28:3138, 1989
23. Sergeant S, McPhail LC: Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils. J Immunol 159:2877, 1997
24. Kjeldsen L, Bjerrum OW, Askaa J, Borregaard N: Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. Biochem J 287: 603, 1992
25. de Chatelet LR, Cooper MR: Modified procedure for the determination of leukocyte alkaline phosphatase. Biochem Med 4:61, 1970
26. Ohta H, Ruan F, Hakomori S, Igarashi Y: Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. Anal Biochem 222:489, 1994
27. Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM: Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras-and sis-transformed normal kidney cells. J Biol Chem 261:8597, 1986
28. syk and paxillin during Fc receptor-mediated phagocytosis in macrophages. J Biol Chem 69:3897, 1994
29. Kent JD, Sergeant S, Burns DJ, McPhail L: Identification and regulation of protein kinase C-δ in human neutrophils. J Immunol 157:4641, 1996
30. Gonzales FA, Seth A, Raden DL, Bowman DS, Fay FS, Davis RJ: Serum-induced translocation of mitogen-activated protein kinase to cell surface ruffling membrane and the nucleus. J Cell Biol 122:1089, 1993
31. Maher RJ, Cao D, Boxer LA, Petty HR: Simultaneous calcium-dependent delivery of neutrophil lactoferrin and reactive oxygen metabolites to erythrocyte targets: Evidence supporting granule-dependent triggering of superoxide deposition. J Cell Physiol 156:226, 1993
32. Hannun YA, Obeid LM, Wolff RA: The novel second messenger ceramide: Identification, mechanism of action, and cellular activity. Adv Lipid Res 25:43, 1993
33. 2 and lactoferrin release in adherent human neutrophils. J Biol Chem 269:8063, 1994
34. Della Bianca V, Grzeskowiak M, Dusi S, Rossi F: Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by FcγRs in human neutrophils. J Leukoc Biol 53:427, 1993
35. Mullmann TJ, Siegel MI, Egan RW, Billah MM: Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism. J Biol Chem 266:2013, 1991
36. Dougherty RW, Dubay GR, Niedel JE: Dynamics of the diradylglycerol responses of stimulated phagocytes. J Biol Chem 264:11263, 1989.
37. Billah MM, Eckel S, Mullmann TJ, Egan RW, Siegel MI: Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils: Involvement of phospatidate phosphohydrolase in signal transduction. J Biol Chem 264:17069, 1989
38. Tyagi SR, Burnham DN, Lambeth JD: On the biological occurrence and regulation of 1-acyl and 1-O-alkyl-diradylglycerols in human neutrophils: Selective destruction of diacyl species using Rhizopus lipase. J Biol Chem 264:12977, 1989
39. Wilson E, Wang E, Mullins RE, Uhlinger DJ, Liotta DC, Lambeth JD, Merrill AH Jr: Modulation of free sphingosine levels in human neutrophils by phorbol esters and other factors. J Biol Chem 263:9304, 1988