Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S1 pocket using conformationally constrained inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3074-3082

  Hanessian, S ^a   MacKay, D B ^a   Moitessier, N ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; CGS 27023A; CIPEMASTAT; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PROLINE;

ARTICLE; BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

COLLAGENASES; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; PROLINE; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035855834     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010096n     Document Type: Article

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