Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides

Journal of Medicinal Chemistry

Volumn 40, Issue 6, 1997, Pages 1026-1040

  Esser, Craig K ^a   Bugianesi, Robert L ^a   Caldwell, Charles G ^a   Chapman, Kevin T ^a   Durette, Philippe L ^a   Girotra, Narindar N ^a   Kopka, Ihor E ^a   Lanza, Thomas J ^a   Levorse, Dorothy A ^a   MacCoss, Malcolm ^a   Owens, Karen A ^a   Ponpipom, Mitree M ^a   Simeone, Joseph P ^a   Harrison, Richard K ^a   Niedzwiecki, Lisa ^a   Becker, Joseph W ^a   Marcy, Alice I ^a   Axel, Melinda G ^a   Christen, Amy J ^a   McDonnell, Joseph ^a   Moore, Vernon L ^a   Olszewski, Julie M ^a   Saphos, Cheryl ^a   Visco, Denise M ^a   Shen, Frank ^a   Colletti, Adria ^a   Krieter, Philip A ^a   Hagmann, William K ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; GELATINASE A; L 758354; METALLOPROTEINASE INHIBITOR; RECOMBINANT INTERLEUKIN 1BETA; STROMELYSIN; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLEURA CAVITY; RABBIT; RAT; X RAY CRYSTALLOGRAPHY;

EID: 15144353166     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960465t     Document Type: Article

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102. Female C57B1/6 mice, 6-8 weeks of age, were purchased from Jackson Laboratories. All procedures with animals were approved by Merck Research Laboratories IACUC Committee.