Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors

Journal of Medicinal Chemistry

Volumn 42, Issue 10, 1999, Pages 1723-1738

  Kiyama, Ryuichi ^a   Tamura, Yoshinori ^a   Watanabe, Fumihiko ^a   Tsuzuki, Hiroshige ^a   Ohtani, Mitsuaki ^a   Yodo, Mitsuaki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GELATINASE; GELATINASE A; GELATINASE B; STROMELYSIN; SULFONAMIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROGEN BOND; MOLECULAR MODEL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SIMULATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; GELATINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0033587024     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980514x     Document Type: Article

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