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Volumn 8, Issue 11, 1998, Pages 1397-1402

New synthetic inhibitors of microtubule depolymerization

Author keywords

[No Author keywords available]

Indexed keywords

BORNEOL; PACLITAXEL; PACLITAXEL DERIVATIVE;

EID: 0032474486     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00226-1     Document Type: Article
Times cited : (43)

References (27)
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    • note
    • 3. In 1992 PT was approved by the FDA for the treatment of drug refractory metastatic ovarian cancer.
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    • 6. Three new classes of natural products with microtubule stabilizing properties have been described in the meantime: (a) the macrolides epothilone A and B: Kowalski, R. J.; Giannakakon, P.; Hamel, E. J. Biological Chem. 1997, 272, 2534; Bollag, D. M.; McQueney, P. A.; Zhu, J.; Hensens, O.; Konpal, L.; Liesch, M. Goetz, E. Lazarides, C.M. Woods Cancer Res. 1995, 55, 2325-2333;
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    • 7. Wender, P. A.; Mucciaro, T. P. J. Am. Chem. Soc. 1992, 114, 5878; for further studies in the pinene series see: Wender, P. A.; Glass, T. E. Synlett 1995, 516; Wender, P. A.; Floreancig, P. E.; Glass, T. E.; Natchus, M. G.; Shuker, A. J.; Sutton, J. C. Tetrahedron Lett. 1995, 36, 4939; Wender, P. A.; Glass, T. E.; Krauss, N. E.; Mühlebach, M.; Peschke, B.; Rawlins, D. B. J. Org. Chem. 1996, 61, 7662.
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    • note
    • 2-
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    • note
    • 9. The syntheses of the discussed compounds is described in detail in DE 4416374 and DE 19513040.
  • 22
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    • note
    • 10. Calculations utilized the MM3-force field implemented in Alchemy 2000®.
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    • 13. Data were take from internet http://epnws1.ncicrf.gov:2345/dis3d/drugs/figures/125973gifg.html.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.