D-ring substituted rhazinilam analogues: Semisynthesis and evaluation of antitubulin activity

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2961-2969

  Dupont, Christophe ^a   Guénard, Daniel ^a   Tchertanov, Luba ^a   Thoret, Sylviane ^a   Guéritte, Françoise ^a  

^a CNRS   (France)

Author keywords

Cytotoxicity; Natural products; Rhazinilam; Structure activity relationships; Tubulin

Indexed keywords

1,2 DIDEHYDROASPIDOSPERMIDINE; RHAZINILAM DERIVATIVE; TABERSONINE; TUBULIN; UNCLASSIFIED DRUG; VINCADIFFORMINE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN KB; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; PROTON NUCLEAR MAGNETIC RESONANCE; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; CRYSTALLOGRAPHY, X-RAY; INDOLIZINES; LACTAMS; MAGNETIC RESONANCE SPECTROSCOPY; MICROTUBULES; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 0343485102     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00241-2     Document Type: Article

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