Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling

Journal of Cell Biology

Volumn 152, Issue 1, 2001, Pages 1-13

  Ben Yaacov, Sari ^a   Le Borgne, Roland ^b   Abramson, Irit ^a   Schweisguth, Francois ^b   Schejter, Eyal D ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b CNRS   (France)

Author keywords

Cytoskeleton; Drosophila; Peripheral nervous system; Signal transduction; Wiskott Aldrich syndrome

Indexed keywords

ARTICLE; CELL FATE; CELL LINEAGE; DISEASE ASSOCIATION; DROSOPHILA; EMBRYO DEVELOPMENT; GENE SEQUENCE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; WISKOTT ALDRICH SYNDROME;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CATTLE; CELL LINEAGE; DROSOPHILA; DROSOPHILA PROTEINS; EPISTASIS, GENETIC; FEMALE; GENES, INSECT; JUVENILE HORMONES; MALE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PERIPHERAL NERVOUS SYSTEM; PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN; ZYGOTE;

ANIMALIA; HEXAPODA; VESPIDAE;

EID: 0035825181     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.1.1     Document Type: Article

References (101)

1. The genome sequence of Drosophila melanogaster
2. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
3. Notch signaling: Cell fate control and signal integration in development
4. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
5. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development
6. Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases
7. Frizzled regulates the localisation of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
8. The Drosophila couch potato protein is expressed in nuclei of peripheral neuronal precursors and shows homology to RNA-binding proteins
9. The development of normal and ectopic sensilla in the wings of hairy and Hairy wing mutants of Drosophila
10. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila
11. Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila
12. Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages
13. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
14. Notch signalling in Drosophila: Three ways to use a pathway
15. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts
16. Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
17. Wingless signaling in the Drosophila eye and embryonic epidermis
18. The emergence of order in the Drosophila pupal retina
19. Patterning of the Drosophila nervous system: The achaete-scute gene complex
20. Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
21. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
22. Control of actin assembly and disassembly at filament ends
23. Notch signaling in T cell development
24. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
25. WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia
26. Control of neuronal fate by the Drosophila segmentation gene even-skipped
27. The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
28. Characterization and localization of the even-skipped protein of Drosophila
29. Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling
30. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
31. Shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog
32. Analysis of Kruppel protein distribution during early Drosophila development reveals posttranscriptional regulation
33. Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
34. Subcellular localization of suppressor of hairless in Drosophila sense organ cells during Notch signalling
35. Revisiting the Drosophila microchaete lineage: A novel intrinsically asymmetric cell division generates a glial cell
36. Genesis of the Drosophila peripheral nervous system
37. A genetic programme for neuronal connectivity
38. Sensory neurones and peripheral pathways in Drosophila embryos
39. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
40. Studying Drosophila embryogenesis with P-lacZ enhancer trap lines
41. Development of adult sensilla on the wing and notum of Drosophila melanogaster
42. A dual function of the Notch gene in Drosophila sensillum development
43. The emergence of sense organs in the wing disc of Drosophila
44. Wiskott-Aldrich syndrome: A gene, a multifunctional protein and the beginnings of an explanation
45. Asymmetric segregation of Numb and prospero during cell division
46. The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
47. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42
48. Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton
49. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors
50. Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division
51. Control of cell divisions in the nervous system: Symmetry and assymetry
52. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
53. Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
54. The isolation of structural genes from libraries of eucaryotic DNA
55. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
56. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
57. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures
58. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
59. Analysis of Drosophila photo-receptor axon guidance in eye-specific mosaics
60. The Wiskott-Aldrich syndrome
61. The Wiskott-Aldrich syndrome: Studies of lymphocytes, granulocytes, and platelets
62. Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
63. Delta function is required for bristle organ determination and morphogenesis in Drosophila
64. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
65. The role of segment polarity genes during Drosophila neurogenesis
66. Vectors for P-element transformation in Drosophila
67. Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development
68. Molecular links between endocytosis and the actin cytoskeleton
69. A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum
70. Defects in Wiskott-Aldrich syndrome blood cells
71. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
72. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development
73. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
74. The primary immunodeficiencies
75. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
76. The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation
77. Segregation of myogenic lineages in Drosophila requires numb
78. The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila
79. Requirement for dynamin during Notch signaling in Drosophila neurogenesis
80. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells
81. Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila
82. Notch signalling in development: On equivalence groups and asymmetric developmental potential
83. Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
84. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
85. Numb antagonizes Notch signaling to specify sibling neuron cell fates
86. P element-mediated transformation
87. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
88. Progress in protrusion: The tell-tale scar
89. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
90. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
91. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
92. From grasshopper to Drosophila: A common plan for neuronal development
93. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
94. Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
95. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
96. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
97. Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage
98. Neuronal development in the Drosophila retina: Monoclonal antibodies as molecular probes