2-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2λ6-benzo [1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2001, Pages 1847-1852

  Apfel, C ^a   Banner, D W ^a   Bur, D ^a,b   Dietz, M ^a   Hubschwerlen, C ^a,c   Locher, H ^a,c   Marlin, F ^a   Masciadri, R ^a   Pirson, W ^a   Stalder, H ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c Morphochem AG Basel   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

(5 CHLORO 2 OXO 1,4 DIHYDRO 2H QUINAZOLIN 3 YL)ACETIC ACID HYDRAZIDE; ACETAMIDE DERIVATIVE; ANTIBIOTIC AGENT; HYDROXAMIC ACID DERIVATIVE; PEPTIDE DEFORMYLASE INHIBITOR; QUINAZOLINE DERIVATIVE; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN;

AMIDOHYDROLASES; AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; BACTERIA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; HYDROXAMIC ACIDS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; QUINAZOLINES; THIADIAZINES;

EID: 0035821593     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000352g     Document Type: Article

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