Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP)

Toxicology

Volumn 160, Issue 1-3, 2001, Pages 219-226

  Willhite, C C ^a  

^a Dept of Toxic Substances Control ^*  (United States)

Author keywords

DEHP; Peroxisome proliferation; Phthalates; Risk assessment

Indexed keywords

HYDROGEN PEROXIDE; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; FATTY ACID OXIDATION; FEMALE; HEPATOMEGALY; HUMAN; HYPERPLASIA; LIVER CARCINOMA; MALE; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RISK ASSESSMENT; SPECIES DIFFERENCE; TISSUE LEVEL;

ANIMALS; CARCINOGENS; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; PEROXISOME PROLIFERATORS; PEROXISOMES; PUBLIC POLICY; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RISK ASSESSMENT; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA; RODENTIA;

EID: 0035819853     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00451-0     Document Type: Article

References (67)

1. Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis
2. Oral toxicity of bis(2-ethylhexyl)phthalate during pregnancy and suckling in the Long-Evans rat
3. Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients
4. The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens
5. Chronic oral toxicity of di(2-ethylhexyl)phthalate for rats, guinea pigs and dogs
6. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?
7. Central role of PPAR alpha in the mechanism of hepatocarcinogenic peroxisome proliferators
8. Chronic toxicity of di(2-ethylhexyl)phthalate in rats
9. A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new U.S. EPA risk assessment guidelines
10. Control of β-oxidation pathway by a novel family of nuclear hormone receptors
11. Positive regulation of the peroxisomal β-oxidation pathway by fatty acids through activation of peroxisomal proliferator-activated receptors (PPARs)
12. Peroxisome proliferation due to di(2-ethylhexyl)phthalate (DEHP): Species differences and possible mechanisms
13. The steroid and thyroid hormone receptor superfamily
14. National Institute of Occupational Health (NIOH) Sweden and National Institute for Occupational Safety and Health (NIOSH) basis for an occupational health standard: Di(2-ethylhexyl)phthalate (DEHP)
15. Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator receptor alpha
16. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
17. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP or DOTP alters sexual differentiation in the male rat
18. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative gene expression
19. Peroxisome proliferator-activated receptor alpha: Role in rodent liver cancer and species differences
20. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
21. The carcinogenicity of dietary di(2-ethylhexyl)phthalate (DEHP) in Fischer 344 and B6C3F1 mice
22. Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter
23. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
24. Biochemical mechanisms of induction of hepatic microsomal peroxisomal proliferation
25. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators
26. Effects of n-3 fatty acids on lipid metabolism
27. Comment on the carcinogenic potential of di(2-ethylhexyl)phthalate
28. Chemical carcinogens: A review of the science and its associated principles, March 14
29. Peroxisome proliferator activated receptor-α expression in human liver
30. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone sythesis during sexual differentiation in the male rat
31. Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
32. Reduction of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia
33. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl)phthalate in the rat
34. In vivo studies on the mechanism of di(2-ethylhexyl)phthalate carcinogenesis
35. Peroxisome proliferation and hepatocarcinogenesis
36. Hypolipidemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
37. Non-genotoxic hepatocarcinogenesis: Suppression of apoptosis by peroxisome proliferators
38. Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology
39. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARalpha)
40. Use of suppression-PCR subtractive hybridisation to identify genes that demonstrate altered expression in male rat and guinea pig livers following exposure to Wy-14,643, a peroxisome proliferator and non-genotoxic hepatocarcinogen
41. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
42. cCDNA cloning, chromosomal mapping and functional characterization of the human peroxisomal proliferator activated response
43. Teratogenicity/fetotoxicity of DEHP in mice
44. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
45. Peroxisome proliferator-activated receptors: Structures and function
46. Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice
47. Report of a EPA peer review workshop on alpha-2μ-globulin: Association with renal toxicity and neoplasia in the male rat
48. Alpha-2μ-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat
49. Di(2-ethylhexyl)phthalate (DEHP)
50. Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis
51. Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene
52. Receptor and nonreceptor mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor α-null mice
53. 3H] thymidine and Salmonella mutagenesis assays
54. Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogenesis
55. The peroxisome proliferator (PP) response element (PPRE) upstream of the human acyl CoA oxidase gene is inactive in a sample human population: Significance for species differences in response to PPs