Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost

Vaccine

Volumn 19, Issue 20-22, 2001, Pages 2803-2811

  Billaut Mulot, Odile ^a   Idziorek, Thierry ^a   Loyens, Marc ^a   Capron, André ^a   Bahr, George M ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

DNA vaccination; HIV; IL 18

Indexed keywords

ANTIBODY; ANTIGEN; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 4; M PROTEIN; PLASMID DNA; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANTIBODY TITER; ARTICLE; CELL CULTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SPLEEN CELL; T LYMPHOCYTE; TREATMENT OUTCOME;

AIDS VACCINES; ANIMALS; CYTOKINES; EPITOPES; FEMALE; GENE PRODUCTS, GAG; GENE PRODUCTS, NEF; GENE PRODUCTS, TAT; HIV ANTIBODIES; HIV-1; IMMUNIZATION; IMMUNIZATION, SECONDARY; INTERLEUKIN-18; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA;

EID: 0035815546     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00004-4     Document Type: Article

References (32)

1. DNA vaccines: Immunology, application, and optimization
2. Modulating the immune response to genetic immunization
3. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
4. Protection from pathogenic SIV challenge using multigenic DNA vaccines
5. Vaccination of seronegative volunteers with human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of β-chemokines
6. Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment
7. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: Safety and host response
8. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
9. An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV
10. Studies of the neutralizing activity and avidity of anti-human immunodeficiency virus type 1 Env antibody eliced by DNA priming and protein boosting
11. Vaccination with HIV-1 gp120 protein subunit
12. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
13. Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination
14. Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine
15. Structure and expression of Tat, Rev and Nef specific transcripts of human immunodeficiency type 1 in infected lymphocytes and macrophages
16. HIV accessory proteins: Leading roles for the supporting cast
17. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
18. Coimmunization with IFN-gamma or IL-2, but not IL-13 or IL-4 cDNA can enhance Th1-type DNA vaccine-induced immune responses in vivo
19. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine
20. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines
21. Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvants
22. In vivo immunomodulation following intradermal injection with DNA encoding IL-18
23. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
24. Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses
25. Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid
26. Nucleic acid vaccination with HIV regulatory genes: A combination of HIV-1 genes in separate plasmids induces strong immune responses
27. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes
28. Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA
29. In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen
30. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of TH1 but not TH2 cells and exerts its effect independently of IL-12
31. The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1 specific DNA vaccine
32. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration