Antiviral CD8+ T cell responses in neonatal mice: Susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells

Journal of Experimental Medicine

Volumn 193, Issue 5, 2001, Pages 595-605

  Moser, Janice M ^a   Altman, John D ^a,b   Lukacher, Aron E ^a  

^a Department of Pathology ^*  (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD8+ T lymphocytes; Intracellular IFN ; Neonatal mice; Polyoma virus; Tetramers

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; GLYCAN; PERFORIN; T LYMPHOCYTE RECEPTOR; VIRUS MIDDLE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CANCER SUSCEPTIBILITY; CELL LEVEL; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXIC T LYMPHOCYTE; MOUSE; NEWBORN; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, POLYOMAVIRUS TRANSFORMING; ANTIGENS, VIRAL, TUMOR; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOTOXICITY TESTS, IMMUNOLOGIC; DISEASE SUSCEPTIBILITY; EPITOPES; IMMUNITY, CELLULAR; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; MICE; MICE, INBRED C3H; MICE, INBRED CBA; NEOPLASMS, EXPERIMENTAL; PAPILLOMAVIRUS INFECTIONS; PEPTIDE FRAGMENTS; POLYOMAVIRUS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TUMOR VIRUS INFECTIONS;

EID: 0035809308     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.5.595     Document Type: Article

References (40)

1. H2 immunity in neonatal mice
2. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells
3. Induction of protective CTL responses in newborn mice by a murine retrovirus
4. Induction of neonatal TH1 and CTL responses by live viral vaccines: A role for replication patterns within antigen presenting cells?
5. Induction of cytotoxic T cell responses in newborn mice by DNA immunization
6. Immune response to neonatal genetic immunization
7. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization
8. DNA vaccines for influenza virus: Differential effects of maternal antibody on immune responses to hemagglutinin and nucleoprotein
9. Polyoma tumorigenesis in mice: Evidence for dominant resistance and dominant susceptibility genes of the host
10. Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen
11. The role of the thymus in transplantation resistance induced by polyoma virus
12. Immunologic responsiveness and the induction of experimental neoplasms
13. k-restricted epitope in the middle T protein
14. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
15. Tumor immunology: The glass is half full
16. + T cells in patients with advanced melanoma
17. + T cells in vivo during infection and tumor rejection
18. Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells
19. An intracisternal A-particle sequence codes for an antigen recognized by syngeneic cytolytic T lymphocytes on a mouse spontaneous leukemia
20. Cross-recognition of two middle T protein epitopes by immunodominant polyoma virus-specific CTL
21. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
22. Structure of peptides associated with MHC class I molecules
23. Cloned cytotoxic T lymphocytes recognize cells expressing discrete fragments of the SV40 tumor antigen
24. T cell affinity maturation by selective expansion during infection
25. A kinetic basis for T cell receptor repertoire selection during an immune response
26. Activation of low avidity. CTL specific for a self epitope results in tumor rejection but not autoimmunity
27. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans
28. + T lymphocytes
29. Post-thymic T lymphocyte maturation during ontogenesis
30. + T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigen
31. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors
32. Immunological elimination of infected cells as the candidate mechanism for tumor protection in polyomavirus mice
33. Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts
34. Separation of host range from transformation functions of the hr-t gene of polyomavirus
35. Polyoma virus middle T is essential for virus replication and persistence as well as for tumor induction in mice
36. Sequential development of structural and functional alterations in T cells from tumor-bearing mice
37. Human immunodeficiency virus-specific CD8 T lymphocytes have down-modulated CD3ζ and CD28, key signaling molecules for T-cell activation
38. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
39. + T cells produce antiviral cytokines but are impaired in cytolytic function
40. Viral immune evasion due to persistence of activated T cells without effector function