Induction of neonatal TH1 and CTL responses by live viral vaccines: A role for replication patterns within antigen presenting cells?

Vaccine

Volumn 16, Issue 14-15, 1998, Pages 1473-1478

  Siegrist, Claire Anne ^a   Saddallah, Fatiha ^a   Tougne, Chantal ^a   Martinez, Xavier ^a   Kovarik, Jiri ^a   Lambert, Paul Henri ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Immunization; Live vaccines; Newborns; TH1 TH2

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2A; INTERLEUKIN 5; LIVE VACCINE; MEASLES VACCINE;

ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGENICITY; CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HELPER CELL; IMMUNE RESPONSE; IMMUNIZATION; MEASLES VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENDAI VIRUS; T LYMPHOCYTE; VIRUS REPLICATION;

ANIMALS; ANIMALS, NEWBORN; ANTIGEN-PRESENTING CELLS; LYMPHOCYTE ACTIVATION; MEASLES VACCINE; MEASLES VIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTATION; RESPIROVIRUS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS; VACCINES, ATTENUATED; VIRAL VACCINES; VIRUS REPLICATION;

EID: 0032147017     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00111-X     Document Type: Conference Paper

References (9)

1. 1 Sarzotti, M., Bobbins, D.S. and Hoffman, P.M. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 1996, 271, 1726-1728
2. 2 Ridge, J.P., Fuchs, E.J. and Matzinger, P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996, 271, 1723-1726
3. 3 Barrios, C., Brawand, P., Berney, M., Brandt, C., Lambert, P.H. and Siegrist, C.A. Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a TH2-biased pattern which persists after adult boosting. Eur. J. Immunol. 1996, 26, 1489-1496
4. 4 Martinez, X., Brandt, C. and Saddallah, F. et al. DNA immunization circumvents deficient induction of TH1 and CTL responses in neonates and during early life. Proc. Natl Acad. Sci. USA 1997, 94, 8726-8731
5. 5 Maru, M., Haraguchi, M., Sato, K., Hotta, H. and Homma, M. Evaluation of a protease activation mutant of Sendai virus as a potent live vaccine. Vet. Microbiol. 1992, 30, 1-12
6. 6 Klinman, D.M., Yi, A.K., Beaucage, S.L., Conover, J. and Krieg, A.M. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon gamma. Proc. Natl Acad. Sci. USA 1996, 93, 2879-2883
7. 7 Sato, Y., Roman, M. and Tighe, H. et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996, 273, 352-354
8. 8 Ballas, Z.K., Rasmussen, W.L. and Krieg, A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 1996, 157, 1840-1845
9. 9 Barrios, C., Brandt, C., Berney, M., Lambert, P.H. and Siegrist, C.A. Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects. Eur. J. Immunol. 1996, 26, 2666-2670