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Volumn 44, Issue 16, 2001, Pages 2499-2502

Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases

(14) Pikul, S a Ohler, N E c Ciszewski, G c Laufersweiler, M C c Almstead, N G b De, B c Natchus, M G c Hsieh, L C c Janusz, M J c Peng, S X c Branch, T M c King, S L c Taiwo, Y O c Mieling, G E c

a Avalon Pharmaceuticals (United States)

b PTC THERAPEUTICS (United States)

c PROCTER AND GAMBLE PHARMACEUTICALS (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PIPERIDINE DERIVATIVE; STROMELYSIN;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; PH; RACEMIC MIXTURE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BIPHENYL COMPOUNDS; BLOOD PROTEINS; CARBOXYLIC ACIDS; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035797369 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm015531s Document Type: Article

Times cited : (58)

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