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Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 15, 2001, Pages 1975-1979

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

(15) Tullis, Joshua S a Laufersweiler, Matthew J a VanRens, John C a Natchus, Michael G a Bookland, Roger G a Almstead, Neil G a Pikul, Stanislaw a De, Biswanath a Hsieh, Lily C a Janusz, Michael J a Branch, Todd M a Peng, Sean X a Jin, Yingkun Y a Hudlicky, Tomas b Oppong, Kofi b

a PROCTER AND GAMBLE PHARMACEUTICALS (United States)

b University of Florida (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; COLLAGENASE 3; CYCLOHEXYLGLYCINE DERIVATIVE; GELATINASE A; GLYCINE DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE INHIBITOR; NANOPARTICLE; STROMELYSIN; TANOMASTAT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DERIVATIZATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOXYLIC ACIDS; COLLAGENASES; ENZYME INHIBITORS; GLYCINE; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; METALLOENDOPEPTIDASES; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035817393 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)00371-7 Document Type: Article

Times cited : (27)

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