Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines

Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2001, Pages 1060-1071

  Natchus, M G ^a   Bookland, R G ^a   Laufersweiler, M J ^a   Pikul, S ^a   Almstead, N G ^a   De, B ^a   Janusz, M J ^a   Hsieh, L C ^a   Gu, F ^a   Pokross, M E ^a   Patel, V S ^a   Garver, S M ^a   Peng, S X ^a   Branch, T M ^a   King, S L ^a   Baker, T R ^a   Foltz, D J ^a   Mieling, G E ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; COLLAGENASE 3; GELATINASE A; INTERSTITIAL COLLAGENASE; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PROPARGYLGLYCINE; STROMELYSIN; TANOMASTAT;

ARTICLE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50;

ALKYNES; CARBOXYLIC ACIDS; GLYCINE; HUMANS; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035966867     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000477l     Document Type: Article

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