Heterocycle-based MMP inhibitors with P2′ substituents

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 8, 2001, Pages 1009-1013

  Pikul, Stanislaw ^a   Dunham, Kelly McDow ^a,b   Almstead, Neil G ^a   De, Biswanath ^a   Natchus, Michael G ^a   Taiwo, Yetunde O ^a   Williams, Lisa E ^a   Hynd, Barbara A ^a   Hsieh, Lily C ^a   Janusz, Michael J ^a   Gu, Fei ^a   Mieling, Glen E ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b Avalon Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; COLLAGENASE 3; GELATINASE A; GELATINASE B; HETEROCYCLIC COMPOUND; HYDROXAMIC ACID; MATRILYSIN; MATRIX METALLOPROTEINASE INHIBITOR; STROMELYSIN; SULFONAMIDE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITOR COMPLEX; STRUCTURE ANALYSIS; X RAY ANALYSIS;

COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 1-RING; INHIBITORY CONCENTRATION 50; MACROMOLECULAR SUBSTANCES; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035938405     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00137-8     Document Type: Article

References (18)