Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases

Journal of Medicinal Chemistry

Volumn 42, Issue 1, 1999, Pages 87-94

  Pikul, Stanislaw ^a   McDow Dunham, Kelly L ^a   Almstead, Neil G ^a   De, Biswanath ^a   Natchus, Michael G ^a   Anastasio, Melanie V ^b   McPhail, Sara J ^b   Snider, Catherine E ^b   Taiwo, Yetunde O ^a   Chen, Longyin ^a,c   Dunaway, C Michelle ^b   Gu, Fei ^a   Mieling, Glen E ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CGS 27023A; COLLAGENASE; DEXTRO AMINO ACID; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; N HYDROXY 2 [[METHYLPHENYLPHOSPHINYL]BENZYLAMINO] 4 METHYLPENTANAMIDE; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033552866     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980142s     Document Type: Article

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