PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3414-3426

  Davidson, Dominique ^a,b   Veillette, André ^a,b,c,d  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Department of Medicine ^*  (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Inhibition; Lymphocyte; Phosphatase; PTP PEST; Shc

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; FOCAL ADHESION KINASE 2; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PAXILLIN; PROTEIN CSK; PROTEIN FAK; PROTEIN PTP PEST; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME SUBSTRATE; HEMATOPOIETIC CELL; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; B-LYMPHOCYTES; CELLS, CULTURED; CYTOSKELETAL PROTEINS; HOMEOSTASIS; KINETICS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PAXILLIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RAS PROTEINS; RECOMBINANT PROTEINS; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; TRANSFECTION;

EID: 0035796465     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3414     Document Type: Article

References (59)

1. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration and cytokinesis in fibroblasts
2. B cell development: Signal transduction by antigen receptors and their surrogates
3. SHIP modulates immune receptor responses by regulating membrane association of Bk
4. Signal transduction from the B cell antigen-receptor
5. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells
6. The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds
7. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction
8. Structure of the murine MPTP-PEST gene: Genomic organization and chromosomal mapping
9. Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity
10. The Src and Csk families of tyrosine protein kinases in hemopoietic cells
11. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk
12. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
13. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells
14. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
15. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST
16. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in lymphocytes and determines thresholds for negative selection
17. Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn
18. Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells
19. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST
20. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
21. Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5′-phosphatase
22. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP
23. Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase
24. Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
25. The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes
26. 2+ mobilization by Src homology 2 domain-containing inositol 5′-phosphatase (SHIP)
27. Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase
28. Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig
29. Transactivation by AP-1 is a molecular target of T cell clonal anergy
30. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
31. Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP
32. Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase
33. Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
34. Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes
35. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling
36. Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain
37. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
38. 2+ oscillatory response
39. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
40. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
41. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
42. Tyrosine protein kinases in T lymphocytes
43. Regulated commitment of TNF receptor signaling: A molecular switch for death or activation
44. Activation-induced bi-dentate interaction of SHIP and Shc in B lymphocytes
45. T cell antigen receptor signal transduction
46. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
47. Csk controls antigen receptor-mediated development and selection of T-lineage cells
48. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin
49. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK cell migration
50. p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction
51. The RasGAP-binding protein p62dok is a mediator of inhibitory FcγRIIB signals in B cells
52. Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions
53. The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes
54. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p561ck
55. Signal transduction by lymphocyte antigen receptors
56. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase
57. Tec kinases: A family with multiple roles in immunity
58. Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection
59. Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction