Orexins/hypocretins: Waking up the scientific world

Clinical Endocrinology

Volumn 54, Issue 4, 2001, Pages 421-429

  Taheri, Shahrad ^a   Bloom, Stephen ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; CATECHOLAMINE; CHOLECYSTOKININ; COCAINE; CORTICOTROPIN RELEASING FACTOR; EXCITATORY AMINO ACID; GALANIN; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; GROWTH HORMONE RELEASING FACTOR; INTERMEDIN; NEUROPEPTIDE; NEUROPEPTIDE Y; OPIATE PEPTIDE; OREXIN A; OREXIN B; OXYNTOMODULIN; PROLACTIN RELEASING FACTOR; SECRETIN;

AMIDATION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APPETITE; BRAIN REGION; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CATECHOLAMINE RELEASE; CIRCADIAN RHYTHM; FOOD INTAKE; HUMAN; IMMUNOREACTIVITY; LATERAL HYPOTHALAMUS; MONOAMINERGIC SYSTEM; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SECRETORY VESICLE; SEQUENCE HOMOLOGY; SLEEP; STOMACH ACID SECRETION; SYNAPSE VESICLE;

AMINO ACID SEQUENCE; ANIMALS; APPETITE REGULATION; BASE SEQUENCE; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 17; HEMODYNAMIC PROCESSES; HUMANS; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PITUITARY GLAND; PITUITARY HORMONES; PROTEIN PRECURSORS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SLEEP;

EID: 0035725289     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2001.01247.x     Document Type: Review

References (56)

1. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
2. Down-regulation of orexin gene expression by severe obesity in the rats: Studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone
3. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
4. Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord
5. Distribution of orexin/hypocretin in the rat median eminence and pituitary
6. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
7. Hypothalamic hypocretin orexin: Robust innervation of the spinal cord
8. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
9. The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
10. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
11. Orexin A activates locus coeruleus cell firing and increases arousal in the rat
12. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurons of the lateral hypothalamus
13. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
14. Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients
15. Synaptic interaction between hypocretin orexin and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
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17. Possible involvement of orexin in the stress reaction in rats
18. Transgenic approach to the study of body weight regulation
19. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
20. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion
21. Orexin synthesis and response in the gut
22. Orexins/hypocretins regulate drinking behaviour
23. Centrally administered orexin/hypocretin activates HPA axis in rats
24. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
25. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin orexin receptor 2 gene
26. Orexin receptors are expressed in the adrenal medulla of the rat
27. Independent feeding and metabolic actions of orexins in mice
28. The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C
29. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
30. Control of food intake via leptin receptors in the hypothalamus
31. Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models
32. Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites
33. Distribution of orexin neurons in the adult rat brain
34. Hypocretin orexin deficiency in human narcolepsy
35. Acute orexin effects on insulin secretion in the rat: In vivo and in vitro studies
36. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
37. Neurons containing hypocretin orexin project to multiple neuronal systems
38. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats
39. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner
40. Preprohypocretin orexin and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area
41. Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin
42. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
43. Structure and function of human prepro-orexin gene
44. Cardiovascular regulatory actions of the hypocretins in brain
45. Sympathetic and cardiovascular actions of orexins in conscious rats
46. The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors
47. Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
48. Quantification of orexin A immunoreactivity and prepro-orexin mRNA in the CNS of Zucker rats
49. Distribution and quantification of immunoreactive orexin A in rat tissues
50. Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system
51. Role of orexins in sleep and arousal mechanisms
52. Distribution of orexin receptor mRNA in the rat brain
53. To eat or sleep? The role of orexin in coordination of feeding and wakefulness
54. Down regulation of the prepro-orexin gene expression in genetically obese mice
55. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice
56. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight