Proopiomelanocortin and the immune-neuroendocrine connection

Annals of the New York Academy of Sciences

Volumn 885, Issue , 1999, Pages 161-172

  Blalock, J Edwin ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; BETA ENDORPHIN; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MESSENGER RNA; OPIATE RECEPTOR; PROOPIOMELANOCORTIN;

ANTINOCICEPTION; CONFERENCE PAPER; CORTICOTROPIN DEFICIENCY; HEMATOPOIESIS; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOCYTE; MACROPHAGE; NEUROENDOCRINE SYSTEM; NEUROMODULATION; NONHUMAN;

EID: 0032787654     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb08673.x     Document Type: Conference Paper

References (68)

1. 1. Blalock, J.E. & E.M. Smith. 1980. Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins. Proc. Natl. Acad. Sci. USA 77: 5972-5974.
2. 2. Smith, E.M. & J.E. Blalock. 1981. Human lymphocyte production of corticotropin and enclorphin-like substances: association with leukocyte interferon. Proc. Natl. Acad. Sci. USA 78: 7530-7534.
3. 3. Blalock, J.E. 1984. Relationships between neuroendocrine hormones and lymphokines. In Lymphokines. E. Pick, Ed: 1-13. Academic Press, Orlando.
4. 4. Epstein, L.B., M.E. Rose, N.H. McManus & C.H. Li.. 1982. Absence of functional and structural homology of natural and recombinant human leukocyte interferon (IFN-alpha) with human alpha-ACTH and beta-endorphin. Biochem. Biophys. Res. Commun. 104: 341-346.
5. 5. Bloom, F.E. 1987. Molecular markers of neuronal specificity. In Molecular Neuroscience: Expression of Neural Genes. F. Wong, D.C. Eaton, D.A. Konkel & J.R. Perez-Pola, Eds.: 1-10. Alan R. Liss. New York.
6. 6. Blalock, J.E. & E.M. Smith. 1985. A complete regulatory loop between the immune and neuroendocrine systems. Fed. Proc. 44: 108-111.
7. 7. Smith, E.M., W.J. Meyer, & J.E. Blalock. 1982. Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis. Science 218: 1311-1312.
8. 8. Endo, Y., T. Sakata & S. Watanabe. 1985. Identification of proopiomelanocortin-producing cells in the rat pyloric antrum and duodenum by in situ mRNA-cDNA hybridization. Biomed. Res. 6: 253-256.
9. 9. Westly, H.J., A.J. Kleiss, K.W. Kelley, P.K.Y. Wong & P.H. Yuen. 1986. Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene. J. Exp. Med. 163: 1589-1594.
10. 10. Lolait, S.J., J.A. Clements, A.J. Markwick, C. Cheng, M. McNally, A.I. Smith & J.W. Funder. 1986. Pro-opiomelanocortin messenger ribonucleic acid and post-translational processing of beta endorphin in spleen macrophages. J. Clin. Invest. 77: 1776-1779.
11. 11. Oates, E.L., G.P. Allaway, G.R. Armstrong, R.A. Boyajian, J.H. Kehr & B.S. Probhakar. 1988. Human lymphocytes produce pro-opiomelanocortin gene-related transcripts. Effects of lymphotropic viruses. J. Biol. Chem. 263: 10041-10044.
12. 12. Buzzetti, R., L. McLoughlin, P.M. Lavender, A.J. Clark & L.H. Rees. 1989. Expression of pro-opiomelanocortin gene and quantification of adrenocorticotropic hormone-like immunoreactivity in human normal peripheral mononuclear cells and lymphoid and myeloid malignancies. J. Clin. Invest. 83: 733-737.
13. 13. Smith, E.M., F.S. Galin, R.D. Leboeuf, D.H. Coppenhaver, D.V. Harbour & J.E. Blalock. 1990. Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide. Proc. Natl. Acad. Sci. USA 87: 1057-1060.
14. 14. Galin, F.S., R.D. Leboeuf & J.E. Blalock. 1990. A lymphocyte mRNA encodes the adrenocorticotropin β-lipotropin region of the pro-opiomelanocortin gene. Prog. Neuro. Endocrin. Immunol. 3: 205-208.
15. 15. Galin, F.S., R.D. Leboeuf & J.E. Blalock. 1991. Corticotropin-releasing factor upregulates expression of two truncated pro-opiomelanocortin transcripts in murine lymphocytes. J. Neuroimmunol. 31: 51-58.
16. 16. Panerai, A.E. & P. Sacerdote. 1997. Beta-endorphin in the immune system: a role at last? Immunol. Today 18: 317-319.
17. 17. Sharp, B. & T. Yaksh. 1997. Pain killers of the immune system. Nature Med. 3: 831-832.
18. 18. Lyons, P.D. & J.E. Blalock. 1997. Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytes. J. Neuroimmunol. 78: 47-56.
19. 19. Wybran, J., T. Appelboom, J.-P. Famaey & A. Govaerts. 1979. Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes. J. Immunol. 123: 1068-1070.
20. 20. McDonough, R.J., J.J. Madden, A. Falek, D.A. Shafer, M. Pline, D. Gordon, P. Bokos, J.C. Kuehnle & J. Mendelson. 1980. Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: In vivo evidence for opiate receptor sites on T lymphocytes. J. Immunol. 125: 2539-2543.
21. 21. Johnson, H.M., E.M. Smith, B.A. Torres & J.E. Blalock. 1982. Neuroendocrine hormone regulation of in vitro antibody formation. Proc. Natl. Acad. Sci. USA 79: 4171-4174.
22. 22. Lopker, A., L.G. Abood, W. Hoss & F.J. Lionetti. 1980. Stereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes. Biochem. Pharm. 29: 1361-1365.
23. 23. Carr, D.J., B.R. Decosta, C.H. Kim, A.E. Jacobson, V. Guarcello, K.C. Rice & J.E. Blalock. 1989. Opioid receptors on cells of the immune system: evidence for delta- and kappa-classes. J. Endocrinol. 122: 161-168.
24. 24. Carr, D.J.J. & J.E. Blalock. 1989. Neuroendocrine characteristics of the immune system. EOS J. Immunol. Immunopharmacol. IX: 195-199.
25. 25. Ovadia, H., P. Nitsan & O. Abramsky. 1989. Characterization of opiate binding sites on membranes of rat lymphocytes. J. Neuroimmunol. 21: 93-102.
26. 26. Carr, D.J., C.H. Kim, B. Decosta, A.E. Jacobson, K.C. Rice & J.E. Blalock. 1988. Evidence for a delta-class opioid receptor on cells of the immune system. Cell Immunol. 116: 44-51.
27. 27. Radulescu, R.T., B.R. Decosta, A.E. Jacobson, K.C. Rice & J.E. Blalock. 1991. Biochemical and functional characterization of a mu-opioid receptor binding site on cells of the immune system. Prog. Neuro. Endocrin. Immunol. 4: 166-179.
28. 28. Carr, D.J., B.R. Decosta, A.E. Jacobson, K.C. Rice & J.E. Blalock. 1991. Enantioselective kappa opioid binding sites on the macrophage cell line, P388dl. Life Sci. 49: 45-51.
29. 29. Kieffer, B.L., K. Befort, C. Gaveriaux-Ruff & C.G. Hirth. 1992. The delta-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Nad. Acad. Sci. USA 89: 12048-12052.
30. 30. Evans, C.J., D. Keith, K. Magendzo, H. Morrison & R.H. Edwards. 1992. Cloning of a delta opioid receptor by functional expression. Science 258: 1952-1955.
31. 31. Yasuda, K., K. Raynor, H. Kong, C.D. Breder, J. Takeda, T. Reisine & G.I. Bell. 1993. Cloning and functional comparison of κ and δ opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA 90: 6736-6740.
32. 32. Thompson, R.C., A. Mansour, H. Akil & S.J. Watson. 1993. Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron 11: 903-913.
33. 33. Wang, J.B., Y. Imai, C.M. Eppler, P. Gregor, C.E. Spivak & G.R. Uhl. 1993. μ opiate receptor: cDNA cloning and expression. Proc. Natl. Acad. Sci. USA 90: 10230-10234.
34. 34. Gaveriaux-Ruff, G., F. Simonin, J. Peluso, K. Defort & B. Kieffer. 1994. Expression of opioid receptors mRNAs in immune cells. Regul. Pept. 54: 103-104.
35. 35. Chuang, L.F., T.K. Chuang, K.F. Killam, Jr., A.J. Chuang, H. Kung, L. Yu & R.Y. Chuang. 1994. Delta opioid receptor gene expression in lymphocytes. Biochem. Biophys. Res. Commun. 202: 1291-1299.
36. 36. Chuang, L.F., T.K. Chuang, K.F. Killamk, Jr., Q. Qiu, X.R. Wang, J. Lin, H. Kung, W. Sheng, C. Chao, L. Yu & R.Y. Chuang. 1995. Expression of kappa opioid receptors in human and monkey lymphocytes. Biochem. Biophys. Res. Commun. 209: 1003-1010.
37. 37. Sedqi, M., S. Roy, S. Ramakrishnan, R. Elde & H.H. Loh. 1995. Complementary DNA cloning of a μ opioid receptor from rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 209: 563-574.
38. 38. Gaveriaux, C., J. Peluso, F. Simonin, J. Laforet & B. Kieffer. 1995. Identification of κ- and δ-opioid receptor transcripts in immune cells. FEBS Lett. 369: 272-276.
39. 39. Chuang, T.K., K.F. Killam, Jr., L.F. Chuang, H. Kung, W.S. Sheng, C.C. Chao, L. Yu & R.Y. Chuang. 1995. Mu opioid receptor gene expression in immune cells. Biochem. Biophys. Res. Commun. 216: 922-930.
40. 40. Belkowski, S.M., J. Zhu, L.-Y. Liu-Chen, T.K. Eisenstein, M.W. Aidler & T.J. Rogers. 1995. Sequence of κ-opioid receptor cIDNA in the R1.1 thymoma cell line. J. Neuroimmunol. 62: 113-117.
41. 41. Lawrence, D.M. & J.M. Bidlack. 1993. The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein. J. Pharmacol. Exp. Ther. 266: 1678-1683.
42. 42. Joseph, D.B. & J.M. Bidlack. 1995. The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure. J. Pharmacol. Exp. Ther. 272: 970-976.
43. 43. Sedqi, M., S. Roy, S. Ramakrishnan & H.H. Loh. 1996. Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes. J. Neuroimmunol. 65: 167-170.
44. 44. Halford, W.P., B.M. Gerhardt & D.J.J. Carr. 1995. Functional role and sequence analysis of a lymphocyte orphan opioid receptor. J. Neuroimmunol. 59: 91-101.
45. 45. Carr, D.J.J., T.J. Rogers & R.J. Weber. 1996. The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis. Proc. Soc. Exp. Biol. Med. 113: 248-257.
46. 1 receptor. Nature 377: 532-535.
47. 47. Reinscheid, R.K., H.-P. Nothacker, A. Bourson, A. Ardati, R.A. Henningsen, J.R. Bunzow, D.K. Grandy, H. Langen, F.J. Monsma, Jr., O. Civelli & F.Q. Orphanin. 1995. A neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270: 792-794.
48. 48. Wick, M.J., S.R. Minnerath, S. Roy, S. Ramakrishnan & H.H. Loh. 1995. Expression of alternate forms of brain opioid "orphan" receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Mol. Brain. Res. 32: 342-347.
49. 49. Alvarez-Mon, A., J.H. Kehrl & A.S. Fauci. 1985. A potential role for adrenocorticotropin in regulating human B lymphocyte functions. J. Immunol. 135: 3823-3826.
50. 50. Brooks, K.H. 1990. Adrenocorticotropin (ACTH) functions as a late-acting B cell growth factor and synergizes with interleukin 5. J. Mol. Cell Immunol. 4: 327-335.
51. 51. Bost, K.L., B.L. Clarke, J. Xu, H. Kiyono, J.R. McGhee & D. Pascual. 1990. Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone. J. Immunol. 145: 4326-4331.
52. 52. Johnson, H.M., B.A. Torres, E.M. Smith, L.D. Dion & J.E. Blalock. 1984. Regulation of lymphokine (gamma-interferon) production by corticotropin. J. Immunol. 132: 246-250.
53. 53. Clarke, B.L. & K.L. Bost. 1989. Differential expression of functional adrenocorticotropic hormone receptors by subpopulations of lymphocytes. J. Immunol. 143: 464-469.
54. 54. Star, R.A., N. Rajora, J. Huang, R.C. Stock, A. Cattania & J.M. Lipton. 1995. Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. USA 92: 8016-8020.
55. 55. Fulop, Jr., T., D. Kekessy & G. Foris. 1987. Impaired coupling of naloxone sensitive opiate receptors to adenylate cyclase in PMNLs of aged male subjects. J. Immunopharmacol. 9: 651-658.
56. 56. Carr, D.J., K.L. Bost & J.E. Blalock. 1988. The production of antibodies which recognize opiate receptors on murine leukocytes. Life Sci. 42: 2615-2624.
57. + channels. Ann. N.Y. Acad. Sci. 540: 694-697.
58. 58. Hough, C.J., J.I. Halperin, D.L. Mazorow, S.L. Yeandle & D.B. Millar. 1990. β-Endorphin modulates T-cell intrucellular calcium flux and c-myc expression via a potassium channel. J. Neuroimmunol. 27: 163-171.
59. 59. Johnson, E.W., J.E. Blalock & E.M. Smith. 1988. ACTH receptor-mediated induction of leukocyte cyclic AMP. Biochem. Biophys, Res. Commun. 157: 1205-1211.
60. 60. Clarke, B.L., D.R. Moore & J.E. Blalock. 1994. Adrenocorticotropic hormone stimulates a transient calcium uptake in rat lymphocytes. Endocrinology 135: 1780-1786.
61. 61. Blalock, J.E. 1984, The immune system as a sensory organ. J. Immunol. 132: 1067-1070.
62. 62. Stein, C., A.H.S. Hassan, R. Przewlocki, C. Gramsch, K. Peter & A. Herz. 1990. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl. Acad. Sci. USA 87: 5935-5939.
63. 63. Schafer, M., S.A. Mousa, Q. Zhang, L. Carter & C. Stein. 1996. Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia. Proc. Natl. Acad. Sci. USA 93: 6096-6100.
64. 64. Carr, D.J., B.R. Decosta, A.E. Jacobson, K.C. Rice & J.E. Blalock. 1990. Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway. J. Neuroimmunol. 28: 53-61.
65. 65. Arakawa, K., T. Akami, M. Okamoto, T. Oka & H. Nagase. 1992. The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival. Transplantation 53: 951-953.
66. 66. Tian, M., H.E. Broxmeyer, Y. Fan, Z. Lai, S. Zhang, S. Aronica, S. Cooper, R.M. Bigsby, R. Steinmetz, S.J. Engle, A. Mestek, J.D. Pollock, M.N. Lehman, H.T. Jansen, M. Ying, P.J. Stambrook, J.A. Tischfield & L. Yu. 1997. Altered hematoipoiesis, behavior, and sexual function in μ opioid receptor-deficient mice. J. Exp. Med. 185: 1517-1522.
67. 67. Smith, E.M., P. Brosnan, W.J. Meyer & J.E. Blalock. 1987. An ACTH receptor on human mononuclear leukocytes. Relation to adrenal ACTH-receptor activity. New Eng. J. Med. 317: 1266-1269.
68. 68. Yamamoto, Y., Y. Kawaida, M. Noda, M. Yamagishi, O. Ishida, T. Fujihira, F. Shirakawa & I. Morimoto. 1995. Siblings with ACTH insensitivity due to lack of ACTH binding to the receptor. Endocrine J. 42: 171-177.