Evidence for the Differential Expression of the Functional α-Melanocyte-Stimulating Hormone Receptor MC-1 on Human Monocytes

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3378-3384

  Bhardwaj, Ranjit ^a   Becher, Eva ^a   Mahnke, Karsten ^a   Hartmeyer, Mechthild ^a   Schwarz, Thomas ^a   Scholzen, Thomas ^a   Luger, Thomas A ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN RECEPTOR; MELANOCORTIN RECEPTOR; RNA DIRECTED DNA POLYMERASE;

ARTICLE; BINDING SITE; BIOSYNTHESIS; DRUG EFFECT; HUMAN; METABOLISM; MONOCYTE; POLYMERASE CHAIN REACTION;

ALPHA-MSH; BINDING SITES; HUMANS; MONOCYTES; POLYMERASE CHAIN REACTION; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; RNA-DIRECTED DNA POLYMERASE;

EID: 0031110475     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Eberle, A. N. 1988. The Melanotropins. Karger, Basel.
2. Schauer, E., F. Trautinger, A. Köck, R. S. Bhardwaj, M. Simon, A. Schwarz, J. C. Ansel, T. Schwarz, and T. A. Luger. 1994. Proopiomelanocortin derived peptides are synthesized and released by human keratinocytes. J. Clin. Invest. 93:2258.
3. Morhenn, V. B. 1991. The physiology of scratching: involvement of proopiomelanocortin gene-coded proteins in Langerhans cells. Prog. Neurol. Endocrinol. Immun. 4:265.
4. Galin, F. S., R. D. LeBoeuf, and J. H. Blalock. 1991. Corticotropin-releasing factor upregulates expression of two truncated pro-opiomelanocortin transcripts in murine lymphocytes. J. Neuroimmunol. 31:51.
5. + dendritic cells express truncated form of POMC mRNA. Exp. Dermatol. 4:297.
6. Star, R. A., N. Rajora, J. Huang, R. Chavez, A. Catania, and J. M. Lipton. 1995. Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-MSH. Prof. Natl. Acad. Sci. USA 92:8016.
7. Robertson, B., K. Dostal, and R. A. Daynes. 1988. Neuropeptide regulation of inflammatory and immunologic responses: the capacity of alpha-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1 -inducible biologic responses. J. Immunol. 140:4300.
8. Luger, T. A., E. Schauer, F. Trautinger, J. Krulmann, J. Ansel, A. Schwarz, and T. Schwarz. 1993. Production of imrnunosuppressing melanotropins by keratinocytes. Ann. NY Acad. Sci. 680:567.
9. Hiltz, M. E., A. Catania, and J. M. Lipton. 1992. Alpha-MSH peptides inhibit acute inflammation induced in mice by rIL-1beta, rIL-6, rTNF-alpha and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8. Cytokine 4:320.
10. Bhardwaj, R. S., A. Schwarz, E. Becher, K. Mahnke, H. Riemann, Y. Aragane, T. Schwarz, and T. A. Luger. 1996. Proopiomeianocortin-derived peptides induce IL-10 production in human monocytes. J. Immunol. 156:2517.
11. Catania, A., and J. M. Lipton. 1993. Alpha-melanocyte stimulating hormone in the modulation of host reactions. Endocr. Rev. 14:564.
12. Hiltz, M. E., and J. M. Lipton. 1990. Alpha-MSH peptides inhibit acute inflammation and contact sensitivity. Peptides 11:979.
13. Grabbe, S., R. S. Bhardwaj, M. Steinert, K. Mahnke, M. M. Simon, T. Schwarz, and T. A. Luger. 1996. Alpha-melanocyte stimulating hormone induces hapten-specific tolerance in mice. J. Immunol. 156:473.
14. Mountjoy, K. G., L. S. Robbins, M. T. Mortrud, and R. D. Cone. 1992. The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248.
15. Chhajlani, V., and J. E. Wikberg. 1992. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett 309:417.
16. Chhajlani, V., R. Muceniece, and J. E. Wikberg. 1993. Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. 195:866.
17. Haskell Luevano, C., H. Miwa, C. Dickinson, V. J. Hruby, T. Yamada, and I. Gantz. 1994. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochem. Biophys. Res. Commun. 204:1137.
18. Mountjoy, K. G. 1994. The human melanocyte stimulating hormone receptor has evolved to become "super-sensitive" to melanocortin peptides. Mol. Cell. Endocrinol. 102:R7.
19. Mountjoy, K. G., M. T. Mortrud, M. J. Low, R. B. Simerly, and R. D. Cone. 1994. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomie control circuits in the brain. Mol. Endocrinol. 8:1298.
20. Gantz, I., Y. Shimoto, Y. Konda, H. Miwa, C. J. Dickinson, and T. Yamada. 1994. Molecular cloning, expression, and characterization of a fifth melanocortin receptor. Biochem. Biophys. Res. Commun. 200:1214.
21. Cone, R. D., and K. G. Mountjoy. 1992. Cloning and functional characterization of human adrenocorticotropin receptor. In Cellular and Molecular Biology of the Adrenal Cortex, Ed. A. Capponi, E. M. Chambaz and F. Mantero, eds. J. Libbey Eurotext, Paris, p. 27.
22. Gantz, I., T. Tashiro, C. Barcroft, Y. Konda, Y. Shimoto, H. Miwa, T. Glover, G. Munzert, and T. Yamada. 1993. Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization. Genomics 18:166.
23. Gantz, I., H. Miwa, Y. Konda, Y. Shimoto, T. Tashiro, S. J. Watson, J. DelValle, and T. Yamada. 1993. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268:15174.
24. Rajora, N., G. Ceriani, A. Catania, R. A. Star, M. T. Murphy, and J. M. Lipton. 1996. α-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line. J. Leukocyte Biol. 59:248.
25. Bhardwaj, R. S., E. Becher, K. Mahnke, M. Hartmeyer, T. Scholzen, T. Schwarz, and T. A. Luger. 1996. Evidence of the expression of a functional melanocortin receptor 1 by human keratinocytes. J. Invest. Dermatol. 106:817.
26. Aebischer, I., M. R. Stämpfli, A. Zürcher, S. Miescher, A. Urwyler, B. Frey, T. A. Luger, R. R. White, and B. M. Stadler. 1994. Neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis. Eur. J. Immunol. 24:1908.
27. Bhardwaj, R. S., C. Zotz, G. Zwadlo Klarwasser, J. Roth, M. Goebeler, K. Mahnke, M. Falk, G. Meinardus Hager, and C. Sorg. 1992. The calcium-binding proteins MRP8 and MRP14 form a membrane-associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions. Eur. J. Immunol. 22:1891.
28. Catania, A., and J. M. Lipton. 1994. The neuropeptide alpha-melanocyte-stimulating hormone: a key component of neuroimmunomodulation. Neuroimmunomodulation 1:93.
29. Triggle, D. J. 1982. Receptor recruitment and cryptic signals. Trends Pharmacol. Sci. 3:273.
30. Eberle, A. N., W. Siegrisi, C. Bagutti, J. Chluba De Tapia, F. Solca, J. E. Wikberg, and V. Chhajlani. 1993. Receptors for melanocyte-stimulating hormone on melanoma cells. Ann. NY Acad. Sci. 680:320.
31. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319.
32. Christou, N. V., J. A. Mannick, M. A. West, and D. L. Kasper. 1987. Lymphocyte macrophage interactions in the response to surgical infections. Arch. Surg. 122: 239.
33. Drysdale, B. E., S. Agarwal, and H. S. Shin. 1988. Macrophage-mediated tumoricidal activity, mechanisms of activation and cytotoxicity. Prog. Allergy 40: 111.
34. Bonta, I. L., and S. Ben Efraim. 1993. Involvement of inflammatory mediators in macrophage antitumor activity. J. Leukocyte Biol. 54:613.
35. Zwadlo, G., R. Schlegel, and C. Sorg. 1986. A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J. Immunol. 137:512.
36. Hoffman, T., C. Brando, E. F. Lizzio, Y. L. Lee, M. Hansen, A. K. Tripathi, M. Taplits, J. Puri, E. Bonvini, T. G. Abrahamsen, C. S. Carter, G. K. Reid, and J. Evans. 1991. Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro: synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release. J. Immunol. 146:692.
37. Kirkland, T. N., F. Finley, D. Leturcq, A. Moriarty, J. D. Lee, R. J. Ulevitch, and P. S. Tobias. 1993. Analysis of lipopolysaccharide binding by CD14. J. Biol. Chem. 268:24818.
38. Couturier, C., G. Jahns, M. D. Kazatchkine, and N. Haeffner Cavaillon. 1992. Membrane molecules which !rigger the production of interleukin-1 and tumor necrosis factor-alpha by lipopolysaccharide-stimulated human monocytes. Eur. J. Immunol. 22:1461.
39. Hart, P. H., G. F. Vitti, D. R. Burgess, G. A. Whitty, D. S. Piccoli, and J. A. Hamilton. 1989. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Proc. Natl. Acad. Sci. USA 86:3803.
40. Del Preie, G. F., M. De Carli, M. M. D'Elios, P. Maestrelli, M. Ricci, L. Fabbri, and S. Romagnani. 1993. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur. J. Immunol. 23:1445.
41. Hermus, A. R., and C. G. Sweep, 1990. Cytokines and the hypothalamic-pituitary-adrenal axis. J. Steroid Biochem. Mol. Biol. 37:867.
42. Blalock, J. E. 1994. The syntax of immune-neuroendocrine communication. Immunol. Today 15:504.
43. Wintzen, M., and B. A. Gilchrest. 1996. Proopiomelanocortin, its derived peptides, and the skin. J. Invest. Dermatol. 106:3.
44. Kock, A., E. Schauer, T. Schwarz, and T. A. Luger. 1991. Human keratinocytes synthesize and release neuropeptides such as α-MSH and ACTH. In Cellular and Cytokine Networks in Tissue Immunity. M. Meltzer and A. Mantovani, eds. John Wiley and Sons, Inc., New York, p. 105.
45. Uhler, M., and E. Herbert. 1983. Complete amino acid sequence of mouse proopiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA. J. Biol. Chem. 258:257.
46. Gantz, I., Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S. J. Watson, J. DelValle, and T. Yamada. 1993. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268:8246.
47. Fathi, Z., L. G. Iben, and E. M. Parker. 1995. Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem. Res. 20:107.
48. Azuma, M., D. Ito, H. Yagita, K. Okumura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 und CD28. Nature 366:76.
49. Catania, A., V. Gerloni, S. Procaccia, L. Airaghi, M. G. Manfredi, C. Lomater, L. Grossi, and J. M. Lipton. 1994. The anticytokine neuropeptide alpha-melanocyte-stimulating hormone in synovial fluid of patients with rheumatic diseases: comparisons with other anticytokine molecules. Neuroimmunomodulation. 1:321.
50. Smith, E. M., T. K. J. Hughes, F. Hashemi, and G. B. Stefane. 1992. Immunosuppressive effects of corticotropin and melanotropin and their possible significance in human immunodeficiency virus infection. Proc. Natl. Acad. Sci. USA 89:782.
51. Lipton, J. M., G. Ceriani, A. Macaluso, D. McCoy, K. Carnes, J. Biltz, and A. Catania. 1994. Antiinflammatory effects of the neuropeptide alpha-MSH in acute, chronic, and systemic inflammation. Ann. NY Acad. Sci. 741:137.
52. Catania, A., M. G. Manfredi, L. Airaghi, M. C. Vivirito, A. Capetti, F. Milazzo, J. M. Lipton, and C. Zanussi. 1994. Plasma concentration of cytokine antagonists in patients with HIV infection. Neuroimmunomodulation 1:42.
53. Duvaux Miret, O., G. B. Stefano, E. M. Smith, C. Dissous, and A. Capron. 1992. Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoactive neuropeptides. Proc. Natl. Acad. Sci. USA 89:778.
54. Catania, A., L. Airaghi, M. G. Manfredi, M. C. Vivirito, F. Milazzo, J. M. Lipton. and C. Zanussi. 1993. Proopiomelanocortin-derived peptides and cytokines: relations in patients with acquired immunodeficiency syndrome. Clin. Immunol. Immunopathol. 66:73.
55. Gonindard, C., C. Goigoux, E. Hollande, and L. Dussourd D'Hinterland. 1996. The administration of an a-MSH analogue reduces the serum release of IL-1α and TNFα induced by the injection of a sublethal dose of lipopolysaccharides in the BALB/c mouse. Pigment Cell Res. 9:148.
56. Waldmann, H., and S. Cobbold. 1993. The use of monoclonal antibodies to achieve immunological tolerance. Immnnol. Today 14:247.