Pro-opiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes

Journal of Investigative Dermatology

Volumn 114, Issue 3, 2000, Pages 430-437

  Peters, Eva M J ^c   Tobin, Desmond J ^c   Seidah, Nabil G ^a   Schallreuter, Karin U ^b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c NONE

Author keywords

Melanocyte; Melanogenesis; Prohormone convertases; melanocyte stimulating hormone

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; CORTICOTROPIN[18-39]; CORTICOTROPIN[4-10]; FURIN; MELANIN; MONOPHENOL MONOOXYGENASE; PROOPIOMELANOCORTIN; TETRAHYDROBIOPTERIN;

ALLOSTERISM; ARTICLE; FEMALE; HORMONAL REGULATION; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOSOME; PIGMENTATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATORY MECHANISM;

EID: 3142632953     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00913.x     Document Type: Article

References (58)

1. Abdel-Malek Z, Swope VB, Suzuki I, et al: Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 92:1789-1793, 1995
2. Abou-Donia MM, Wilson SP, Zimmerman TP, Nichol CA, Viveros OH: Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. J Neurochem 46:1190-1199, 1986
3. Albert KA, Helmer-Matyjek E, Nairn AC, et al: Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proc Natl Acad Sci USA 81:7713-7717, 1984
4. Benjannet S, Savaria D, Chrétien M, Seidah NG: 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. J Neurochem 64:2303-2311, 1995
5. Benjannet S, Mamarbachi M, Hamelin J, Savaria D, Munzer JS, Chrétien M, Seidah NG: Residues unique to the prohormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity. FEBS Lett 428:37-42, 1998
6. Botchkarev VA, Eichmüller S, Peters EM, Pietsch P, Johansson O, Maurer M, Paus R: A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle-dependent changes in mast cell-nerve fiber contacts in murine skin. Arch Dermatol Res 289:292-302, 1997
7. Braks JA, Martens GJM: 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. Cell 78:263-273, 1994
8. Burchill SA, Thody AJ: Melanocyte-stimulating hormone and the regulation of tyrosinase activity in hair follicular melanocytes of the mouse. J Endocrinol 111:225-232, 1986
9. Can G, Abdel-Malek Z, Porter-Gill PA, et al: Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture. J Invest Dermatol 111:485-491, 1998
10. Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek JM, Ichihashi M: Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochim Biophys Acta 1313:130-138, 1996
11. Donatien PD, Hunt G, Pieron C, Lunec J, Taieb A, Thody AJ: The expression of functional MSH receptors on cultured human melanocytes. Arch Dermatol Res 284:424-426, 1992
12. Farooqui JZ, Medrano EE, Abdel-Malek Z, Nordlund J: The expression of proopiomelanocortin and various POMC-derived peptides in mouse and human skin. Ann N Y Acad Sci 680:508-510, 1993
13. Friedmann PS, Wren F, Buffey J, Macneil S: Alpha-MSH causes a small rise in cAMP but has no effect on basal or ultraviolet-stimulated melanogenesis in human melanocytes. Br J Dermatol 123:145-151, 1990
14. Gabreels BA, Swaab DF, de Kleijn DP, et al: Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect. J Clin Endocrinol Metab 83:591-599, 1998
15. Hill SE, Buffey J, Thody AJ, Oliver I, Bleehen SS, MacNeil S: Investigation of the regulation of pigmentation in alpha-melanocyte-stimulating hormone responsive and unresponsive cultured B16 melanoma cells. Pigment Cell Res 2:161-166, 1989
16. lozumi K, Hoganson GE, Pennella R, Everett MA, Fuller BB: Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes. J Invest Dermatol 100:806-811, 1993
17. Iwata M, Corn T, Iwata S, Everett MA, Fuller BB: The relationship between tyrosinase activity and skin color in human foreskins. J Invest Dermatol 95:9-15, 1990
18. Jackson RS, Creemers JW, Ohagi S, et al: Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303-306, 1997
19. Jean F, Basak A, Rondeau N, et al: Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. Biochem J 292:891-900, 1993
20. Jimbow K, Quevedo WC, Fitzpatrick TB, Szabó G. Biology of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Flusten KF (eds). Dermatology in General Medicine. New York: McGraw-Hill Inc., pp 261-289, 1971
21. Karnovsky MJA: Formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J Cell Biol 27:137-138a, 1965
22. Lamango NS, Zhu X, Lindberg I: Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2. Arch Biochem Biophys 330:238-250, 1996
23. Lamango NS, Apletalina E, Liu J, Lindberg I: The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process. Arch Biochem Biophys 362:275-282, 1999
24. Lerner AB: The discovery of the melanotropins. A history of pituitary endocrinology. Ann N Y Acad Sci 680:1-12, 1993
25. Lerner AB, McGuire JS: Effect of alpha and beta melanocyte stimulating hormones on skin color of man. Nature 189:176-179, 1961
26. Lindberg I: Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum. Mol Cell Neurosci 5:263-268, 1994
27. Marles LK, Hibberts NA, Peters EMJ, Tobin DJ, Schallreuter KU: Tyrosine hydroxylase isozyme I is present in human melansomes. J Invest Dermatol (submitted), 1999
28. Moore J, Wood JM, Schallreuter KU: Evidence for specific complex formation between α-melanocyte stimulating hormone and 6(R) -L-erythro 5,6,7,8 tetrahydrobiopterin using near infrared Fourier Transform Raman spectroscopy. Biochemistry 38:15317-15324, 1999
29. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD: The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251, 1992
30. Müller L, Zhu X, Lindberg I: Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding. J Cell Biol 139:625-638, 1997
31. Pawelek JM: Studies on the Cloudman melanoma cell line as a model for the action of MSH. Yale J Biol Med 58:571-578, 1985
32. Pittelkow MR, Shipley GD: Serum-free culture of normal human melanocytes: growth kinetics and growth factor requirements. J Cell Physiol 140:565-576, 1989
33. Roebroek AJ, Dehaen MR, van Bokhoven A, Martens GJ, Marynen P, van den Berghe H, Van de Ven WJ: Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13-q14 by in situ hybridization. Cytogenet Cell Genet 50:158-160, 1989
34. Schallreuter KU, Büttner G, Pittelkow MR, Wood JM, Swanson NN, Körner C: Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun 204:43-48, 1994
35. Schallreuter KU, Schulz-Douglas Bünz V, Beazley A, Körner WD: Pteridines in the control of pigmentation. J Invest Dermatol 109:31-35, 1997
36. Schallreuter KU, Beazley WD, Hibberts NA, Swanson NN, Pittelkow MR: Perturbed epidermal pterin metabolism in Hermansky-Pudlak syndrome. J Invest Dermatol 111:511-516, 1998
37. Schallreuter KU, Moore J, Tobin DJ, et al: α-MSH can control the essential cofactor 6-tetrahydrobiopterin in melanogenesis. Ann N Y Acad Sci 885:329-341, 1999
38. Schauer E, Trautinger F, Köck A, et al: Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 93:2258-2262, 1994
39. Schmidt WK, Moore HP: Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells. Mol Biol Cell 6:1271-1285, 1995
40. Seidah NG, His KL, De Serres G, et al: Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily: Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. Arch Biochem Biophys 225:525-534, 1983
41. Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell Biol 9:415-424, 1990
42. Seidah NG, Marcinkiewicz M, Benjannet S, et al: Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol 5:111-122, 1991
43. Seidah NG, Day R, Marcinkiewicz M, Chretien M: Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins. Ann N Y Acad Sci 839:9-24, 1998
44. Slominski A, Pawelek J: Animals under the sun: effects ultraviolet radiation on mammalian skin. Clin Dermatol 16:503-515, 1998
45. Slominski A, Paus R, Mazurkiewicz J: Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48:50-54, 1992
46. Thody AJ: a-MSH and the regulation of melanocyte function. Ann N Y Acad Sci 885:217-229, 1999
47. Thody AJ, Graham A: Does alpha-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res 11:265-274, 1998
48. Thody AJ, Ridley K, Penny RJ, Chalmers R, Fisher C, Shuster S: MSH peptides are present in mammalian skin. Peptides 4:813-816, 1983
49. Tobin DJ: Morphological analysis of hair follicles in acute alopecia areata. Micros Res Tech 38:443-451, 1997
50. Tobin DJ, Colen SR, Bystryn JC: Isolation and long-term culture of human hair-follicle melanocytes. J Invest Dermatol 104:86-89, 1995
51. Valverde P, Healy E, Jackson I, Rees JL, Thody AJ: Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 11:328-330, 1995
52. Van Horssen AM, Martens GJ: Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC2. Mol Cell Endocrinol 137:7-12, 1998
53. Wakamatsu K, Graham A, Cook D, Thody AJ: Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 10:288-297, 1997
54. Wintzen M, Gilchrest BA: Proopiomelanocortin, its derived peptides, and the skin. J Invest Dermatol 106:3-10, 1996
55. Wood JM, Schallreuter-Wood KU, Lindsey NJ, Callaghan S, Gardner ML: A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Biochem Biophys Res Communs 106:480-485, 1995
56. Yaswen L, Diehe N, Miles B, Hochgeschwender B, Hochgeschwender U: Obesity in the mouse model of proopiomelanocortin deficiency responds to peripheral melanocortin. Nature Med 5:1066-1071, 1999
57. Zhou A, Mains RE: Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2. J Biol Chem 269:17440-17447, 1994
58. Zhou Y, Lindberg I: Purification and characterization of the prohormone convertase PC1 (PC3). J Biol Chem 268:5615-5623, 1993