Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: Expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 471, Issue 1-2, 2000, Pages 135-143

  Kushida, Hirotaka ^a   Fujita, Ken Ichi ^a   Suzuki, Akihiro ^a   Yamada, Masami ^b   Nohmi, Takehiko ^b   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Heterologous expression; Metabolic activation; Mutation assay; YG7108

Indexed keywords

ALKANONE; ANILINE DERIVATIVE; COMPLEMENTARY DNA; CYTOCHROME; DIETHYLNITROSAMINE; NITROSAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; CONTROLLED STUDY; FEMALE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MUTAGENICITY TESTS; MUTAGENS; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITROSAMINES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALMONELLA TYPHIMURIUM; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY;

ADA; SALMONELLA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034694174     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00117-0     Document Type: Article

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