Metabolism of 4-(methylnitrosammo)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate

Carcinogenesis

Volumn 17, Issue 4, 1996, Pages 809-813

  Smith, Theresa J ^a   Guo, Zuyu ^b   Guengerich, F Peter ^b   Yang, Chung S ^a  

^a RUTGERS UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ALCOHOL; CYTOCHROME P450; ISOTHIOCYANIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CARCINOGENICITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LIVER MICROSOME; METABOLISM; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TOBACCO;

CARCINOGENS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; ISOTHIOCYANATES; MICROSOMES, LIVER; NITROSAMINES; OXIDOREDUCTASES; SUBSTRATE SPECIFICITY;

EID: 0029986896     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.4.809     Document Type: Article

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