Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation

Journal of Investigative Dermatology

Volumn 117, Issue 6, 2001, Pages 1412-1420

  Scott, Glynis ^a   Deng, April ^a   Rodriguez Burford, Cristina ^c   Seiberg, Miri ^b   Han, Rujing ^a   Babiarz, Laura ^b   Grizzle, William ^c   Bell, William ^c   Pentland, Alice ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Skin Biology Research Center   (United States)

^c UNIVERSITY OF ALABAMA   (United States)

Author keywords

Keratinocytes; Melanosome; Protease activated receptor 2 (PAR 2); UV irradiation

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2;

ADULT; AGED; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; EPIDERMIS; ERYTHEMA; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; KERATINOCYTE; MALE; MELANOSOME; NEWBORN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIATION DOSE; RECEPTOR UPREGULATION; SIMULATOR; SKIN; SKIN BIOPSY; SKIN PIGMENTATION; SUPERNATANT; TISSUE TYPES; ULTRAVIOLET IRRADIATION;

EID: 0035678081     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01575.x     Document Type: Article

References (60)

1. Nepriolysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins
2. Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction
3. Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family
4. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
5. Mechanisms of desensitization and resensitization of proteinase-activated receptor-2
6. Molecular cloning, expression and potential function of the human proteinase-activated receptor-2
7. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
8. A study of pigment donation in vitro
9. Mast cell tryptase regulates colonic myocytes through proteinase-activated receptor-2
10. Microwave antigen retrieval in immunocytochemistry: A study of 80 antibodies
11. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues
12. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors
13. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
14. Evaluation of proliferating cell nuclear antigen as a surrogate end point biomarker in actinic keratosis and adjacent, normal-appearing, and non-sun-exposed human skin samples
15. The validity and practicality of sun-reactive skin type I through VI
16. DNA photodamage stimulates melanogenesis and other photoprotective responses
17. The human sunburn reaction: Histologic and biochemical studies
18. Factors affecting immunohistochemical evaluation of biomarker expression in neoplasia
19. High levels of p53 protein in UV-irradiated normal skin
20. Growth and differentiation of mouse epidermal cells in culture: Effects of extracellular calcium
21. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
22. Proteinase-activated receptors (PARs): Activation of PAR1 and PAR2 proteolytic fragment of the neuronal growth associated protein B-50/GAP-43
23. Immunolocalization of protease-activated receptor-2 in skin: Receptor activation stimulates interleukin- 8 secretion by keratinocytes in vitro
24. Protease-activated receptor 3 is a second thrombin receptor in human
25. The roles of keratinocyte-derived cytokines in the epidermis and their possible responses to UVA-irradiation
26. Luminal trypsin may regulate enterocytes through proteinase-activated receptor-2
27. Delayed onset of inflammation in protease-activated receptor-2-deficient mice
28. Cleavage and activation of proteinase-activated receptor-2 on human neutraphils by gingipain-R from Porphyromonas gingivalis
29. Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma
30. 2+ mobilization in human T-cell lines through interaction with different proteinase-activated receptors
31. Interactions of mast cell tryptase with thrombin receptor and PAR-2
32. Melanosome capping of keratinocytes in pigmented reconstructed epidermis: Effect of ultraviolet irradiation and 3-isobutyl-1-methyl-xanthine on melanogenesis
33. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
34. Molecular cloning of a potential proteinase activated receptor
35. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
36. The mouse proteinase-activated receptor-2 cDNA and gene: Molecular cloning and functional expression
37. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells
38. An alternative approach to depigmentation by soybean extracts via inhibition of the PAR-2 pathway
39. Signaling pathways mediating melanogenesis
40. The effect of a single dose of ultraviolet irradiation on epidermal melanocytes
41. Sunlight and melanin pigmentation
42. Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes
43. Reaction of mast cell protease and chymase with proteinase-activated receptors (PARs) on keratinocytes and fibroblasts
44. Keratinocytes regulate melanocyte number in human fetal and neonatal skin equivalents
45. The protease-activated receptor-2 regulates pigmentation via keratinocyte-melanocyte interactions
46. Inhibition of melanosome transfer results in skin lightening
47. The protease activated receptor-2 upregulates keratinocyte phagocytosis
48. Protease-activated receptor-2 (PAR-2) is present in the rat hippocampus and is associated with neurodegeneration
49. Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: Evidence of a proteinase specifically expressed in keratinizing squamous epithelia
50. Acute effects of ultraviolet irradiation on the skin
51. Protease-activated receptor-2 in human skin: Tissue distribution and activation of keratinocytes by mast cell tryptase
52. Human pigmentation genes and their response to solar UV irradiation
53. The immunohistochemical effects of a single challenge with an intermediate dose of ultraviolet B on normal human skin
54. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
55. Thrombin and trypsin stimulate granulocyte macrophage-colony stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes
56. Melanocyte-keratinocyte interactions in vivo: The fate of melanosomes
57. Cloning and characterization of human protease-activated receptor 4
58. Three models of melanosome transfer in Caucasian facial skin: Hypothesis based on an ultrastructural study
59. cDNA cloning and expression of a novel serine protease, TLSP
60. Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kalikrein gene family