An alternative approach to depigmentation by soybean extracts via inhibition of the PAR-2 pathway

Journal of Investigative Dermatology

Volumn 116, Issue 4, 2001, Pages 587-595

  Paine, C ^a   Sharlow, E ^a   Liebel, F ^a   Eisinger, M ^a   Shapiro, S ^a   Seiberg, M ^a  

^a Skin Biology Research Center   (United States)

Author keywords

Keratinocyte; Melanocyte; Skin lightening; Soymilk; STI

Indexed keywords

BOWMAN BIRK INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 2; SERINE PROTEINASE INHIBITOR; SOYBEAN PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DEPIGMENTATION; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOCYTE; MELANOSOME; MILK; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN COLOR; SOYBEAN MILK; SWINE; ULTRAVIOLET B RADIATION;

EID: 0035046316     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01291.x     Document Type: Article

References (39)

1. Cardiovascular and renal benefits of dry bean and soybean intake
2. A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor
3. The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans
4. Molecular cloning, expression and potential functions of the human proteinase activated receptor 2
5. Potent thrombin inhibitors that probe the S1′ subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group 1
6. Differential regulation of human keratinocyte growth and differentiation by a novel family ofprotease-activated receptors
7. Proteinase-activated receptors: A growing family of heptahelical receptors for thrombin, trypsin and tryptase
8. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
9. Soybean (malonyl) isoflavones characterization and antioxidant properties
10. Human skin proteinases as inflammatory mediators
11. Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: Effect of depigmenting agents
12. Proteinase-activated receptor-2 in rat aorta: Structural requirements for agonist activity of receptor-activating peptides
13. Protease-activated receptor 3 is a second thrombin receptor in humans
14. Chemical, pharmacologic and physical agents causing hypomelanoses
15. The Bowman-Birk inhibitor from soybeans as an anticarcinogenic agent
16. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse
17. Effects of thermal processing on soymilk
18. Soy protein, isoflavones and cardiovascular disease risk
19. Chemistry, and nutritional value of soybean components
20. Trypsin inhibition by free fatty acids and stearol-CoA
21. Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from porphyromonas gingivalis
22. A secreted serine protease can induce apoptosis in Pam12 keratinocytes
23. Influence of nonionic liposomal composition on topical delivery of peptide drugs into pilosebaceous units: An in vivo study using the hamster ear model
24. Molecular cloning of a potential proteinase activated receptor
25. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
26. The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression
27. Melanins and melanocytes, form and function
28. The enzymology of melanogenesis
29. Temporal separation of rhabdom shrinkage and MVB formation in the light-adapting crayfish retina
30. Evidence for the presence of a protease-activated receptor distinct from thrombin receptor in human keratinocytes
31. PAR-2 regulates pigmentation via keratinocyte-melanocyte interactions
32. Inhibition of melanosome transfer results in skin lightening
33. The protease activated receptor-2 upregulates keratinocyte phagocytosis
34. Kunitz-type soybean trypsin inhibitor revisited: Refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from erythrina caffra and tissue-type plasminogen activator
35. Potential health benefits of dietary phytoestrogens: A review of the clinical, epidemiological, and mechanistic evidence
36. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
37. Studies on the processing and properties of soymilk. II. Effect of processing conditions on the trypsin inhibitor activity and the digestibility in vitro of proteins in various soymilk preparations
38. Cloning and characterization of human protease-activated receptor-4