The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma

Inflammation Research

Volumn 50, Issue 12, 2001, Pages 616-624

  Tanaka, H ^a   Masuda, T ^a   Tokuoka, S ^a   Komai, M ^a   Nagao, K ^a   Takahashi, Y ^a   Nagai, H ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Airway inflammation; Bronchial hyperresponsiveness; Goblet cells; Subepithelial fibrosis; TGF 1

Indexed keywords

ACETYLCHOLINE; COLLAGEN; HYDROXYPROLINE; IMMUNOGLOBULIN E; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CELL COUNT; CONTROLLED STUDY; CORRELATION FUNCTION; EOSINOPHIL; FEMALE; HISTOLOGY; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MOUSE; NONHUMAN; PROVOCATION TEST;

ACETYLCHOLINE; ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; COLLAGEN; CYTOKINES; EPITHELIAL CELLS; FEMALE; HYDROXYPROLINE; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; LUNG; MICE; MICE, INBRED BALB C; RESPIRATORY SYSTEM; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035661260     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000243     Document Type: Article

References (37)

1. The role of mucosal inflammation in asthma
2. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: A quantitative light and electron microscopy study
3. Subepithelial fibrosis in the bronchi of asthmatics
4. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack
5. Hyperplasia of bronchial muscle in asthma
6. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: A 3-D morphometric study
7. Airway remodeling in asthma
8. Airway remodeling and repair
9. Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice
10. Time course study for antigen-induced airway hyperreactivity and the effect of soluble IL-5 receptor
11. Prostaglandin D2 as a mediator of allergic asthma
12. Lung inflammation and epithelial changes in a murine model of atopic asthma
13. An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen
14. Bronchial hyperresponsiveness and airway wall remodelling induced by exposure to allergen for 9 weeks
15. Prolonged allergen exposure induces structural airway changes in sensitized rats
16. The effect of anti-IL-4 monoclonal antibody, rapamycin and interferon-γ on airway hyperreactivity to acetylcholine in mice
17. Effect of anti-IL-4 and anti-IL-5 antibodies on allergic airway hyperresponsiveness in mice
18. Suppressive effects of tranilast on pulmonary fibrosis and activation of alveolar macrophages in mice treated with bleomycin: Role of alveolar macrophages in the fibrosis
19. Modifications of a specific assay for hydroxyproline in urine
20. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats
21. Airway inflammation and remodeling in asthma
22. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma
23. Eosinophil-associated TGF-betal mRNA expression and airways fibrosis in bronchial asthma
24. Expression of growth factors and remodelling of the airway wall in bronchial asthma
25. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease
26. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
27. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
28. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
29. Transforming growth factor-β in tissue fibrosis
30. Role of transforming growth factor-β in human disease
31. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and III collagen and fibronectin mRNAs in normal human dermal fibroblasts
32. Growth factors in the regulation of pericellular proteolysis: A review
33. Cytokines and pulmonary fibrosis
34. Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1)
35. +T cells ameliorates antigen-induced eosinophilic inflammation: A novel high-dose tolerance in the trachea
36. Transforming growth factor-beta in normal human lung: Preferential location in bronchial epithelial cells
37. Role of transforming growth factor β in human disease