Transepithelial sodium and water transport in the lung: Major player and novel therapeutic target in pulmonary edema

Advances in Experimental Medicine and Biology

Volumn 502, Issue , 2001, Pages 315-338

  Sartori, Claudio ^a,b   Matthay, Michael A ^b   Scherrer, Urs ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute lung injury; Alveolar epithelium; Alveolar fluid clearance; Aquaporins; Epithelial sodium channels; Hypoxia; Na K ATPase; Pulmonary edema; Transepithelial sodium transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADRENALIN; AMILORIDE; ANTIPORTER; AQUAPORIN; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BLEOMYCIN; CARRIER PROTEIN; CATECHOLAMINE; CHLORIDE ION; CYTOKINE; DEXAMETHASONE; DOPAMINE; GLUCOCORTICOID; GROWTH FACTOR; HORMONE; ISOPRENALINE; KERATINOCYTE GROWTH FACTOR; METHYLPREDNISOLONE SODIUM SUCCINATE; NITRIC OXIDE; SALBUTAMOL; SALMETEROL; SCATTER FACTOR; SODIUM ION; TERBUTALINE; THIOUREA; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNINDEXED DRUG; VASOACTIVE AGENT;

APICAL MEMBRANE; BASOLATERAL MEMBRANE; CONFERENCE PAPER; DISEASE SEVERITY; DRUG EFFECT; DRUG TARGETING; FLUID BALANCE; GENE THERAPY; GENE TRANSFER; HUMAN; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG EDEMA; LUNG FLUID; LUNG INJURY; MEMBRANE DAMAGE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; REGULATORY MECHANISM; SIDE EFFECT; SODIUM TRANSPORT; WATER TRANSPORT;

ANIMALS; AQUAPORINS; HUMANS; LUNG; PULMONARY ALVEOLI; PULMONARY EDEMA; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MUCOSA; SODIUM; SODIUM CHANNELS; WATER;

EID: 0035574867     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4757-3401-0_21     Document Type: Article

References (140)

1. Aerosolized beta2-agonists achive therapeutic levels in the pulmonary edema fluid of ventilated patients
2. Adenoviral mediated overexpression of the Na-K-ATPase alpha 2 isoform increases alveolar fluid reabsorption in rats
3. Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia
4. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice
5. Regional bioelectric properties of porcine airway epithelium
6. Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice
7. Decreased sodium ion transport across nasal epithelium of very premature infants with respiratory distress syndrome
8. Development of the lung liquid reabsorptive mechanism in fetal sheep: Synergism of triiodothyronine and hydrocortisone
9. Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium
10. Alveolar liquid and protein clearance from normal dog lungs
11. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep
12. Isoproterenol increases Na+-K+-ATPase activity by membrane insertion of alpha-subunits in lung alveolar cells
13. Chronic hypoxia increases beta-adrenergic receptor density in the lungs of young and old rats
14. Alveolar epithelial type I cells express sodium transport proteins
15. Effects of EGF on alveolar epithelial junctional permeability and active sodium transport
16. KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells
17. Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep
18. Autoradiographic visualization of beta-adrenoceptor subtypes in human lung
19. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method
20. Effect of epinephrine on alveolar liquid clearance in the rat
21. Hypoxia regulates gene expression of alveolar epithelial transport proteins
22. Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: Biological and clinical significance
23. Effects of terbutaline on sodium transport in isolated perfused rat lung
24. Highly water-permeable type I alveolar epithelial cells confer high transalveolar water permeability between the airspace and vasculature in rat lung
25. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung
26. Delayed resolution of thiourea-induced pulmonary edema in mice with defective sodium transport-dependent alveolar fluid clearance
27. Intravenous keratinocyte growth factor stimulates alveolar fluid clearance and accelerates the resolution of thiourea-induced pulmonary edema in mice
28. Impaired alveolar fluid clearance and augmented susceptibility to lung edema in mice with defective amiloride sensitive sodium transport
29. Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. I. Analysis, characterization and regulation of specific beta adrenergic receptors
30. Overexpression of the beta2-adrenergic receptor increases lung liquid clearance by increasing sensitivity to endogenous catecholamines in rats
31. Adenoviral-mediated overexpression of the NA, K-ATPase beta1 subunit gene increases lung edema clearance and improves survival during acute hyperoxic lung injury in rats
32. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na, K-ATPase beta1 subunit gene
33. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels
34. Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin
35. Salt and water transport across the alveolar epithelium in the developing lung: Correlations between function and recent molecular biology advances
36. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats
37. Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats
38. Ventilator-associated lung injury: Does low tidal volume ventilation protect the alveolar epithelial barrier in a rat model of acid-induced lung injury
39. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats
40. CFTR controls cAMP-regulated isoosmolar alveolar fluid transport in the distal airspaces of the mouse lung
41. Relationship of interstitial fluid volume to alveolar fluid clearance in mice: Ventilated vs. in situ studies
42. Overexpression of the beta-2 adrenergic receptor in alveolar type II cells upregulates alveolar epithelial fluid transport in mice
43. New in situ mouse model to quantify alveolar epithelial fluid clearance
44. Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats
45. Alveolar endotoxin increases alveolar liquid clearance in rats
46. Evidence for regulation of sodium transport from airspace to vascular space by cAMP
47. Evidence for active sodium transport across alveolar epithelium of isolated rat lung
48. Electrical potential difference and ion transport across nasal epithelium of term neonates: Correlation with mode of delivery, transient tachypnea of the newborn, and respiratory rate
49. Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs
50. Intravenous keratinocyte growth factor protects against experimental pulmonary injury
51. Nitric oxide inhibits Na+ absorption across cultured alveolar type II monolayers
52. Possible role of ROS as mediators of hypoxia-induced ion transport inhibition of alveolar epithelial cells
53. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
54. A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism
55. Regulation of ion transport across porcine distal bronchi
56. Alveolar liquid and protein clearance in anesthetized ventilated rats
57. Adrenergic stimulation of Na+ transport across alveolar epithelial cells involves activation of apical Cl- channels
58. A novel role for cyclic nucleotide-gated cation channels in lung liquid homeostasis in sheep
59. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo
60. Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema
61. Terbutaline stimulates alveolar fluid resorption in hyperoxic lung injury
62. Biophysical properties and molecular characterization of amiloride- sensitive sodium channels in A549 cells
63. Ventilator-associated lung injury decreases lung ability to clear edema in rats
64. Lung fluid transport in aquaporin-5 knockout mice
65. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia
66. Transepithelial transport by pulmonary alveolar type II cells in primary culture
67. Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells
68. Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties, and physiological significance
69. Alveolar epithelial fluid transport: Basic mechanisms and clinical relevance
70. Salt and water transport across alveolar and distal airway epithelia in the adult lung
71. Oxidant-mediated lung injury in the acute respiratory distress syndrome
72. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans
73. Direct regulation of the Na, K pump by signal transduction mechanisms
74. Impact of beta-adrenergic agonist on Na+ channel and Na+-K+-ATPase expression in alveolar type II cells
75. Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock
76. A novel alveolar type I cell-specific biochemical marker of human acute lung injury
77. Alveolar liquid clearance in the anesthetized ventilated guinea pig
78. Expression of the epithelial Na+ channel in the developing rat lung
79. Amiloride impairs lung water clearance in newborn guinea pigs
80. Lung liquid clearance and Na, K-ATPase during acute hyperoxia and recovery in rats
81. Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells
82. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats
83. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats
84. Role of nitric oxide in downregulating alveolar fluid clearance by a NFKB mechanisms in rats after hemorragic shock
85. Biological markers of acute lung injury: Prognostic and pathogenetic significance
86. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats
87. Resistance of the alveolar epithelium to injury from septic shock in sheep
88. Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells
89. Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line
90. O2-induced ENaC expression is associated with NF-kappaB activation and blocked by superoxide scavenger
91. Activation of the epithelial Na+ channel (ENaC) requires CFTR C1- channel function
92. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism
93. Chronic regulation of transepithelial Na+ transport by the rate of apical Na+ entry
94. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs
95. Alveolar fluid clearance in the resected human lung
96. Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs
97. Denopamine, a beta (1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs
98. Modulation of lung liquid clearance by isoproterenol in rat lungs
99. Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia
100. Beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury
101. Dopamine restores lung ability to clear edema in rats exposed to hyperoxia
102. Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans
103. High-altitude exposure impairs the alveolar transepithelial sodium transport in humans
104. Impairment of amiloride-sensitive sodium transport in individuals susceptible to high altitude pulmonary edema
105. Prevention of high-altitude pulmonary edema by beta-adrenergic stimulation of the alveolar transepithelial sodium transport
106. High-altitude pulmonary edema: From exaggerated pulmonary hypertension to a defect in transepithelial sodium transport
107. Cytochemical localization of Na+-K+-ATPase in rat type II pneumocytes
108. Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na (+) channel to the cell surface
109. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: Studies in transgenic aquaporin null mice
110. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method
111. Pulmonary edema
112. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
113. Pretreatment with cationic lipid-mediated transfer of the Na+K+-ATPase pump in a mouse model in vivo augments resolution of high permeability pulmonary oedema
114. CFTR as a cAMP-dependent regulator of sodium channels
115. Impairment of transalveolar fluid transport and lung Na (+)-K (+)-ATPase function by hypoxia in rats
116. Effects of intraalveolar oxygen concentration on alveolar fluid absorption and metabolism in isolated rat lungs
117. Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel
118. Mechanisms of lung liquid clearance during hyperoxia in isolated rat lungs
119. Epidermal growth factor increases lung liquid clearance in rat lungs
120. Lung epithelial Na channel subunits are differentially regulated during development and by steroids
121. Dobutamine increases alveolar liquid clearance in ventilated rats by beta- 2 receptor stimulation
122. Insulin-activated amiloride-blockable nonselective cation and Na+ channels in the fetal distal lung epithelium
123. Hypoxia reduces airway epithelial sodium transport in rats
124. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance
125. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema
126. Role of aquaporin water channels in kidney and lung
127. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice
128. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy
129. Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms
130. Elevated levels of markers of apoptosis in the biological fluids of patients with early acute lung injury
131. The acute respiratory distress syndrome
132. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
133. Mechanical stretching of alveolar epithelial cells increases Na (+)-K (+)- ATPase activity
134. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
135. Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung
136. Keratinocyte growth factor reduces lung damage due to acid instillation in rats
137. Keratinocyte growth factor ameliorates radiation- and bleomycine induced lung injury and mortality
138. Mechanisms and sequelae of increased alveolar fluid clearance in hyperoxic rats
139. Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats
140. Increase of lung sodium-potassium-ATPase activity during recovery from high-permeability pulmonary edema