Association mapping: Where we've been, where we're going

Expert Review of Molecular Diagnostics

Volumn 1, Issue 3, 2001, Pages 334-342

  Nielsen, Dahlia M ^a   Zaykin, Dmitri ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Association mapping; Case control; Genetic mapping; Linkage disequilibruim; Marker phenotype association; Transmission disequilibruim

Indexed keywords

GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MAPPING; GENETIC ASSOCIATION; HAPLOTYPE; LINKAGE ANALYSIS; MARKER GENE; PHENOTYPE; REVIEW;

EID: 0035557649     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737159.1.3.334     Document Type: Review

References (65)

1. The evolutionary dynamics of complex polymorphisms
2. Linkage disequilibrium measures for fine-scale mapping
3. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region
4. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
5. Variances and covariances of squared linkage disequibria in finite populations
6. Maximum likelihood estimation of gene location by linkage disequibrium
7. Estimation of linkage disequilibrium in randomly mating populations
8. Linkage disequilibrium measures for fine-scale mapping: A comparison
9. The optimal measure of allelic association
10. A classical setting for associations between markers and loci affecting quantitative traits
11. Association studies under general disease models
12. The use of measured genotype information in the analysis of quantitative phenotypes in man
13. Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans
14. Transmission-disequilibrium tests for quantitative traits
15. The TDT and other family-based tests for linkage disequilibrium and association
16. Tests for linkage and association in nuclear families
17. General score tests for associations of genetic markers with disease using cases and their parents
18. Likelihoods and TDT for the case-parents design
19. A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
20. Genetic association mapping based on discordant sib pairs, the discordant alleles test (DAT)
21. Use of siblings as controls in case-control association studies
22. A comparative study of sibship tests for linkage and/or association
23. A discordantsibship test for disequilibrium and linkage: No need for parental data
24. A note on the application of the transmission disequilibrium test when a parent is missing
25. The transmission/disequilibrium test and parental-genotype reconstruction: The reconstruction-combined transmission/disequilibrium test
26. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission
27. A test for linkage and association in general pedigrees: The pedigree disequilibrium test
28. A transmission disequilibrium test for quantitative trait loci
29. A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression
30. Removing the sampling restrictions from family-based tests of association for a quantitative trait locus
31. A general test of association for quantitative traits in nuclear families
32. Sibling-based tests of linkage and association for quantitative traits
33. Genomic control for association studies
34. Tests for linear trends in proportions and frequencies
35. Inference of population structure using mulitlocus genotype data
36. Association mapping in structured populations
37. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
38. A simple sequentially rejective multiple test procedure
39. A sharper bonferroni procedure for multiple tests of significance
40. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
41. Multiple tests for genetic effects in association studies
42. Controlling the false discovery rate - A practical and powerful approach to multiple testing
43. A new approach to the problem of multiple comparisons in the genetic dissection of complex traits
44. False discoveries in genome scanning
45. An additive method for combining probability values from independent experiments
46. An improved Bonferroni procedure for multiple tests of significance
47. Truncated product method for combining p-values
48. A consensus combined p-value and the family-wide significance of component tests
49. On closed testing procedures with special reference to ordered analysis of variance
50. A comprehensive analysis of complex traits in problem 2A
51. Regional inference with averaged p-values increases the power to detect linkage
52. True and false positive peaks in genomewide scans: Applications of lengthbiased sampling to genome mapping
53. Is peak height sufficient?
54. Complex promoter and coding region b2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
55. Promoter haplotype combinations of the platelet-derived growth factor a-receptor gene predispose to human neural tube defects
56. Haplotypes vs single marker linkage disequilibrium tests': What do we gain?
57. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
58. Issues concerning association studies for fine mapping a susceptibility gene for a complex disease
59. Maximum likelihood estimation of molecular haplotype frequencies in a diploid population
60. Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data
61. A new statistical method for haplotype reconstruction from population data
62. How many diseases does it take to map a gene with SNPs?