Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results

Nature Genetics

Volumn 11, Issue 3, 1995, Pages 241-247

  Lander, Eric ^a,b   Kruglyak, Leonid ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE MAPPING; GENETIC LINKAGE; HUMAN; INHERITANCE; INSULIN DEPENDENT DIABETES MELLITUS; MODEL; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REVIEW; SCHIZOPHRENIA; STANDARD; STATISTICAL ANALYSIS;

GENETICS; GENOME; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; RESEARCH DESIGN; STATISTICS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028877463     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1195-241     Document Type: Article

References (38)

1. Botstein, D., White, D.L., Skolnick, M. & Davis, R.W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. hum. Genet. 32, 314-331 (1980).
2. Baron, M. et al. Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326, 289-292 (1987).
3. Egeland, J.A. et al. Bipolar affective disorders linked to DNA markers on chromosome 11.Nature 325, 783-787 (1987).
4. Kelsoe, J.R. et al. Re-evaluation of the linkage relationship between chromosome 11 p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238-243 (1989).
5. Sherrington, R. et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164-167 (1988).
6. Kennedy, J.L. et al. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167-170 (1988).
7. Baron, M. et al. Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genet. 3, 49-55 (1993).
8. Lander, E.S. & Botstein, D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199 (1989).
9. Feingold, E., Brown, P.O. & Siegmund, D. Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. Am. J. hum. Genet. 53, 234-251 (1993).
10. Chotai, J. On the lod score method in linkage analysis. Ann. hum. Genet. 48, 359-378 (1984).
11. Elston, R.C. Designs for the global search of the human genome by linkage analysis. InProceedings of the 16th international Biometrics conference 39-51 (Hamilton, New Zealand, 1992).
12. Brown, D.L., Gorin, M.B. & Weeks, D.E. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis. Am. J. hum. Genet. 54, 544-652 (1994).
13. McKusick, V.A. & Edwards, J.H. Unassigned syntenic groups and theoretical considerations. Second international workshop on human gene mapping. Cytogenet Cell Genet. 14, 196-198 (1975).
14. Thomson, G. Identifying complex disease genes: progress and paradigms. Nature Genet.8, 108-110 (1994).
15. Suarez, B.K., Hampe, C.L. & Van Eeerdeweigh, P. Problems of replicating linkage claims in psychiatry. In Genetic approaches to mental disorders (eds. Gershon, E.S. & Cloninger, C.R.) 23-46 (American Psychiatric Association, Washington, DC, 1994).
16. Cox, D.R. & Hinkley, D.V. Theoretical Statistics(Chapman & Hall, 1974).
17. Spielman, R.S., McGinnis, R.E. & Ewens, W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellrtus (IDDM). Am. J. hum. Genet. 52, 506-516 (1993).
18. Bennett, S.T. et al. Susceptibility to human type 1 diabetes at IDDM2is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genet. 9, 284-92 (1995).
19. Copeman, J.B. et al. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nature Genet. 9, 80-85 (1995).
20. Ewens, W.J. & Spielman, R.S. The transmission/disequilibrium test: history, subdivision, and admixture. Am. J. hum. Genet. 57, 455-464 (1995).
21. Gough, S.C.L. et al. Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect? Hum. mol. Genet. 4, 1609-1612 (1995).
22. Thomson, G. Mapping disease genes: family-based association studies. Am. J. hum. Genet. 57, 487-498 (1995).
23. Terwilliger, J.D. & Ott, J. A multi-sample bootstrap approach to the estimation of maximized-over-models lod score distributions. Cytogenet. Cell Genet. 59, 142-144 (1992).
24. Davies, J.L. et al. A genome-wide search for human type 1 diabetes susceptibility genes.Nature 371, 130-136 (1994).
25. Hashimoto, L. et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11 q. Nature 371, 161-164 (1994).
26. Luo, D., Maclaren, N.K., Huang, H., Muir, A. & She, J. Intrafamilial and case-control association analyses of D2S152 in insulin-dependent diabetes mellitus. Autoimmunity(1995, in press).
27. Todd, J.A. Genetic analysis of type 1 diabetes using whole genome approaches. Proc. natn. Acad. Sci. U.S.A. 92, 8560-8565 (1995).
28. Luo, D. et al. Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am. J. hum. Genet. 57, 911-919 (1995).
29. Wang, S. et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature Genet. 10, 41-46 (1995).
30. Straub, R.E. et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet. 11, 287-293 (1995).
31. Moises, H.W. et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genet. 11, 321-324 (1995).
32. Schwab, S.G. et al. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet. 11, 325-327 (1995).
33. Gyapay, G. et al. The 1993-94 Genethon human genetic linkage map. Nature Genet. 7, 246-339 (1994).
34. Kruglyak, L. & Lander, E.S. Complete multipoint sib pair analysis of qualitative and quantitative traits. Am. J. hum. Genet. 57, 439-454 (1995).
35. Kruglyak, L. & Lander, E.S. A nonparametric approach for mapping quantitative traitloci.Genetics 139, 1421-1428 (1995).
36. Feingold, E. Markov processes for modeling and analyzing a new genetic mapping method.J. appl. Prob. 30, 766-779 (1993).
37. Feingold, E. R Asymptotic properties of affected-sib-pair linkage analysis. Am. J. hum. Genet. 52, 362-374 (1993).
38. Lander, E.S. & Schork, N.J. Genetic dissection of complex traits. Science 265, 2037-2048 (1994).