Regional inference with averaged P values increases the power to detect linkage

Genetic Epidemiology

Volumn 17, Issue 3, 1999, Pages 157-164

  Goldin, Lynn R ^a   Chase, Gary A ^b   Wilson, Alexander F ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HENRY FORD HEALTH SYSTEM   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Genome screening; Linkage detection; Regional inference; Sib pair tests

Indexed keywords

ARTICLE; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC MODEL; GENETIC SCREENING; HUMAN; QUANTITATIVE TRAIT;

BIAS (EPIDEMIOLOGY); CHROMOSOME MAPPING; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; EPIDEMIOLOGY, MOLECULAR; GENETIC PREDISPOSITION TO DISEASE; HUMAN GENOME PROJECT; HUMANS; REPRODUCIBILITY OF RESULTS;

EID: 0032819972     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1999)17:3<157::AID-GEPI1>3.0.CO;2-P     Document Type: Article

References (12)

1. Berrettini WH, Ferraro TN, Goldin LR, Detera-Wadleigh SD, Choi H, Guroff JJ, Kazuba DM, Nurnberger JI Jr, Hsieh WT, Hoehe MR, Gershon ES. 1997. A linkage study of bipolar illness. Arch Gen Psychiatry 54:27-35.
2. Goldgar DE. 1990. Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967.
3. Goldin LR, Chase GA. 1997. Improvement of the power to detect complex disease genes by regional inference procedures. Genet Epidemiol 14:785-789.
4. Goldin LR, Chase GA, King TM, Badner JA, Gershon ES. 1995. Use of exact and adjusted liability scores to detect genes affecting common traits. Genet Epidemiol 12:765-769.
5. Haseman JK, Elston RC. 1972.. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
6. Hauser ER, Boehnke M, Guo S-W, Risch N. 1996. Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol 13:117-138.
7. Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247.
8. MacCluer JW, Blangero J, Dyer TD, Speer MC. 1997. GAW10: Simulated family data for a common oligogenic disease with quantitative risk factors. Genet Epidemiol 14:737-742.
9. SAGE. 1994. Statistical analysis for genetic epidemiology, release 2.2. Computer program package available from the Department of Epidemiology and Biostatistics. Cleveland: Case Western Reserve University.
10. Siegmund KD, Todorov AA, Rao DC, Borecki IB. 1997. The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data. Genet Epidemiol 14:1047-1052.
11. Terwilliger JD, Shannon WD, Lathrop GM, Nolan JP, Goldin LR, Chase GA, Weeks D. 1997. True and false positive peaks in genome-wide scans: applications of length-biased sampling to linkage mapping. Am J Hum Genet 61:430-438.
12. Wilson AF, Bailey-Wilson JE, Pugh EW, Sorant AJM. 1996. The genometric analysis simulation program (GASP): a software tool for testing and investigating methods in statistical genetics. Am J Hum Genet 59:A193.