Haplotypes vs single marker linkage disequilibrium tests: What do we gain?

European Journal of Human Genetics

Volumn 9, Issue 4, 2001, Pages 291-300

  Akey, J ^a   Jin, L ^a   Xiong, M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Complex disease; Haplotypes; Linkage disequilibrium; Power

Indexed keywords

ARTICLE; CALCULATION; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENETIC DISTANCE; GENETIC MARKER; HAPLOTYPE; HEMOCHROMATOSIS; INHERITANCE; POPULATION GENETIC PARAMETERS; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

GENETIC DISEASES, INBORN; GENETIC MARKERS; GENETIC SCREENING; GENETICS, POPULATION; HAPLOTYPES; HEMOCHROMATOSIS; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; MODELS, STATISTICAL;

EID: 0035058585     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200619     Document Type: Article

References (28)

1. The future of genetic studies of complex human diseases
2. Genomewide transmission/disequilibrium testing-consideration of the genotype relative risks at disease loci
3. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
4. Estimating multilocus linkage disequilibria
5. Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations
6. The trimmed-haplotype test for linkage disequilibrium
7. Coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms
8. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
9. SNPing away at complex diseases
10. Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: An initial screen for bipolar disorder loci on chromosome 18
11. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
12. Linkage disequilibrium mapping of complex disease: Fantasy or reality?
13. Genome screens using linkage disequilibrium tests: Optimal marker-characteristics and feasibility
14. Multipoint linkage disequilibrium mapping with particular reference to the African-American population
15. Fine-Scale genetic mapping based on linkage disequilibrium: Theory and application
16. Haemochromatosis and HLA-H
17. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping
18. Data mining applied to linkage disequilibrium mapping
19. Tests and estimates of allelic association in complex inheritance
20. Use of unlinked genetic markers to detect population stratification in association studies
21. Transmission/disequilibrium tests for extended marker haplotypes
22. The gene responsible for a severe form of peripheral neuropathy and agenesis of the corpus callosum maps to chromosome 15q
23. Genetic analysis of idiopathnic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population
24. High-resolution linkage disequilibrium mapping of the cartilage-hair hypoplasia gene
25. Parental genotype reconstruction: Applications of haplotype relative risk to incomplete parental data
26. Direct haplotyping of kilobase-size DNA using carbon nanotube probes
27. A novel method for determining linkage between DNA sequences: Hybridization to paired probe arrays