Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5004-5010

  Magnus, T ^a   Chan, A ^a   Grauer, O ^a   Toyka, K V ^a   Gold, R ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METHYLPREDNISOLONE; MYELIN BASIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; ASSAY; AUTOIMMUNE DISEASE; CELL CONTACT; CELL SURFACE; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; GENE EXPRESSION; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MICROGLIA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

EID: 0035500299     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5004     Document Type: Article

References (59)

1. T-cell apoptosis in autoimmune diseases: Termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms
2. T-cell apoptosis in inflammatory brain lesions: Destruction of T cells does not depend on antigen recognition
3. Apoptosis in the nervous system in experimental allergic encephalomyelitis
4. Apoptosis of T lymphocytes in acute disseminated encephalomyelitis
5. Impairment of function in aging neutrophils is associated with apoptosis
6. Induction and activation of tissue transglutaminase during programmed cell death
7. Transglutaminase induction by various cell death and apoptosis pathways
8. Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes
9. Apoptosis: The importance of being eaten
10. Biology of inflammation: Chemical mediators and cellular injury
11. Tissue injury in inflammation: Oxidants, proteinases and cationic proteins
12. Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: A mechanism for removal of apoptotic cells in the inflamed nervous system
13. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-Ø PGE2, and PAF
14. Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis: Mediation by ανβ 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response
15. Immunosuppressive effects of apoptotic cells
16. Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes
17. Characterization of ameboid microglia isolated from developing mammalian brain
18. Production of nitrite by neonatal rat microglial cells/brain macrophages
19. Plasma membrane phospholipid asymmetry precedes DNA fragmentation in different apoptotic cell models
20. Usage of Vβ3.3 T-cell receptor by myelin basic proteinspecific encephalitogenic T-cell lines in the Lewis rat
21. Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
22. Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: Mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition mechanism that is uncoupled from chemokine secretion
23. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
24. Macrophage recognition of senescent neutrophils
25. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism
26. Macrophage phagocytosis of aging neutrophils in inflammation: Programmed cell death in the neutrophil leads to its recognition by macrophages
27. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
28. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death: A model for T-cell apoptosis in vivo
29. + encephalitogenic T cells
30. TGF-β induces the expression of FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia
31. Microglia induce CD4 T lymphocyte final effector function and death
32. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
33. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques
34. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells
35. Mature microglia resemble immature antigen-presenting cells
36. Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation
37. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
38. + T cells are not essential for induction and course of disease
39. Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo
40. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
41. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
42. Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation
43. Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4) IL-10, IL-II and transforming growth factor-β1 (TGF-βI) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia
44. Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microgIia: Up-regulation by interferon-γ and lipopolysaccharide and down-regulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents
45. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-β in macrophages that have ingested apoptotic cells
46. A receptor for phosphatidylserine-specific clearance of apoptotic cells
47. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
48. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
49. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
50. Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes
51. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
52. Activation of adult human derived microglia by myelin phagocytosis in vitro
53. Experimental autoimmune encephalomyelitis: The antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system
54. Microglia: Intrinsic immunoeffector cell of the brain
55. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive
56. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions
57. Inflammatory cells, microglia and MHC class II antigen-positive cells in the spinal cord of Lewis rats with acute and chronic relapsing experimental autoimmune encephatomyelitis
58. Brain-immune connection: Immunoregulatory properties of CNS-resident cells
59. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts