Usage of Vβ3.3 T-cell receptor by myelin basic protein-specific encephalitogenic T-cell lines in the Lewis rat

Journal of Neuroscience Research

Volumn 58, Issue 2, 1999, Pages 214-225

  Chan, Andrew ^a   Gold, Ralf ^a,d   Giegerich, Gerhard ^a,b   Herrmann, Thomas ^a   Jung, Stefan ^a   Toyka, Klaus V ^a   Hartung, Hans Peter ^a,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Autoimmunity; Multiple sclerosis; T cell receptor variable region

Indexed keywords

AUTOANTIGEN; MONOCLONAL ANTIBODY; MYELIN BASIC PROTEIN; PROTEIN SUBUNIT; T LYMPHOCYTE RECEPTOR BETA CHAIN; EPITOPE; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HYBRID CELL; IMMUNOCYTOCHEMISTRY; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; ANIMAL; CELL LINE; CYTOLOGY; FEMALE; IMMUNOHISTOCHEMISTRY; LEWIS RAT; LYMPH NODE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNODOMINANT EPITOPES; IMMUNOHISTOCHEMISTRY; LYMPH NODES; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0033568917     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991015)58:2<214::AID-JNR2>3.0.CO;2-6     Document Type: Article

References (38)

1. Ben-Nun A, Cohen IR. 1981. Vaccination against autoimmune encephalomyelitis (EAE): attenuated autoimmune T lymphoctes confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur J Immunol 11:949-952.
2. Burns FR, Li X, Shen N, Offner H, Chou YK, Vandenbark AA, Heber-Katz E. 1989. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 169:27-39.
3. Chluba J, Steeg C, Becker A, Wekerle H, Eppplen JT. 1989. T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol 19:279-284.
4. 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest 63:162-170.
5. Eylar EH, Kniskern PJ, Jackson JJ. 1979. Myelin basic proteins. Methods Enzymol 31:323-341.
6. Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. 1996. An αβ Tcell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science 274:209-219.
7. Gold DP, Offner H, Sun D, Wiley S, Vandenbark AA, Wilson DB. 1991. Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med 174:1467-1476.
8. Gold DP, Smith RA, Golding AB, Morgan EE, Dafashy T, Nelson J. 1997. Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRVβ6 CDR2 peptide. J Neuroimmunol 76:29-38.
9. Gold R, Giegerich G, Hartung H-P, Toyka KV. 1995. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR β-chain-variable region Vβ8.2-positive T cells are not essential for induction and course of disease. Proc Natl Acad Sci USA 92:5850-5854.
10. Hafler DA, Saadeh MG, Kuchroo VK, Milford E, Steinman L. 1996. TCR usage in human and experimental demyelinating disease. Immunol Today 17:152-159.
11. Hohlfeld R. 1997. Biotechnological agents for the immunotherapy of multiple sclerosis. Brain 120:865-916.
12. Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668-670.
13. Hünig T, Wallny H-J, Hartley JK, Lawetzky A, Tiefenthaler G. 1989. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J Exp Med 169:73-86.
14. Imrich H, Kugler C, Torres-Nagel N, Dörries R, Hünig T. 1995. Prevention and treatment of Lewis rat experimental allergic encephalomyelitis with a monoclonal antibody to the T cell receptor V́8.2 segment. Eur J Immunol 25:1960-1964.
15. Jung S, Krämer S, Schluesener HJ, Hünig T, Toyka K, Hartung HP. 1992. Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-α/β. J Immunol 12:3768-3775.
16. Karin N, Szafer F, Mitchell D, Gold DP, Steinman L. 1993. Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J Immunol 150:4116-4124.
17. Kumar V, Tabibiazar R, Geysen HM, Sercarz E. 1995. Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis. J Immunol 154:1941-1950.
18. Liblau R, Tisch R, Bercovici N, McDevitt HO. 1997. Systemic antigen in the treatment of T-cell-mediated autoimmune diseases. Immunol Today 12:599-604.
19. Martin R, McFarland HF, McFarlin DE. 1992. Immunological aspects of demyelinating diseases. Annu Rev Immunol 10:153-187.
20. Miltenyi S, Müller W, Eilchel W, Radbruch A. 1990. High gradient magnetic cell separation with MACS. Cytometry 11:231-238.
21. Mor F, Cohen IR. 1993. Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J Clin Invest 92:2199-2206.
22. Mor F, Kantorowitz M, Cohen IR. 1996. The dominant and the cryptic T cell repertoire to myelin basic protein in the Lewis rat. J Neurosci Res 45:670-679.
23. Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397-405.
24. Offner H, Hashim GA, Vandenbark AA. 1991. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251:430-432.
25. Offner H, Buenafe AC, Vainiene M, Celnik B, Weinberg AD, Gold DP, Hashim G, Vandenbark AA. 1993. Where, when, and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J Immunol 151:506-517.
26. Rook GAW, Hernandez-Pando R, Lightman SL. 1994. Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance. Immunol Today 15:301-303.
27. Smith LR, Kono DH, Kammuller ME, Balderas RS, Theofilopoulos AN. 1992. Vβ repertoire in rats and implications for endogenous superantigens. Eur J Immunol 22:641-645.
28. Stienekemeier M, Herrmann T, Kruse N, Weishaupt A, Weilbach FX, Giegerich G, Theofilopoulos A, Jung S, Gold R. 1999. Heterogeneity of T-cell receptor usage in experimental autoimmune neuritis in the Lewis rat. Brain 122:523-535.
29. Sun D, Le J, Coleclough C. 1993. Diverse T cell receptor β chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein. Eur J Immunol 23:494-4948.
30. Sun D, Hu X-Z. Le J, Swanborg RH. 1994. Characterization of brain-isolated rat encephalitogenic T cell lines. Eur J Immunol 24:1359-1364.
31. Torres-Nagel NE, Gold DP, Hünig T. 1993. Identification of rat Tcrb-V8.2, 8.5, and 10 gene products by monoclonal antibodies. Immunogenetics 37:305-308.
32. Tsuchida M, Matsumoto Y, Hirahara H, Hanawa H, Tomiyama K, Abo T. 1993. Preferential distribution of Vβ8.2-positive T cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis. Eur J Immunol 23: 2399-2406.
33. Vandenbaark AA, Hashim G, Offner H. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541-544.
34. Vandenbark AA, Chou YK, Whitham R, Mass M, Buenafe A, Liefeld D. 1996. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nature Med 2:1109-1115.
35. Weishaupt A, Gold R, Gaupp S, Giegerich G, Hartung H-P, Toyka KV. 1997. Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc Natl Acad Sci USA 94:1338-1343.
36. Wilson DB, Steinman L, Gold DP. 1993. The V-region disease hypothesis: new evidence suggests it is probably wrong. Immunol Today 14:376-382.
37. Zettl UK, Gold R, Toyka KV, Hartung H-P. 1995. Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the lewis rat. J Neuropathol Exp Neurol 54:540-547.
38. Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender A, Giegerich G, de Waal Malefyt R, Wekerle H, Hohlfeld R. 1998. Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis. Brain 121:1395-1407.