Inhibition of histone deacetylase activity causes cell type-specific induction of the PDGF-B promoter only in the absence of activation by its enhancer

Experimental Cell Research

Volumn 270, Issue 2, 2001, Pages 188-198

  Ullerås, Erik ^a   Miller, Stephen J ^a   Adam, Gail I R ^a,b   Kanduri, Chandrasekhar ^a   Wilcock, Arwen C ^a   Franklin, Gary C ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b Gemini Genomics   (Sweden)

^c BIACORE AB   (Sweden)

Author keywords

Acetylation; PDGF B; silencing; Trichostatin A

Indexed keywords

AZACITIDINE; HISTONE DEACETYLASE; PLATELET DERIVED GROWTH FACTOR B; TRICHOSTATIN A;

ACETYLATION; ARTICLE; CELL TYPE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MODULATION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

EID: 0035499918     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5338     Document Type: Article

References (45)

1. Chromatin and transcription
2. Transcriptional noise and the evolution of gene number
3. Competition between chromatin and transcription complex assembly regulates gene expression during early development
4. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
5. Histone acetylation and transcriptional regulatory mechanisms
6. Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
7. The human histone deacetylase family
8. Gene activation by histone and factor acetyltransferases
9. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo
10. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
11. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
12. Structure and function of a human TAFII250 double bromodomain module
13. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
14. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
15. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects
16. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
17. Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells
18. Modulating IGFBP-3 expression by trichostatin A: Potential therapeutic role in the treatment of hepatocellular carcinoma
19. Induction of gamma-globin by histone deacetylase inhibitors
20. Steroid receptor induction of gene transcription: A two-step model
21. Histone hyperacetylating agents stimulate promoter activity of human choline acetyltransferase gene in transfection experiment
22. Effects of histone deacetylase inhibitors on the Ah receptor gene promoter
23. Induction of reporter gene expression by inhibitors of histone deacetylase
24. Promoter specific sensitivity to inhibition of histone deacetylases: Implications for hormonal gene control, cellular differentiation and cancer
25. Mechanism of action and in vivo role of platelet-derived growth factor
26. Successive activation of the platelet-derived growth factor b receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma
27. Expression of the human PDGF-B gene is regulated by both positively and negatively acting cell type-specific regulatory elements located in the first intron
28. An Inr-containing sequence flanking the TATA box of the human c-sis (PDGF-B) proto-oncogene promoter functions in cis as a co-activator for its intronic enhancer
29. In vivo footprinting and functional analysis of the human c-sis/PDGF-B gene promoter provides evidence for two binding sites for transcriptional activators
30. Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: Uncoupling of IGF2 and H19 imprinting
31. Chromosomal mapping of core histone acetylation by immunoselection
32. Histone acetylation and gene induction in human cells
33. Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis
34. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites
35. Histone deacetylase 1 can repress transcription by binding to Spl
36. Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells
37. Roles of histone acetyltransferases and deacetylases in gene regulation
38. A novel type of regulatory element is required for promoter-specific activity of the PDGF-B intronic enhancer region
39. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
40. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2
41. Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine
42. Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene
43. Trichostatin A causes selective loss of DNA methylation in Neurospora
44. Minichromosome assembly of non-integrated plasmid DNA transfected into mammalian cells
45. Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate