UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin- kinase inhibitor in a p53-independent manner

Experimental Cell Research

Volumn 248, Issue 1, 1999, Pages 272-279

  Haapajärvi, Tarja ^a   Kivinen, Laura ^a   Heiskanen, Annamari ^a   Des Bordes, Charles ^a   Datto, Michael B ^b   Wang, Xiao Fan ^b   Laiho, Marikki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cell cycle; Cyclin kinase inhibitors; DNA damage; Posttranscriptional modification; Transcriptional regulation

Indexed keywords

PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FIBROBLAST; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET C RADIATION;

ANIMALIA; EUKARYOTA;

EID: 0033541394     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4403     Document Type: Article

References (50)

1. El-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Kinzler K. W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
2. Harper J. W., Adami G. R., Wei N., Keyomarsi K., Elledge S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
3. Gu Y., Turck C. W., Morgan D. O. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 366:1993;707-710.
4. Xiong Y., Hannon G. J., Zhang H., Casso D., Kobayashi R., Beach D. p21 is a universal inhibitor of cyclin kinases. Nature. 366:1993;701-704.
5. LaBaer J., Garrett M. D., Stevenson L. F., Slingerland J. M., Sandhu C., Chou H. S., Fattaey A., Harlow E. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:1997;847-862.
6. Flores-Rozas H., Kelman Z., Dean F. B., Pan Z. Q., Harper J. W., Elledge S. J., O'Donnell M., Hurwitz J. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc. Natl. Acad. Sci. USA. 91:1994;8655-8659.
7. Waga S., Hannon G. J., Beach D., Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 369:1994;574-578.
8. Kearsey J. M., Coates P. J., Prescott A. R., Warbrick E., Hall P. A. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene. 11:1995;1675-1683.
9. Chuang L. S.-H., Ian H.-I., Koh T.-W., Ng H.-H., Xu G., Li B. F. L. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science. 277:1997;1996-2000.
10. Shim J., Lee H., Park J., Kim H., Choi E.-J. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature. 381:1996;804-807.
11. Deng C., Zhang P., Harper J. W., Elledge S. J., Leder P. Mice lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:1995;675-684.
12. Brugarolas J., Chandrasekaran C., Gordon J. I., Beach D., Jacks T., Hannon G. J. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 377:1995;552-557.
13. Waldman T., Lengauer C., Kinzler K. W., Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature. 381:1996;713-716.
14. Brown J. P., Wei W., Sedivy J. M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:1997;831-834.
15. Dulic V., Stein G. H., Far D. F., Reed S. I. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol. Cell. Biol. 18:1998;546-557.
16. Lane D. P. p53, guardian of the genome. Nature. 358:1992;15-16.
17. Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
18. Polyak K., Xia Y., Zweier J. L., Kinzler K. W., Vogelstein B. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
19. Parker S. B., Eichele G., Zhang P., Rawls A., Sands A. T., Bradley A., Olson E. N., Harper J. W., Elledge S. J. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science. 267:1995;1024-1027.
20. Steinman R. A., Hoffman B., Iro A., Guillouf C., Liebermann D. A., El-Houseini M. E. Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene. 9:1994;3389-3396.
21. Macleod K. F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:1995;935-944.
22. Noda A., Ning Y., Venable S. F., Pereira-Smith O. M., Smith J. R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
23. El-Deiry W. S., Harper J. W., O'Connor P. M., Velculescu V. E., Canman C. E., Jackman J., Pietenpol J. A., Burrell M., Hill D. E., Wang Y., Wiman K. G., Mercer W. E., Kastan M. B., Kohn K. W., Elledge S. J., Kinzler K. W., Vogelstein B. WAF1/CIP1 in induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1994;1169-1174.
24. Datto M. B., Li Y., Panus J. F., Howe D. J., Xiong Y., Wang X.-F. Transforming growth factor-β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA. 92:1995;5545-5549.
25. Chin Y. E., Kitagawa M., Su W.-C. S., You Z.-H., Iwamoto Y., Fu X.-Y. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mediated by STAT1. Science. 272:1996;719-722.
26. Yan G. Z., Ziff E. B. Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J. Neurosci. 17:1997;6122-6132.
27. Zauberman A., Oren M., Zipori D. Involvement of p21(WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition. Oncogene. 15:1997;1705-1711.
28. Liu M., Lee M. H., Cohen M., Bommakanti M., Freedman L. P. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev. 10:1996;142-153.
29. Zeng Y.-X., El-Deiry W. S. Regulation of p21WAF1/CIP1 expression by p53-independent pathways. Oncogene. 12:1996;1557-1564.
30. Liu M., Iavarone A., Freedman L. P. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor: Correlation with retinoic induction of U937 cell differentiation. J. Biol. Chem. 271:1996;31723-31728.
31. Prowse D. M., Bolgan L., Molnár À., Dotto G. P. Involvement of the Sp3 transcription factor in induction of p21Cip1/Waf1 in keratinocyte differentiation. J. Biol. Chem. 272:1997;1308-1314.
32. Somasundaram K., Zhang H., Zeng Y.-X., Houvras Y., Peng Y., Zhang H., Wu G. S., Licht J. D., Weber B. L., El-Deiry W. S. Arrest of cell cycle by the tumour-suppressor BRCA-1 requires the CDK-inhibitor p21WAF1/Cip1. Nature. 389:1997;187-194.
33. Haapajärvi T., Kivinen L., Pitkänen K., Laiho M. Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation. Oncogene. 11:1995;151-159.
34. Kivinen L., Pitkänen K., Laiho M. Human retinoblastoma gene product prevents c-Ha-ras. Oncogene. 8:1993;2703-2711.
35. Datto M. B., Wang X.-F. Functional analysis of the transforming growth factor β responsive elements in the WAF1/Cip1/p21 promoter. J. Biol. Chem. 270:1995;28623-28628.
36. Haapajärvi T., Pitkänen K., Tsubari M., Laiho M. p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle. Mol. Cell. Biol. 17:1997;3074-3080.
37. Maltzman W., Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1984;1689-1694.
38. Hall P. A., McKee P. H., Menage H. D., Dover R., Lane D. P. High levels of p53 protein in UV-irradiated normal human skin. Oncogene. 8:1993;203-207.
39. Fritsche M., Haessler C., Brandner G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene. 8:1993;307-318.
40. Lu X., Lane D. P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell. 75:1993;765-778.
41. Zhan Q., Carrier F., Fornace A. J. J. Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol. Cell. Biol. 13:1993;4242-4250.
42. Petrocelli T., Poon R., Drucker D. J., Slingerland J. M., Rosen C. F. UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints. Oncogene. 12:1996;1387-1396.
43. Liu M., Pelling J. C. UV-B/A irradiation of mouse keratinocytes results in p53-mediated WAF1/CIP1 expression. Oncogene. 10:1995;1955-1960.
44. Pitkänen, K. Haapajärvi, T. Laiho, M. 1998, UV-induction of p53 activation and accumulation is dependent on cell cycle and pathways involving protein synthesis and phosphorylation, Oncogene, 16, 459, 469, 1998.
45. Loignon M., Fetni R., Gordon A. J., Drobetsky E. A. A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated skin fibroblasts. Cancer Res. 57:1997;3390-3394.
46. Owen G. I., Richer J. K., Tung L., Takimoto G., Horwitz K. B. Progesterone regulates transcription of the p21WAF1 cyclin-dependent kinase inhibitor through Sp1 and CBP/p300. J. Biol. Chem. 273:1998;10696-10701.
47. Biggs J. R., Kudlow J. E., Kraft A. S. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 cells. J. Biol. Chem. 271:1996;901-906.
48. Russo T., Zambrano N., Esposito F., Ammendola R., Cimino F., Fiscella M., Jackman J., O'Connor P. M., Anderson C. W., Appella E. A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J. Biol. Chem. 270:1995;29386-29391.
49. WAF1/CIP1/SDI1. Oncogene. 17:1998;781-787.
50. 1. Cell. 76:1994;1013-1023.