Double base lesions in DNA X-irradiated in the presence or absence of oxygen

Radiation Research

Volumn 153, Issue 4, 2000, Pages 442-446

  Box, Harold C ^a   Patrzyc, Helen B ^a   Dawidzik, Jean B ^a   Wallace, John C ^a   Freund, Harold G ^a   Iijima, Herbert ^a   Budzinski, Edwin E ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; ADENINE; CARBON; CYTOSINE; DNA; GUANINE; OLIGOMER; OXYGEN; THYMINE;

ARTICLE; CATTLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZING RADIATION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; X IRRADIATION;

BOS TAURUS;

EID: 0034126821     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2000)153[0442:DBLIDX]2.0.CO;2     Document Type: Article

References (14)

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2. H. C. Box, H. G. Freund, E. E. Budzinski, J. C. Wallace and A. E. Maccubbin, Free radical-induced double base lesions. Radiat. Res. 141, 91-94 (1995).
3. H. C. Box, E. E. Budzinski, J. B. Dawidzik, J. S. Gobey and H. G. Freund, Free radical-induced tandem base damage in DNA oligomers. Free Radic. Biol. Med. 23, 1021-1030 (1997).
4. H. C. Box, E. E. Budzinski, J. B. Dawidzik, J. C. Wallace and H. Iijima, Tandem lesions and other products in X-irradiated DNA oligomers. Radiat. Res. 149, 433-439 (1998).
5. E. Schroder, E. E. Budzinski, J. C. Wallace, J. D. Zimbrick and H. C. Box, Radiation chemistry of d(ApCpGpT). Int. J. Radiat. Biol. 68, 509-523 (1995).
6. C. von Sonntag, Topics in free radical-mediated DNA damage: purines and damage amplification-superoxic reactions - bleomycin, the incomplete radiomimetic. Int. J. Radiat. Biol. 66, 485-490 (1994).
7. E. E. Budzinski, J. B. Dawidzik, J. C. Wallace, H. G. Freund and H. C. Box, The radiation chemistry of d(CpGpTpA) in the presence of oxygen. Radiat. Res. 142, 107-109 (1995).
8. H. C. Box, E. E. Budzinski, J. B. Dawidzik, J. C. Wallace, M. S. Evans and J. S. Gobey, Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA). Radiat. Res. 145, 641-643 (1996).
9. E. E. Budzinski, J. B. Dawidzik, M. J. Rajecki, J. C. Wallace, E. A. Schroder and H. C. Box, Isolation and characterization of the products of anoxic irradiation of d(CpGpTpA). Int. J. Radiat. Biol. 71, 327-336 (1997).
10. J. M. Falcone and H. C. Box, Selective hydrolysis of damaged DNA by nuclease P1. Biochim. Biophys. Acta 1337, 267-275 (1997).
11. B. N. Ames, L. S. Gold and W. C. Willett, The causes and prevention of cancer Proc. Natl. Acad. Sci. USA 92, 5258-5265 (1995).
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14. A. Maccubbin, H. Iijima, N. Ersing, J. Dawidzik, H. Patrzyc, J. Wallace, H. Freund and H. Box, Double lesions are produced in DNA by free radicals. Arch. Biochem. Biophys., in press.