The mechanism of action of DNA photolyases

Current Opinion in Chemical Biology

Volumn 5, Issue 5, 2001, Pages 491-498

  Carell, Thomas ^a   Burgdorf, Lars T ^a   Kundu, Lal Mohan ^a   Cichon, Michaela ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CYCLOBUTANE; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; HISTIDINE; MUTAGENIC AGENT; OXETANE DERIVATIVE; PYRIMIDINE DIMER; QUERCETIN;

CELL DEATH; CHEMICAL REACTION; COENZYME; CRYSTAL STRUCTURE; DNA DAMAGE; ELECTRON TRANSPORT; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME MECHANISM; MUTAGENESIS; NONHUMAN; PHOTOACTIVATION; REVIEW; ULTRAVIOLET RADIATION;

CARCINOGENS; CATALYSIS; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; DNA; DNA DAMAGE; DNA REPAIR; HUMANS; LIGHT; MOLECULAR STRUCTURE; MUTATION; OXIDATION-REDUCTION; PYRIMIDINE DIMERS; SUBSTRATE SPECIFICITY;

EID: 0035478123     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00239-8     Document Type: Review

References (43)

1. Structure and function of DNA photolyase
2. Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog, and the DNA photolyase-blue light photoreceptor family
3. Unraveling the origin of the major mutations induced by ultraviolet light, the C-T transition at dTpdC sites. A DNA synthesis building block for the cis-syn cyclobutane dimer of dTpdU
4. Unraveling the molecular pathway from sunlight to skin cancer
5. Crystal structure of DNA photolyase from Escherichia coli
6. Crystal structure of DNA photolyase from Anacystis nidulans
7. Binding and catalytic properties of a Xenopus (6-4) photolyase
8. Reaction mechanism of (6-4) photolyase
9. A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4) photoproducts
10. On base flipping
11. How do DNA repair proteins locate damaged bases in the genome?
12. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
13. Evidence for dinucleotide flipping by DNA-photolyases
14. Direct visualization of dynamic protein DNA interactions with a dedicated atomic force microscope
15. DNA bending by photolyase in specific and non-specific complexes studied by atomic force microscopy
16. Determination of rates and yields of interchromophore (folate-flavin) energy transfer and intermolecular (flavin-DNA) electron transfer in Escherichia coli photolyase by time-resolved fluorescence and absorption spectroscopy
17. 2-T = T) in Anacystis nidulans photolyase
18. A model for the enzyme-substrate complex of DNA photolyase and photodamaged DNA
19. Theoretical study of electron transfer between the photolyase catalytic cofactor FADH- and DNA thymine dimer
20. Synthesis of flavin-containing model compounds for DNA photolyase mediated DNA repair
21. Investigation of flavin-containing DNA-repair model compounds
22. Repair of UV light induced DNA lesions: A comparative study with model compounds
23. Model studies of DNA photorepair: Energetic requirements for the radical anion mechanism determined by fluorescence quenching
24. DFT study of the [2+2] cycloreversion of uracil dimer anion radical: Waters matter
25. Flavin and deazaflavin containing model compounds mimic the energy-transfer step in type II DNA-photolyases
26. Efficient light-dependent DNA repair requires a large cofactor separation
27. From enzyme to molecular device. Exploring the interdependence of redox and molecular recognition
28. EPR detection of the transient tyrosyl radical in DNA photolyase from Anacystis nidulans
29. Intraprotein electron transfer between tyrosine and tryptophane in DNA photolyase from Anacystis nidulans
30. Intraprotein radical transfer during photoreactivation of DNA-photolyases
31. Active site of DNA photolyase: Tryptophan-306 is the intrinsic hydrogen atom donor essential for flavin radical photoreduction and DNA repair in vitro
32. Protein radicals in enzyme catalysis
33. DNA, sunlight and skin cancer
34. Characterization of a (6-4) photoproduct DNA photolyase
35. Quantum chemical study of the electron-transfer-catalyzed splitting of oxetane and azetidine intermediates proposed in the photoenzymatic repair of (6-4) photoproducts of DNA
36. Model studies of the (6-4) photo product DNA photolyase: Synthesis and photosensitized splitting of a thymine-5,6-oxetane
37. Model studies of the (6-4) photo product photolyase enzyme: Laser flash photolysis experiments confirm radical ion intermediates in the sensitized repair of thymine oxetane adducts
38. Photochemistry of the thio-analogue of the DNA (6-4) photoproduct Dewar valence isomer: Structure of a new photoproduct
39. Photoenzymatic repair of the DNA (6-4) photoproduct - A density functional theory and semiempirical study
40. New developments in the chemistry of N-acylimminium ions and related intermediates
41. Formation of C-C bonds by addition to imino groups
42. Role of two histidines in the (6-4) photolyase reaction
43. Substrate binding of DNA photolyase studied by electron paramagnetic resonance spectroscopy