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Volumn 121, Issue 32, 1999, Pages 7318-7329

Efficient light-dependent DNA repair requires a large cofactor separation

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DIMER; FLAVINE ADENINE NUCLEOTIDE; RIBOFLAVIN DERIVATIVE; TETRAHYDROFOLIC ACID DERIVATIVE;

EID: 0033581149     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990466l     Document Type: Article
Times cited : (24)

References (55)
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    • Begley, T. P. Acc. Chem. Res. 1994, 27, 394-401. Carell, T.; Epple, R. Eur. J. Org. Chem. 1998, 1245, 5-1258.
    • (1998) Eur. J. Org. Chem. , vol.1245 , pp. 5-1258
    • Carell, T.1    Epple, R.2
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    • (1995) Chimia , vol.49 , pp. 365-373
    • Carell, T.1
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    • Dissertation, Heidelberg
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    • (1993)
    • Petry, C.1
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    • Auflage ed.; Deutscher Verlag der Wissenschaften: Berlin
    • Becker, H. G. O. Einführung in die Photochemie, 3. Auflage ed.; Deutscher Verlag der Wissenschaften: Berlin, 1991.
    • (1991) Einführung in die Photochemie , vol.3
    • Becker, H.G.O.1
  • 48
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    • unpublished results. The deazaflavin is also able to perform an energy transfer to the oxidized flavin. This energy transfer was investigated by short-time laser fluorescence spectroscopy. The distances between the cofactors were estimated from the fluorescence lifetimes according to the Förster theory
    • Michel-Beyerle, M. E.; Carell, T., unpublished results. The deazaflavin is also able to perform an energy transfer to the oxidized flavin. This energy transfer was investigated by short-time laser fluorescence spectroscopy. The distances between the cofactors were estimated from the fluorescence lifetimes according to the Förster theory.
    • Michel-Beyerle, M.E.1    Carell, T.2
  • 55
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    • Park et al. proposed, for the folate-containing type-I photolyases, that the energy transfer within photolyases is not rate limiting. In this case, we would expect identical repair rates for all prepared model compounds, independent from the flavin-deazaflavin distance. This is clearly not observed. All compounds feature largely different repair efficiencies
    • Park et al. proposed, for the folate-containing type-I photolyases, that the energy transfer within photolyases is not rate limiting. In this case, we would expect identical repair rates for all prepared model compounds, independent from the flavin-deazaflavin distance. This is clearly not observed. All compounds feature largely different repair efficiencies.


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