A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells

Blood

Volumn 98, Issue 5, 2001, Pages 1561-1566

  Drbal, Karel ^a   Angelisová, Pavla ^a   Hilgert, Ivan ^a   Černý, Jan ^a   Novák, Petr ^a   Hořejší, Václav ^a,b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; INTEGRIN; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL ACTIVATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; LEUKOCYTE; LIGAND BINDING; MALE; MASS SPECTROMETRY; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROSTATECTOMY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; URINALYSIS;

EID: 0035469822     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.5.1561     Document Type: Article

References (43)

1. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997;89:3503-3521.
2. Hooper NM, Karran EH, Turner AJ. Membrane protein secretases. Biochem J. 1997;321:265-279.
3. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-314.
4. 2-integrins and their cellular ligands. Eur J Biochem. 1997;245:215-232.
5. 2 integrins in inflammation. In: Gallin JI, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 1999:537-568.
6. Harris ES, McIntyre TM, Prescott SM, Zimmerman GA. The leukocyte integrins. J Biol Chem. 2000;275:23409-23412.
7. Stewart M, Hogg N. Regulation of leukocyte integrin function: affinity vs. avidity. J Cell Biochem. 1996;61:554-561.
8. Bazzoni G, Hemler ME. Are changes in integrin affinity and conformation overemphasized Trends Biochem Sci. 1998;23:30-34.
9. Binnerts ME, van Kooyk Y. How LFA-1 binds to different ligands. Immunol Today. 1999;20:240-245.
10. Humphries MJ. Integrin cell adhesion receptors and the concept of agonism. Trends Pharmacol Sci. 2000;21:29-32.
11. Plow EF, Haas TA, Zhang L, Loftus J, Smith JW. Ligand binding to integrins. J Biol Chem. 2000;275:21785-21788.
12. Leitinger B, Hogg N. From crystal clear ligand binding to designer I domains. Nat Struct Biol. 2000;7:614-616.
13. van Kooyk Y, Figdor CG. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr Opin Cell Biol. 2000;12:542-547.
14. Bažil V, Štefanová I, Hilgert I, Krištofova H, Vaněk S, Hořejši V. Monoclonal antibodies against human leucocyte antigens, IV: antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein. Folia Biol (Praha). 1990;36:41-50.
15. Drbal K, Angelisova P, Černý J, et al. Human leukocytes contain a large pool of free forms of CD18. Biochem Biophys Res Commun. 2000;275:295-299.
16. Hogg N, McDowall A. CD18 Workshop Panel report. In: Kishimoto T, Kikutani H, von dem Borne AEGK, et al, eds. Leukocyte Typing VI. New York: Garland Publishing; 1997:355-357.
17. Schägger H, von Jagow G. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem. 1991;199:223-231.
18. Owen CA, Campbell EJ. The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol. 1999;65:137-150.
19. Vaday GG, Lider O. Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation. J Leukoc Biol. 2000;67:149-159.
20. Dunon D, Piali L, Imhof BA. To stick or not to stick: the new leukocyte homing paradigm. Curr Opin Cell Biol. 1996;8:714-723.
21. Schafffetter-Kochanek K, Lu H, Norman K, et al. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med. 1998;188:119-131.
22. Fodow SB, White EJ, Barlow SC, et al. Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice. J Clin Invest. 2000;106:1457-1466.
23. Oxvig C, Lu C, Springer TA. Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. Proc Natl Acad Sci U S A. 1999;96:2215-2220.
24. Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Computational design of an integrin I domain stabilized in the open high affinity conformation. Nat Struct Biol. 2000;7:674-678.
25. Xiong JP, Li R, Essafi M, Stehle T, Arnaout MA. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J Biol Chem. 2000;275:38762-38767.
26. Blobel CP. Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol. 2000;12:606-612.
27. Ugwu F, Van Hoef B, Bini A, Collen D, Lijnen HR. Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3). Biochemistry. 1998;37:7231-7236.
28. Murphy G, Gavrilovic J. Proteolysis and cell migration: creating a path? Curr Opin Cell Biol. 1999;11:614-621.
29. Heymans S, Luttun A, Nuyens D, et al. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med. 1999;5:1135-1142.
30. Yana I, Weiss SJ. Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell. 2000;11:2387-2401.
31. Raza SL, Nehring LC, Shapiro SD, Cornelius LA. Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases. J Biol Chem. 2000;275:41243-41250.
32. 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med. 1995;181:1381-1390.
33. 2) and modulates polymorphonuclear leukocyte adhesion. J Exp Med. 1996;184:1213-1223.
34. 2 integrins in vivo. J Exp Med. 1998;188:1029-1037.
35. Zang Q, Lu C, Huang C, Takagi J, Springer TA. The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 β subunit contacts the α subunit β-propeller domain near β-sheet 3. J Biol Chem. 2000;275:22202-22212.
36. 2+-dependent protease, calpain. J Cell Biol. 1998;140:699-707.
37. 2, CD11a/CD18) heterodimer formation and ligand binding. FEBS Lett. 1998;440:414-418.
38. IIb subunit heavy chain. Involvement in the potentiation of platelet aggregation. J Biol Chem. 1997;272:11636-11647.
39. Youker KA, Beirne J, Lee J, Michael LH, Smith CW, Entman ML. Time-dependent loss of Mac-1 from infiltrating neutrophils in the reperfused myocardium. J Immunol. 2000;164:2752-2758.
40. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature. 1995;376:517-519.
41. Robinson MK, Andrew D, Rosen H, et al. Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events. J Immunol. 1992;148:1080-1085.
42. Petruzzelli L, Springer TA. CD18 cluster report. In: Schlossman SF, Boumsell L, Gilks W, et al., eds. Leukocyte Typing V. Oxford, United Kingdom: Oxford University Press; 1995:1592-1593.
43. Leitinger B, Hogg N. Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1. Mol Biol Cell. 2000;11:677-690.