Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice

Journal of Clinical Investigation

Volumn 106, Issue 12, 2000, Pages 1457-1466

  Forlow, S B ^a   White, E J ^a   Barlow, S C ^a   Feldman, S H ^a   Lu, H ^a   Bagby, G J ^a   Beaudet, A L ^a   Bullard, D C ^a   Ley, K ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL VIABILITY; CONTROLLED STUDY; IMMUNE DEFICIENCY; IMMUNOREACTIVITY; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR RATE; SIGNAL TRANSDUCTION;

EID: 0034518433     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10555     Document Type: Article

References (44)

1. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
2. Selectins and their ligands: Current concepts and controversies
3. Spontaneous skin ulceration and defective T cell function in CD 18 null mice
4. A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo
5. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo
6. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neuttophil adhesion
7. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
8. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
9. Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins
10. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
11. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
12. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
13. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin
14. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation
15. LFA- 1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
16. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
17. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice
18. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1
19. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1
20. P-selectin/ICAM-1 double mutant mice: Acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli
21. Importance of E-selectin for firm leukocyte adhesion in vivo
22. Host defense against systemic infection with Streptococcus pneumoniae is impaired in E-, P-, and E-/P-selectin-deficient mice
23. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo
24. A versatile video image analysis system for microcirculatory research
25. Application of the 'two-slit' photometric technique to the measurement of microvascular volumetric flow rates
26. Concentration and velocity profiles of blood cells in the microcirculation
27. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo
28. IL-17 stimulates granulopoiesis in mice: Use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines
29. Xanthine oxidase and neutrophil infiltration in intestinal ischemia
30. Assessment of myeloperoxidase activity in whole rat kidney
31. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differenriation antigen (Gr-1) detects members of the Ly-6 family
32. Regulation of E-selectin, P-selectin, and intercellular adhesion molecule 1 expression in mouse cremaster muscle vasculature
33. Variation in the velocity, deformation, and adhesion energy density of leukocytes rolling within venules
34. Leukocyte rolling velocity and its relation to leukocyte-endothelium adhesion and cell deformability
35. Impairment of neutrophil emigration in CD18-null mice
36. Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD 18-deficient mice
37. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow
38. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
39. Targeted disruption of the murine VCAM1 gene: Essential role of VCAM-1 in chorioallantoic fusion and placentation
40. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
41. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
42. The granulocyte-macrophage regulators: Reappraisal by gene inactivation
43. Redistribution of red blood cell flow in microcirculatory networks by hemodilution
44. Pressure-flow relations in blood and lymph microcirculation