Therapeutic aspects of tolerance

Current Opinion in Pharmacology

Volumn 1, Issue 4, 2001, Pages 392-397

  Waldmann, Herman ^a   Cobbold, Stephen P ^a   Fairchild, Paul ^a   Adams, Elizabeth ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Dendritic cells; Immunology; Immunosuppression; Negative vaccination; Pharmacology; T cell regulation; Tolerance

Indexed keywords

MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL; DRUG EFFECT; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NEUTROPHIL CHEMOTAXIS; ORGAN TRANSPLANTATION; PASSIVE IMMUNIZATION; PHYSIOLOGY; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, SURFACE; CHEMOTAXIS, LEUKOCYTE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MATERNALLY-ACQUIRED; ORGAN TRANSPLANTATION; T-LYMPHOCYTES;

EID: 0035431763     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(01)00068-6     Document Type: Review

References (51)

1. Gallucci S., Matzinger P. Danger signals SOS to the immune system. Curr Opin Immunol. 13:2001;114-119. A very compact review on the factors that can activate the immune system so as to alert it to seemingly 'dangerous' antigens.
2. Aderem A., Ulevitch R.J. Toll-like receptors in the induction of the innate immune response. Nature. 406:2000;782-787.
3. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., Pulendran B., Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol. 18:2000;767-811.
4. Fairchild P.J., Waldmann H. Dendritic cells and prospects for transplantation tolerance. Curr Opin Immunol. 12:2000;528-535.
5. Thery C., Amigorena S. The cell biology of antigen presentation in dendritic cells. Curr Opin Immunol. 13:2001;45-51.
6. Lutz M.B., Suri R.M., Niimi M., Ogilvie A.L., Kukutsch N.A., Rossner S., Schuler G., Austyn J.M. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol. 30:2000;1813-1822.
7. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med. 192:2000;1213-1222.
8. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigenspecific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med. 193:2001;233-238. Worth a good discussion in a journal club!
9. Roncarolo M.G., Levings M.K., Traversari C. Differentiation of Tregulatory cells by immature dendritic cells. J Exp Med. 193:2001;F5-F10. An elegant discussion, which proposes a role for immature DCs in presentation of antigen to regulatory T cells.
10. Steinman R.M., Turley S., Mellman I., Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med. 191:2000;411-416.
11. Penna G., Adorini L. 1 alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol. 164:2000;2405-2411.
12. Piemonti L., Monti P., Sironi M., Fraticelli P., Leone B.E., Dal Cin E., Allavena P., Di Carlo V. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol. 164:2000;4443-4451.
13. + T-helper and a T-killer cell. Nature. 393:1998;474-477.
14. Bennett S.R., Carbone F.R., Karamalis F., Flavell R.A., Miller J.F., Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478-480.
15. Schoenberger S.P., Toes R.E., van der Voort E.I., Offringa R., Melief C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:1998;480-482.
16. Hall B.M. Mechanisms of induction of tolerance to organ allografts. Crit Rev Immunol. 20:2000;267-324. A very good evaluation of what is known about mechanisms that underlie tolerance to transplanted tissues, with a useful overview of the evolution of ideas on regulatory T cells in transplantation tolerance.
17. Waldmann H., Cobbold S. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu Rev Immunol. 16:1998;619-644.
18. Honey K., Cobbold S.P., Waldmann H. CD40 ligand blockade induces CD4 T cell tolerance and linked suppression. J Immunol. 163:1999;4805-4810. This paper reports the surprising observation that an antibody advertised as 'blocking' signal 2, also promotes tolerance maintained by regulatory T cells.
19. Durham M.M., Bingaman A.W., Adams A.B., Ha J., Waitze S.Y., Pearson T.C., Larsen C.P. Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol. 165:2000;1-4.
20. Wekerle T., Kurtz J., Ito H., Ronquillo J.V., Dong V., Zhao G., Shaffer J., Sayegh M.H., Sykes M. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med. 6:2000;464-469.
21. Chatenoud L., Primo J., Bach J.F. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol. 158:1997;2947-2954. The first demonstration that CD3 antibodies can reverse an autoimmune disease (diabetes) even at an advanced stage when endocrine tissue is still available to secrete insulin.
22. Li X.C., Wells A.D., Strom T.B., Turka L.A. The role of T cell apoptosis in transplantation tolerance. Curr Opin Immunol. 12:2000;522-527. The demonstration that certain agents that promote transplantation tolerance across major barriers do so through reducing alloreactive clone sizes through activation-induced cell death (AICD).
23. + T cells that enter the islets.
24. Waldmann H., Cobbold S.P. T-cell regulation and transplantation tolerance. Curr Opin Organ Transplant. 5:2000;83-89.
25. Zhai Y., Kupiec-Weglinski J.W. What is the role of regulatory T cells in transplantation tolerance? Curr Opin Immunol. 11:1999;497-503.
26. Graca L., Honey K., Adams E., Cobbold S.P., Waldmann H. Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol. 165:2000;4783-4876. The demonstration that CD40L (CD154) antibodies can bring about infectious tolerance with the same features as that evoked by CD4 antibodies.
27. Weiner H.L., Friedman A., Miller A., Khoury A.J., Al-Sabbagh A., Santos L., Sayegh M., Nussenblatt R.B., Trenthman D.B., Hafler D.L. Oral tolerance: immune mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 12:1994;809-837.
28. Mason D., Powrie F. Control of immune pathology by regulatory T cells. Curr Opin Immunol. 10:1998;649-655.
29. + thymocytes expressing L-selectin mediate 'active tolerance' in the nonobese diabetic mouse. J Immunol. 161:1998;2620-2628.
30. + T cells that can prevent autoimmune disease.
31. Shevach E.M. Regulatory T cells in autoimmunity. Anergic T cells actively repress T cell responses via the antigen-presenting cell. Annu Rev Immunol. 18:2000;423-449. It is very surprising how little data about T-cell regulation coming out of transplantation biology are discussed by this reviewer.
32. Maeda H., Fujimoto S., Greene M.I. Suppressor T-cells regulate the non-anergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor vβ 8.1 transgenic mice. Proc Natl Acad Sci USA. 97:2000;13257-13262.
33. Davies J.D., O'Connor E., Hall D., Krahl T., Trotter J., Sarvetnik N.J. CD4 and CD45RB low-density cells from untreated mice present acute allograft rejection. J Immunol. 163:1999;5353-5357.
34. Groux H., Powrie F. Regulatory T-cells and inflammatory bowel disease. Immunol Today. 20:1999;442-445.
35. Elias D., Meilin A., Ablamunits V., Birk O.S., Carmi P., Konen-Waisman S., Cohen I.R. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes. 46:1997;758-764.
36. Anderton S., Burkhart C., Metzler B., Wraith D. Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis. Immunol Rev. 169:1999;123-137. A fine review of the principles underlying peptide therapy in experimental encephalomyelitis and its relevance to multiple sclerosis.
37. Mocci S., Lafferty K., Howard M. The role of autoantigens in autoimmune disease. Curr Opin Immunol. 12:2000;725-730.
38. Harrison L.C., Hafler D.A. Antigen-specific therapy for autoimmune disease. Curr Opin Immunol. 12:2000;704-711.
39. Winer S., Gunaratnam L., Astsatourov I., Cheung R.K., Kubiak V., Karges W., Hammond-McKibben D., Gaedigk R., Graziano D., Trucco M., et al. Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes. J Immunol. 165:2000;4086-4094.
40. McFarland H.I., Lobito A.A., Johnson M.M., Palardy G.R., Christina S., Yee K., Jordan E.K., Frank J.A., Tresser N., Genain C.P., et al. Effective antigen-specific immunotherapy in the marmoset model of multiple sclerosis. J Immunol. 166:2001;2116-2121.
41. Selmaj K., Kowal C., Walczak A., Nowicka J., Raine C.S. Naked DNA vaccination differentially modulates autoimmune responses in experimental autoimmune encephalomyelitis. J Neuroimmunol. 111:2000;34-43.
42. Thomas J.M., Contreras J.L., Jiang Z.L., Eckhoff D.E., Wang P.X., Hubbard W.J., Lobashevsky A.L., Wang W., Asiedu C., Stavrou S., et al. Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deosyspergualin. Transplantation. 68:1999;1660-1673. An heroic demonstration that transplantation tolerance can be achieved in primates using, among others agents, those that can partially deplete T cells.
43. Knechtle S.J. Knowledge about transplantation tolerance gained in primates. Curr Opin Immunol. 12:2000;552-556. A good summary of the recent advances in strategies for transplantation tolerance in primates as models for humans.
44. Cho C.S., Fechner J.H. Jr, Knechtle S.J. T cell depletion as a means of achieving tolerance. Curr Opin Organ Transplant. 5:2000;96-102.
45. Kirk A.D., Burkly L.C., Batty D.S., Baumgartner R.E., Berning J.D., Buchanan K., Fechner J.H. Jr, Germond R.L., Patterson N.B. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med. 5:1999;686-693.
46. Waldmann H. Transplantation tolerance-where do we stand? Nat Med. 5:1999;1245-1248.
47. Calne R., Moffatt S.D., Friend P.J., Jamieson N.V., Bradley J.A., Hale G., Firth J., Bradley J., Smith K.G., Waldmann H. Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients. Transplantation. 68:1999;1613-1616. The description of 'prope tolerance' - a simple regimen where patients have low-dose steroid-free drug maintenance after a short pulse of the lymphocyte depleting antibody CAMPATH-1H.
48. Fairchild P.J., Brook F.A., Gardner R.L., Graça L., Strong V., Tone Y., Tone M., Nolan K.F., Waldmann H. Directed differentiation of dendritic cells from mouse embryonic stem cells. Curr Biol. 10:2000;1515-1518. The description of technology to grow large numbers of immature DCs from embryonic stem cells.
49. Hancock W.W., Gao W., Faia K.L., Csizmadia V. Chemokines and their receptors in allograft rejection. Curr Opin Immunol. 12:2000;511-516. An interesting account implicating chemokines as potential targets for tolerance-based intervention.
50. Mellor A.L., Munn D.H. Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol. 18:2000;367-391. A good review of the exciting discovery that tryptophan metabolism may be important in preventing the mother from rejecting the allogeneic foetus. There might be broader implications in the context of self tolerance and transplantion.
51. Hwu P., Du M.X., Lapointe R., Do M., Taylor M.W., Young H.A. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol. 164:2000;3596-3599. This paper investigates the question "could tryptophan metabolism be locally regulated by dendritic cells?".