Leptin expression in adipose tissue from obese humans: Depot-specific regulation by insulin and dexamethasone

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 3 38-3, 1998, Pages

  Russell, C D ^a   Petersen, R N ^a   Rao, S P ^a   Ricci, M R ^a   Prasad, A ^a   Zhang, Y ^c   Brolin, R E ^b   Fried, S K ^a,d  

^a the State University of New Jersey   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

Glucocorticoids; Obesity; Organ culture

Indexed keywords

DEXAMETHASONE; INSULIN; LEPTIN; MESSENGER RNA;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; FEMALE; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NORTHERN BLOTTING; OBESITY; ORGAN CULTURE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0031698546     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.3.e507     Document Type: Article

References (37)

1. Boden, G., X. Chen, J. W. Kolaczynski, and M. Polansky. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J. Clin. Invest. 100: 1107-1113, 1997.
2. Boden, G., X. Chen, M. Mozzoli, and I. Ryan. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81: 3419-3423, 1996.
3. Bronnegard, M., P. Arner, L. Hellstrom, G. Akner, and J.-A. Gustafsson. Glucocorticoid receptor messenger ribonucleic acid in different regions of human adipose tissue. Endocrinology 127: 1689-1696, 1990.
4. Cauter, E. V., E. T. Shapiro, H. Tillil, and K S. Polonsky. Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E467-E475, 1992.
5. Chomzczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
6. Cigolini, M., and U. Smith. Human adipose tissue in culture. VIII. Studies on the insulin-antagonistic effect of glucocorticoids. Metabolism 28: 502-510, 1979.
7. Considine, R. V., M. R. Nyce, J. W. Kolaczynski, P. L. Zhang, J. P. Ohannesian, J. H. J. Moore, J. W. Fox, and J. F. Caro. Dexamethasone stimulates leptin release from human adipocytes: unexpected inhibition by insulin. J. Cell. Biochem. 65: 254-258, 1997.
8. Considine, R. V., M. K. Sinha, M. L. Heiman, A. Kriauciunas, T. W. Stephens, M. R. Nyce, J. P. Ohannesian, C. Marco, L. J. McKee, T. L. Bauer, and J. F. Caro. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292-295, 1996.
9. Dagogo-Jack, S., G. Selke, A. K. Melson, and J. W. Newcomer. Robust leptin secretory responses to dexamethasone in obese subjects. J. Clin. Endocrinol. Metab. 82: 3230-3233, 1997.
10. De Vos, P., R. Saladin, J. Auwerx, and B. Staels. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem. 270: 15958-15961, 1995.
11. Fried, S. K., C. D. Russell, N. L. Grauso, and R. E. Brolin. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J. Clin. Invest. 92: 2191-2198, 1993.
12. 11a.Gong, D.-W., S. Bi, R. E. Pratley, and B. D. Weintraub. Genomic structure and promoter analysis of the human obese gene. J. Biol. Chem. 271: 3971-3974, 1996.
13. Hajduch, E., I. Hainault, C. Meunier, C. Jardel, B. Hainque, M. Guerre-Millo, and M. Lavau. Regulation of glucose transporters in cultured rat adipocytes: synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation. Endocrinology 126: 4782-4789, 1995.
14. Hardie, L. J., N. Guilhot, and P. Trayhurn. Regulation of leptin production in cultured mature white adipocytes. Horm. Metab. Res. 28: 685-689, 1996.
15. Hirsch, J., and E. Gallian. Methods for the determination of adipose cell size in man and animals. J. Lipid Res. 9: 110-119, 1968.
16. Klein, S., S. W. Coppack, V. Mohamed-Ali, and M. Landt. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45: 984-987, 1996.
17. Kolaczynski, J. W., M. R. Nyce, R. V. Considine, G. Boden, J. J. Nolan, R. Henry, S. R. Mudaliar, J. Olefsky, and J. F. Caro. Acute and chronic elevations of insulin on leptin production in humans. Studies in vivo and in vitro. Diabetes 45: 699-701, 1996.
18. Kolaczynski, J. W., R. V. Considine, J. Ohannesian, C. Marco, I. Opentanova, M. R. Nyce, M. Myint, and J. F. Caro. Responses of leptin to short-term fasting and refeeding in humans. Diabetes 45: 1511-1515, 1996.
19. Kolaczynski, J. W., B. J. Goldstein, and R. V. Considine. Dexamethasone, OB gene, and leptin in humans; effect of exogenous hyperinsulinemia. J. Clin. Endocrinol. Metab. 82: 3895-3897, 1997.
20. Kolaczynski, J., J. P. Ohannesian, R. B. Considine, C. C. Marco, and J. F. Caro. Response of leptin to short-term and prolonged overfeeding in humans. J. Clin. Endocrinol. Metab. 81: 4162-4165, 1996.
21. Larsson, H., and B. Ahren. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. J. Clin. Endocrinol. Metab. 81: 4428-4432, 1996.
22. Lonnqvist, F., P. Arner, L. Nordfors, and M. Schalling. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat. Med. 1: 950-956, 1995.
23. Maffei, M., J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, S. Ranganathan, P. A. Kern, and J. M. Friedman. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1: 1155-1161, 1995.
24. Marin, P., N. Darin, T. Amemiya, B. Andersson, S. Jern, and P. Bjorntorp. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 41: 882-886, 1992.
25. Masuzaki, H., Y. Ogawa, N. Isse, N. Satoh, T. Okazaki, M. Shigemoto, T. Kawda, and K. Nakao. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44: 855-858, 1996.
26. Miell, J. P., P. Englaro, and W. F. Blum. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm. Metab. Res. 28: 704-707, 1996.
27. Montague, C. T., J. B. Prins, L. Sanders, J. E. Digby, and S. O'Rahilly. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46: 342-347, 1997.
28. Ostlund, R. E. J., J. W. Yang, S. Klein, and R. Gingerich. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J. Clin. Endocrinol. Metab. 81: 3909-3913, 1996.
29. Papaspyrou-Rao, S., S. H. Schneider, R. N. Petersen, and S. K. Fried. Dexamethasone increases leptin expression in humans in vivo. J. Clin. Endocrinol. Metab. 82: 1635-1637, 1997.
30. Reul, B. A., L. N. Ongemba, A. M. Pettier, J. C. Henquin, and S. M. Brichard. Insulin and insulin-like growth factor I antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue. Biochem. J. 324: 605-610, 1997.
31. Schwartz, M. W. Evidence that plasma leptin and insulin levels are associated with body adiposity via different mechanisms. Diabetes Care 20: 1476-1481, 1997.
32. Sehgal, P. B., E. Derman, G. R. Molloy, I. Tamm, and J. E. Darnell. 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneous RNA chains in HeLa cells. Science 194: 431-433, 1976.
33. Smith, U. Studies of human adipose tissue in culture. II. Influences of insulin and medium glucose concentration on cellular metabolism. J. Clin. Invest. 53: 91-98, 1974.
34. Takahashi, M., T. Funahashi, I. Shimomura, K. Miyaoka, and Y. Matsuzawa. Plasma leptin levels and body fat distribution. Horm. Metab. Res. 28: 751-752, 1996.
35. Utriainen, T., R. Malmstrom, S. Makimattila, and H. Yki-Jarvinen. Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45: 1364-1366, 1996.
36. Wabitsch, M., P. B. Jensen, W. F. Blum, C. T. Chitofersen, P. Englaro, E. Heinze, W. Rascher, W. Teller, H. Tornqvist, and H. Hauner. Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45: 1435-1438, 1996.
37. Wahrenberg, H., F. Lonnqvist, and P. Arner. Mechanisms underlying regional differences in lipolysis in human adipose tissue. J. Clin. Invest. 84: 458-467, 1989.