-
1
-
-
0026316096
-
Growth Factors and Cancer
-
Aaronson, S. A. Growth Factors and Cancer. Science 1991,254, 1146-1152.
-
(1991)
Science
, vol.254
, pp. 1146-1152
-
-
Aaronson, S.A.1
-
2
-
-
0029020282
-
Protein Kinases 6. the Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification
-
Hanks, S. K.; Hunter, T. Protein Kinases 6. The Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification. FASEB J. 1995, 9, 576-96.
-
(1995)
FASEB J.
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
3
-
-
0033026444
-
Strategies Toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors
-
Traxler, P.; Furet, P. Strategies Toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors. Pharmacol Ther. 1999, 82, 195-206.
-
(1999)
Pharmacol Ther.
, vol.82
, pp. 195-206
-
-
Traxler, P.1
Furet, P.2
-
4
-
-
0033757709
-
Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Anticancer Therapy
-
Raymond, E.; Faivre, S.; Armand, J. P. Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Anticancer Therapy. Drugs 2000, 60, Suppl 1, 15-2.
-
(2000)
Drugs
, vol.60
, Issue.1 SUPPL.
, pp. 15-22
-
-
Raymond, E.1
Faivre, S.2
Armand, J.P.3
-
5
-
-
0024328467
-
Epidermal Growth Factor: The Receptor and its Function
-
Todderud, G.; Carpenter, G. Epidermal Growth Factor: The Receptor and its Function. Biofactors 1989,2, 1115.
-
(1989)
Biofactors
, vol.2
, pp. 1115
-
-
Todderud, G.1
Carpenter, G.2
-
6
-
-
0031684721
-
The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy
-
Ross, J. S.; Fletcher, J. A. The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy. Oncologist 1998, 3, 237-252.
-
(1998)
Oncologist
, vol.3
, pp. 237-252
-
-
Ross, J.S.1
Fletcher, J.A.2
-
7
-
-
0025874765
-
Epidermal Growth'Factor Receptor Expression as a Prognostic Indicator in Breast Cancer
-
Toi, M.; Osaki, A.; Yamada, H.; Toge, T. Epidermal Growth'Factor Receptor Expression as a Prognostic Indicator in Breast Cancer. Eur. J. Cancer 1991, 27, 97780.
-
(1991)
Eur. J. Cancer
, vol.27
, pp. 97780
-
-
Toi, M.1
Osaki, A.2
Yamada, H.3
Toge, T.4
-
8
-
-
0028266876
-
EOF Receptor Expression, Regulation, and Function in Breast Cancer
-
Chrysogelos, S.; Dickson, R. EOF Receptor Expression, Regulation, and Function in Breast Cancer. Breast CancerRes. Treat. 1994, 29, 29-40.
-
(1994)
Breast CancerRes. Treat.
, vol.29
, pp. 29-40
-
-
Chrysogelos, S.1
Dickson, R.2
-
9
-
-
0023850663
-
Characterization of Recombinant Human Epidermal Growth Factor Produced in Yeast
-
George-Nascimento, C.; Gyenes, A.; Halloran, S. M.; Merryweather, J.; Valenzuela, P.; Steimer, K. S.; Masiarz, F. R.; Randolph, A. Characterization of Recombinant Human Epidermal Growth Factor Produced in Yeast. Biochemistry 1988, 27, 797-802.
-
(1988)
Biochemistry
, vol.27
, pp. 797-802
-
-
George-Nascimento, C.1
Gyenes, A.2
Halloran, S.M.3
Merryweather, J.4
Valenzuela, P.5
Steimer, K.S.6
Masiarz, F.R.7
Randolph, A.8
-
10
-
-
0027360766
-
EGF Receptor in Neoplasia and Metastasis
-
Khazaie, K.; Schirrmacher, V.; Lichtner, R. EGF Receptor in Neoplasia and Metastasis. Cancer Metasis Rev. 1993, 12, 255-74.
-
(1993)
Cancer Metasis Rev.
, vol.12
, pp. 255-274
-
-
Khazaie, K.1
Schirrmacher, V.2
Lichtner, R.3
-
11
-
-
0028879656
-
Inhibitors of Protein Tyrosine Kinases
-
Fry, D. W.; Bridges, A. J. Inhibitors of Protein Tyrosine Kinases. Curr. Opin. Biotechnol. 1995, 6, 662-667.
-
(1995)
Curr. Opin. Biotechnol.
, vol.6
, pp. 662-667
-
-
Fry, D.W.1
Bridges, A.J.2
-
12
-
-
0030061424
-
Specific Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase by 4-anilinoquinazolines
-
Wakeling, A. E.; Barker, A. J.; Davies, D. H.; Brown, D. S.; Green, L. R.; Cartlidge, S. A.; Woodburn, J. R. Specific Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase by 4-anilinoquinazolines. Breast Cancer Research and Treatment 1996, 38, 67-73.
-
(1996)
Breast Cancer Research and Treatment
, vol.38
, pp. 67-73
-
-
Wakeling, A.E.1
Barker, A.J.2
Davies, D.H.3
Brown, D.S.4
Green, L.R.5
Cartlidge, S.A.6
Woodburn, J.R.7
-
13
-
-
0031887743
-
Protein Kinase Inhibitors: The Tyrosine-Specific Protein Kinases
-
Lawrence, D. S.; Niu, J. Protein Kinase Inhibitors: The Tyrosine-Specific Protein Kinases. Pharmacol. Ther. 1998,77, 81-114.
-
(1998)
Pharmacol. Ther.
, vol.77
, pp. 81-114
-
-
Lawrence, D.S.1
Niu, J.2
-
14
-
-
0029021518
-
Heterodimerization and Functional Interaction between EGF Receptor Family Members: A New Signaling Paradigm with Implications for Breast Cancer Research
-
Earp, H. S.; Dawson, T. L.; Li, X.; Yu, H. Heterodimerization and Functional Interaction between EGF Receptor Family Members: A New Signaling Paradigm with Implications for Breast Cancer Research. Breast Cancer Res. Treat. 1995,35, 115-132.
-
(1995)
Breast Cancer Res. Treat.
, vol.35
, pp. 115-132
-
-
Earp, H.S.1
Dawson, T.L.2
Li, X.3
Yu, H.4
-
15
-
-
0029067672
-
. An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-Defective Epidermal Growth Factor Receptors
-
Wright, J. D.; Reuter, C. W.; Weber, M. J. An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-Defective Epidermal Growth Factor Receptors. J. Biol. Chem. 1995, 270, 12085-93.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12085-12093
-
-
Wright, J.D.1
Reuter, C.W.2
Weber, M.J.3
-
16
-
-
0027935422
-
Epidermal Growth Factor Receptors in Human Breast Carcinoma Cells: A Potential Selective Target for Transforming Growth Factor AlphaPseudomonas Exotoxin 40 Fusion Protein
-
Arteaga, C. L.; Hurd, S. D.; Dugger, T. C.; Winnier, A. R.; Robertson, J. B. Epidermal Growth Factor Receptors in Human Breast Carcinoma Cells: A Potential Selective Target for Transforming Growth Factor AlphaPseudomonas Exotoxin 40 Fusion Protein. Cancer Res. 1994, 54, 4703-9.
-
(1994)
Cancer Res.
, vol.54
, pp. 4703-4709
-
-
Arteaga, C.L.1
Hurd, S.D.2
Dugger, T.C.3
Winnier, A.R.4
Robertson, J.B.5
-
17
-
-
0031974705
-
Therapeutic Application of AntiGrowth Factor Receptor Antibodies
-
Fan, Z.; Mendelsohn, J. Therapeutic Application of AntiGrowth Factor Receptor Antibodies. Curr. Opin. Oncol. 1998,10, 67-73.
-
(1998)
Curr. Opin. Oncol.
, vol.10
, pp. 67-73
-
-
Fan, Z.1
Mendelsohn, J.2
-
18
-
-
0033757346
-
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents
-
Ciardiello, F. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents. Drugs 2000, 60 Suppl. 1,25-32.
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 25-32
-
-
Ciardiello, F.1
-
19
-
-
0031921085
-
Cytotoxic Activity of EGF-Genistein Against Human Breast Cancer Cells
-
Uckun, F. M.; Jun, X.; Narla, R. K.; Zeren, T.; Venkatachalam, T.; Waddick, K.; Rostostev, A.; Myers, D. E. Cytotoxic Activity of EGF-Genistein Against Human Breast Cancer Cells. Clin. Cancer Res. 1998, 4, 901-912.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 901-912
-
-
Uckun, F.M.1
Jun, X.2
Narla, R.K.3
Zeren, T.4
Venkatachalam, T.5
Waddick, K.6
Rostostev, A.7
Myers, D.E.8
-
20
-
-
14444272510
-
In Vivo Toxicity, Pharmacokinetics, and Anticancer Activity of Genistein Linked to Recombinant Human Epidermal Growth Factor
-
Uckun, F. M.; Narla, R. K.; Zeren, T.; Yanishevski, Y.; Myers, D. E.; Waurzyniak, B.; Ek, O.; Schneider, E.; Messinger, Y.; Chelstrom, L. M.; Günther, R.; Evans, W. In Vivo Toxicity, Pharmacokinetics, and Anticancer Activity of Genistein Linked to Recombinant Human Epidermal Growth Factor. Clin. Cancer Res. 1998, 4, 1125-1134.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 1125-1134
-
-
Uckun, F.M.1
Narla, R.K.2
Zeren, T.3
Yanishevski, Y.4
Myers, D.E.5
Waurzyniak, B.6
Ek, O.7
Schneider, E.8
Messinger, Y.9
Chelstrom, L.M.10
Günther, R.11
Evans, W.12
-
21
-
-
0023664272
-
Genistein, a Specific Inhibitor of Tyrosine-Specific Protein Kinases
-
Akiyama, T.; Ishida, J.; Nakagawa, S.; Ogawara, H.; Watanabe, S.; Itoh, N.; Shibuya, M.; Fukami, Y. Genistein, a Specific Inhibitor of Tyrosine-Specific Protein Kinases. J. Biol. Chem. 1987,262, 5592-5595.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 5592-5595
-
-
Akiyama, T.1
Ishida, J.2
Nakagawa, S.3
Ogawara, H.4
Watanabe, S.5
Itoh, N.6
Shibuya, M.7
Fukami, Y.8
-
22
-
-
9844235351
-
Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4(Phenylamino)pyrazolo[3,4-d]pyrimidines
-
Traxler, P.; Bold, G.; Frei, J.; Lang, M.; Lydon, N.; Mett, H.; Buchdunger, E.; Meyer, T.; Mueller, M.; Furet, P. Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4(Phenylamino)pyrazolo[3,4-d]pyrimidines. J. Med. Chem. 1997, 40, 3601-3616.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3601-3616
-
-
Traxler, P.1
Bold, G.2
Frei, J.3
Lang, M.4
Lydon, N.5
Mett, H.6
Buchdunger, E.7
Meyer, T.8
Mueller, M.9
Furet, P.10
-
23
-
-
0030774045
-
Induction of Apoptosis and Cell Cycle Arrest by CP358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase
-
Moyer, J. D,; Barbacci, E. G.; Iwata, K. K.; Arnold, L.; Boman, B.; Cunningham, A.; DiOrio, C.; Doty, J.; Morin, M. J.; Moyer, M. P.; Neveu, M.; Pollack, V. A.; Pustilnik, L. R.; Reynolds, M. M.; Sloan, D.; Theleman, A.; Miller, P. Induction of Apoptosis and Cell Cycle Arrest by CP358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase. Cancer Res. 1997, 57, 48384848.
-
(1997)
Cancer Res.
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
Diorio, C.7
Doty, J.8
Morin, M.J.9
Moyer, M.P.10
Neveu, M.11
Pollack, V.A.12
Pustilnik, L.R.13
Reynolds, M.M.14
Sloan, D.15
Theleman, A.16
Miller, P.17
-
24
-
-
0028142387
-
A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase
-
Fry, D. W.; Kraker, A. J.; McMichael, A.; Ambrose, L. A.; Nelson, J. M.; Leopold, W. R.; Connors, R. W.; Bridges, A. J. A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase. Science 1994, 265, 10931095.
-
(1994)
Science
, vol.265
, pp. 1093-1095
-
-
Fry, D.W.1
Kraker, A.J.2
McMichael, A.3
Ambrose, L.A.4
Nelson, J.M.5
Leopold, W.R.6
Connors, R.W.7
Bridges, A.J.8
-
25
-
-
0030039555
-
Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure-Activity Relationship for Analogues -of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent inhibitor of the Epidermal Growth Factor Receptor
-
Bridges, A. J.; Zhou, H.; Cody, D. R.; Rewcastle, G. W.; McMichael, A.; Showalter, H. D.; Fry, D. W.; Kraker, A. J.; Denny, W. A. Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure-Activity Relationship for Analogues -of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent inhibitor of the Epidermal Growth Factor Receptor. J. Med. Chem. 1996, 39, 267-276.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 267-276
-
-
Bridges, A.J.1
Zhou, H.2
Cody, D.R.3
Rewcastle, G.W.4
McMichael, A.5
Showalter, H.D.6
Fry, D.W.7
Kraker, A.J.8
Denny, W.A.9
-
26
-
-
13144266690
-
Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor
-
Fry, D. W.; Bridges, A. J.; Denny, W. A.; Doherty, A.; Greis, K. D.; Hicks, J. L.; Hook, K. E.; Keller, P. R.; Leopold, W. R.; Loo, J. A.; McNamara, D. J.; Nelson, J. M.; Sherwood, V.; Smaill, J. B.; Trumpp-Kallmeyer, S.; Dobrusin, E. M. Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor. Proc. Natl. Acad. Sei. USA 1998, 95, 12022-12027.
-
(1998)
Proc. Natl. Acad. Sei. USA
, vol.95
, pp. 12022-12027
-
-
Fry, D.W.1
Bridges, A.J.2
Denny, W.A.3
Doherty, A.4
Greis, K.D.5
Hicks, J.L.6
Hook, K.E.7
Keller, P.R.8
Leopold, W.R.9
Loo, J.A.10
McNamara, D.J.11
Nelson, J.M.12
Sherwood, V.13
Smaill, J.B.14
Trumpp-Kallmeyer, S.15
Dobrusin, E.M.16
-
27
-
-
0034665713
-
Structural Mechanism for STI571 inhibition of Abelson Tyrosine Kinase
-
Schindler, T.; Bornmann, W.; Pellicena, P.; Miller, W. T.; Clarkson, B.; Kuriyan, J. Structural Mechanism for STI571 [inhibition of Abelson Tyrosine Kinase. Science 2000, 289, 1938-1942.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
28
-
-
0027408171
-
Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor
-
Zheng, J.; Knighton, D. R.; Ten Eyck, L. F.; Karlsson, R.; Xuong, N.; Taylor, S. S.; Sowadski, J. M. Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor. Biochemistry 1993,32, 2154-61.
-
(1993)
Biochemistry
, vol.32
, pp. 2154-2161
-
-
Zheng, J.1
Knighton, D.R.2
Ten Eyck, L.F.3
Karlsson, R.4
Xuong, N.5
Taylor, S.S.6
Sowadski, J.M.7
-
29
-
-
0030008414
-
4-(PhenyIamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase
-
Traxler, P. M.; Furet, P.; Mett, H.; Buchdunger, E.; Meyer, T.; Lydon, N. 4-(PhenyIamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase. J. Med. Chem. 1996, 39, 2285-2292.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2285-2292
-
-
Traxler, P.M.1
Furet, P.2
Mett, H.3
Buchdunger, E.4
Meyer, T.5
Lydon, N.6
-
30
-
-
0033602541
-
Use of a Pharmacophore Model for the Design of EGFR Tyrosine Kinase Inhibitors: Isoflavones and 3-Phenyl4(1H)-quinolones
-
Traxler, P.; Green, J.; Mett, H.; Sequin, U.; Furet, P. Use of a Pharmacophore Model for the Design of EGFR Tyrosine Kinase Inhibitors: Isoflavones and 3-Phenyl4(1H)-quinolones. J. Med. Chem. 1999,42, 1018-1026.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 1018-1026
-
-
Traxler, P.1
Green, J.2
Mett, H.3
Sequin, U.4
Furet, P.5
-
31
-
-
0030907052
-
Tyrosine Kinase Knhibitors. 11. Soluble Analogues of Pyrrolo- And Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding
-
[31 ] Palmer, B. D.; Trumpp-Kallmeyer, S.; Fry, D. W.; Nelson, J. M.; Showalter, H. D.; Denny, W. A. Tyrosine Kinase Knhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding. J. Med. Chem. 1991,40, 1519-1529.
-
(1991)
J. Med. Chem.
, vol.40
, pp. 1519-1529
-
-
Palmer, B.D.1
Trumpp-Kallmeyer, S.2
Fry, D.W.3
Nelson, J.M.4
Showalter, H.D.5
Denny, W.A.6
-
32
-
-
0032554818
-
Hollis Showalter, H. D. Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors
-
Trumpp-Kallmeyer, S.; Rubin, J. R.; Humblet, C.; Hamby, J. M.; Hollis Showalter, H. D. Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors. J. Med. Chem. 1998, 41, 1752-1763.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1752-1763
-
-
Trumpp-Kallmeyer, S.1
Rubin, J.R.2
Humblet, C.3
Hamby, J.M.4
-
33
-
-
0031785254
-
Cyano-j8-hydroxy-/3-methyl-W-[4-(trifluoromethoxy)phenyl]propenamide: An Inhibitor of the EGF Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells
-
Ghosh, S.; Zheng, Y.; Jun, X.; Narla, R.; Mahajan, S.; Navara, C.; Mao, C.; Sudbeck, E. A.; Uckun, F. M. aCyano-j8-hydroxy-/3-methyl-W-[4-(trifluoromethoxy)phenyl]propenamide: An Inhibitor of the EGF Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells. Clin. Can. Res. 1998, 4, 2657-2668.
-
(1998)
Clin. Can. Res.
, vol.4
, pp. 2657-2668
-
-
Ghosh, S.1
Zheng, Y.2
Jun, X.3
Narla, R.4
Mahajan, S.5
Navara, C.6
Mao, C.7
Sudbeck, E.A.8
Uckun, F.M.9
-
34
-
-
0031034930
-
Crystal Structure of the Src Family Tyrosine Kinase Hck
-
Sicheri, F.; Moarefi, I.; Kuriyan, J. Crystal Structure of the Src Family Tyrosine Kinase Hck. Nature 1997, 385, 602609.
-
(1997)
Nature
, vol.385
, pp. 602609
-
-
Sicheri, F.1
Moarefi, I.2
Kuriyan, J.3
-
35
-
-
0030945871
-
Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors
-
Mohammadi, M.; McMahon, G.; Sun, L.; Tang, C.; Hirth, P.; Yeh, B. K.; Hubbard, S. R.; Schlessinger, J. Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors. Science 1997, 276, 955-960.
-
(1997)
Science
, vol.276
, pp. 955-960
-
-
Mohammadi, M.1
McMahon, G.2
Sun, L.3
Tang, C.4
Hirth, P.5
Yeh, B.K.6
Hubbard, S.R.7
Schlessinger, J.8
-
36
-
-
0030766163
-
Crystal Structure of the Activated Insulin Receptor Tyrosine Kinase in Complex with Peptide Substrate and ATP Analog
-
Hubbard, S. R. Crystal Structure of the Activated Insulin Receptor Tyrosine Kinase in Complex with Peptide Substrate and ATP Analog. EMBO J. 1997, 16, 55725581.
-
(1997)
EMBO J.
, vol.16
, pp. 5572-5581
-
-
Hubbard, S.R.1
-
37
-
-
0000127673
-
Refined Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with Mn, ATP and a Peptide Inhibitor
-
Zheng, J.; Trafny, E. A.; Knighton, D. R.; Xuong, N.-H.; Taylor, S. S.; Ten Eyck, L. F.; Sowadski, J. M. 2.2Ä Refined Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with Mn, ATP and a Peptide Inhibitor. Acta Cryst. 1993, D49, 362-365.
-
(1993)
Acta Cryst.
, vol.49
, pp. 362-365
-
-
Zheng, J.1
Trafny, E.A.2
Knighton, D.R.3
Xuong, N.-H.4
Taylor, S.S.5
Ten Eyck, L.F.6
Sowadski, J.M.7
-
38
-
-
0029117648
-
Leflunomide : A Potential New Disease Modifying Anti-rheumatic Drug
-
Parnham, M. J. Leflunomide : A Potential New Disease Modifying Anti-rheumatic Drug. Expert Opin. Invest. Drugs 1995, 4, 777-779.
-
(1995)
Expert Opin. Invest. Drugs
, vol.4
, pp. 777-779
-
-
Parnham, M.J.1
-
39
-
-
0030014489
-
Two Activities of the Immunosuppressive Metabolite of Leflunomide, A77 1726. Inhibition of Pyrimidine Nucleotide Synthesis and Protein Tyrosine Phosphorylation
-
Xu, X.; Williams, J. W.; Gong, H.; Finnegan, A.; Chong, A. S. Two Activities of the Immunosuppressive Metabolite of Leflunomide, A77 1726. Inhibition of Pyrimidine Nucleotide Synthesis and Protein Tyrosine Phosphorylation. Biochem. Pharmacol. 1996, 52, 527534.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 527-534
-
-
Xu, X.1
Williams, J.W.2
Gong, H.3
Finnegan, A.4
Chong, A.S.5
-
40
-
-
0027501428
-
Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity by Leflunomide
-
Mattar, T.; Kochhar, K.; Bartlett, R.; Bremer, E. G.; Finnegan, A. Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity by Leflunomide. FEBS Lett. 1993, 334; 161-164.
-
(1993)
FEBS Lett.
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Bartlett, R.3
Bremer, E.G.4
Finnegan, A.5
-
41
-
-
0033505039
-
Structure-Based Design of Potent Inhibitors of EGF-Receptor Tyrosine Kinase as Anti-cancer Agents
-
Ghosh, S.; Narla, R. K.; Zheng, Y.; Liu, X.-P.; Jun, X.; Mao, C.; Sudbeck, E. A.; Uckun, F. M. Structure-Based Design of Potent Inhibitors of EGF-Receptor Tyrosine Kinase as Anti-cancer Agents. Anticancer Drug Des. 1999, 403-410.
-
(1999)
Anticancer Drug Des.
, pp. 403-410
-
-
Ghosh, S.1
Narla, R.K.2
Zheng, Y.3
Liu, X.-P.4
Jun, X.5
Mao, C.6
Sudbeck, E.A.7
Uckun, F.M.8
-
42
-
-
0000561483
-
Alpha-Cyano-N-(2,5dibromophenyl)-beta-hydroxybut-2-enamide
-
Ghosh, S.; Uckun, F. M. alpha-Cyano-N-(2,5dibromophenyl)-beta-hydroxybut-2-enamide. Act a Cryst. C 1999, 55, 1364-1365.
-
(1999)
Act A Cryst. C
, vol.55
, pp. 1364-1365
-
-
Ghosh, S.1
Uckun, F.M.2
-
43
-
-
0042815662
-
Five Analogs of the Active Metabolite of Leflunomide
-
Ghosh, S.; Zheng, Y.; Uckun, F. M. Five Analogs of the Active Metabolite of Leflunomide. Acta Cryst. C 1999, 55, 2117-2122.
-
(1999)
Acta Cryst. C
, vol.55
, pp. 2117-2122
-
-
Ghosh, S.1
Zheng, Y.2
Uckun, F.M.3
-
44
-
-
0034293754
-
Three Leflunomide Metabolite Analogs
-
Ghosh, S.; Jennissen, J. D.; Zheng, Y.; Uckun, F. M. Three Leflunomide Metabolite Analogs. Acta Cryst. C 2000,56, 1254-1257.
-
(2000)
Acta Cryst. C
, vol.56
, pp. 1254-1257
-
-
Ghosh, S.1
Jennissen, J.D.2
Zheng, Y.3
Uckun, F.M.4
-
45
-
-
18044376460
-
An Inhibitor of Janus Kinase 3: 4-(4HydroxyphenyIamino)-6,7-dimethoxyquinazolin-l-ium Chloride Methanol Solvate
-
Sudbeck, E. A.; Jennissen, J. D.; Liu, X.-P.; Uckun, F. M. An Inhibitor of Janus Kinase 3: 4-(4HydroxyphenyIamino)-6,7-dimethoxyquinazolin-l-ium Chloride Methanol Solvate. Acta Cryst. C 2000, 56 1282-1283.
-
(2000)
Acta Cryst. C
, vol.56
, pp. 1282-1283
-
-
Sudbeck, E.A.1
Jennissen, J.D.2
Liu, X.-P.3
Uckun, F.M.4
-
46
-
-
0034741285
-
4[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium Chloride Methanol Solvate and 4-[(3Hydroxyphenyl)amino]-6,7-dimethoxy-l-quinazolinium Chloride
-
Ghosh, S.; Jennissen, J. D.; Liu, X.-P.; Uckun, F. M. 4[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium Chloride Methanol Solvate and 4-[(3Hydroxyphenyl)amino]-6,7-dimethoxy-l-quinazolinium Chloride. Acta Cryst. C 2001, 57, 76-78.
-
(2001)
Acta Cryst. C
, vol.57
, pp. 76-78
-
-
Ghosh, S.1
Jennissen, J.D.2
Liu, X.-P.3
Uckun, F.M.4
-
47
-
-
0033053383
-
Structure-Based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-Inducing Anti-leukemic Agents
-
Sudbeck, E. A.; Liu, X.-P.; Narla, R. K.; Mahajan, S.; Ghosh, S.; Mao, C.; Uckun, F. M. Structure-Based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-Inducing Anti-leukemic Agents. Clin. Cancer Res. 1999, 5, 1569-1582.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1569-1582
-
-
Sudbeck, E.A.1
Liu, X.-P.2
Narla, R.K.3
Mahajan, S.4
Ghosh, S.5
Mao, C.6
Uckun, F.M.7
-
48
-
-
0033515450
-
. Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK): LFM-A13 [a-Cyano-hydroxy-methyl-N-(2,5-dibromophenyl)propenamide]
-
Mahajan, S.; Ghosh,.S.; Sudbeck, E. A.; Zheng, Y.; Downs, S.; Hupke, M.; Uckun, F. M. Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK): LFM-A13 [a-Cyano-hydroxy-methyl-N-(2,5-dibromophenyl)propenamide]. J. Biol. Chem. 1999, 274, 9587-9599.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9587-9599
-
-
Mahajan, S.1
Ghosh, S.2
Sudbeck, E.A.3
Zheng, Y.4
Downs, S.5
Hupke, M.6
Uckun, F.M.7
-
49
-
-
0031801528
-
4-(3'Bromo-4' hydroxyIphenyl)-amino-6,7dimethoxyquinazoline: A Novel Quinazoline Derivative with Potent Cytotoxic Activity Against Human Glioblastoma Cells
-
Narla, R. K.; Liu, X.-P.; Myers, D. E.; Uckun, F. M. 4-(3'Bromo-4' hydroxyIphenyl)-amino-6,7dimethoxyquinazoline: A Novel Quinazoline Derivative with Potent Cytotoxic Activity Against Human Glioblastoma Cells. Clin. Can. Res. 1998,4, 1405-1414.
-
(1998)
Clin. Can. Res.
, vol.4
, pp. 1405-1414
-
-
Narla, R.K.1
Liu, X.-P.2
Myers, D.E.3
Uckun, F.M.4
-
50
-
-
0000913086
-
A Fast Algorithm for Rendering Space-Filling Molecule Pictures
-
Bacon, D. J.; Anderson, W. F. A Fast Algorithm for Rendering Space-Filling Molecule Pictures. J. Molec. Graphics 1988, 6, 219-220.
-
(1988)
J. Molec. Graphics
, vol.6
, pp. 219-220
-
-
Bacon, D.J.1
Anderson, W.F.2
-
51
-
-
0026244229
-
MOLSCR1PT: A Program to Produce both Detailed and Schematic Plots of Proteins
-
Kraulis, P. MOLSCR1PT: A Program to Produce both Detailed and Schematic Plots of Proteins. J. Appl Cryst. 1991,24, 946-950.
-
(1991)
J. Appl Cryst.
, vol.24
, pp. 946-950
-
-
Kraulis, P.1
-
52
-
-
0028057108
-
Raster3D Version 2.0 A Program for Photorealistic Molecular Graphics
-
Merritt, E. A.; Murphy, M. E. P. Raster3D Version 2.0 A Program for Photorealistic Molecular Graphics. Acta Cryst. D 1994, 50, 869-873.
-
(1994)
Acta Cryst. D
, vol.50
, pp. 869-873
-
-
Merritt, E.A.1
Murphy, M.E.P.2
-
53
-
-
0027027467
-
LUDI: Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads
-
Bohm, H. J. LUDI: Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads. J. Comput. Aided Mol Des. 1992, 6, 593-606.
-
(1992)
J. Comput. Aided Mol Des.
, vol.6
, pp. 593-606
-
-
Bohm, H.J.1
-
54
-
-
0028454828
-
The Development of a Simple Empirical Scoring Function to Estimate the Binding Constant for a Protein-Ligand Complex of Known Three-Dimensional Structure
-
Bohm, H. J. The Development of a Simple Empirical Scoring Function to Estimate the Binding Constant for a Protein-Ligand Complex of Known Three-Dimensional Structure. J. Comput. Aided Mol. Des. 1994, 8, 243-256.
-
(1994)
J. Comput. Aided Mol. Des.
, vol.8
, pp. 243-256
-
-
Bohm, H.J.1
|