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Volumn 1, Issue 2, 2001, Pages 129-140

Rational design of potent and selective EGFR tyrosine kinase inhibitors as anticancer agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND;

EID: 0035428019     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568009013334188     Document Type: Article
Times cited : (24)

References (54)
  • 1
    • 0026316096 scopus 로고
    • Growth Factors and Cancer
    • Aaronson, S. A. Growth Factors and Cancer. Science 1991,254, 1146-1152.
    • (1991) Science , vol.254 , pp. 1146-1152
    • Aaronson, S.A.1
  • 2
    • 0029020282 scopus 로고
    • Protein Kinases 6. the Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification
    • Hanks, S. K.; Hunter, T. Protein Kinases 6. The Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification. FASEB J. 1995, 9, 576-96.
    • (1995) FASEB J. , vol.9 , pp. 576-596
    • Hanks, S.K.1    Hunter, T.2
  • 3
    • 0033026444 scopus 로고    scopus 로고
    • Strategies Toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors
    • Traxler, P.; Furet, P. Strategies Toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors. Pharmacol Ther. 1999, 82, 195-206.
    • (1999) Pharmacol Ther. , vol.82 , pp. 195-206
    • Traxler, P.1    Furet, P.2
  • 4
    • 0033757709 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Anticancer Therapy
    • Raymond, E.; Faivre, S.; Armand, J. P. Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Anticancer Therapy. Drugs 2000, 60, Suppl 1, 15-2.
    • (2000) Drugs , vol.60 , Issue.1 SUPPL. , pp. 15-22
    • Raymond, E.1    Faivre, S.2    Armand, J.P.3
  • 5
    • 0024328467 scopus 로고
    • Epidermal Growth Factor: The Receptor and its Function
    • Todderud, G.; Carpenter, G. Epidermal Growth Factor: The Receptor and its Function. Biofactors 1989,2, 1115.
    • (1989) Biofactors , vol.2 , pp. 1115
    • Todderud, G.1    Carpenter, G.2
  • 6
    • 0031684721 scopus 로고    scopus 로고
    • The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy
    • Ross, J. S.; Fletcher, J. A. The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy. Oncologist 1998, 3, 237-252.
    • (1998) Oncologist , vol.3 , pp. 237-252
    • Ross, J.S.1    Fletcher, J.A.2
  • 7
    • 0025874765 scopus 로고
    • Epidermal Growth'Factor Receptor Expression as a Prognostic Indicator in Breast Cancer
    • Toi, M.; Osaki, A.; Yamada, H.; Toge, T. Epidermal Growth'Factor Receptor Expression as a Prognostic Indicator in Breast Cancer. Eur. J. Cancer 1991, 27, 97780.
    • (1991) Eur. J. Cancer , vol.27 , pp. 97780
    • Toi, M.1    Osaki, A.2    Yamada, H.3    Toge, T.4
  • 8
    • 0028266876 scopus 로고
    • EOF Receptor Expression, Regulation, and Function in Breast Cancer
    • Chrysogelos, S.; Dickson, R. EOF Receptor Expression, Regulation, and Function in Breast Cancer. Breast CancerRes. Treat. 1994, 29, 29-40.
    • (1994) Breast CancerRes. Treat. , vol.29 , pp. 29-40
    • Chrysogelos, S.1    Dickson, R.2
  • 11
    • 0028879656 scopus 로고
    • Inhibitors of Protein Tyrosine Kinases
    • Fry, D. W.; Bridges, A. J. Inhibitors of Protein Tyrosine Kinases. Curr. Opin. Biotechnol. 1995, 6, 662-667.
    • (1995) Curr. Opin. Biotechnol. , vol.6 , pp. 662-667
    • Fry, D.W.1    Bridges, A.J.2
  • 13
    • 0031887743 scopus 로고    scopus 로고
    • Protein Kinase Inhibitors: The Tyrosine-Specific Protein Kinases
    • Lawrence, D. S.; Niu, J. Protein Kinase Inhibitors: The Tyrosine-Specific Protein Kinases. Pharmacol. Ther. 1998,77, 81-114.
    • (1998) Pharmacol. Ther. , vol.77 , pp. 81-114
    • Lawrence, D.S.1    Niu, J.2
  • 14
    • 0029021518 scopus 로고
    • Heterodimerization and Functional Interaction between EGF Receptor Family Members: A New Signaling Paradigm with Implications for Breast Cancer Research
    • Earp, H. S.; Dawson, T. L.; Li, X.; Yu, H. Heterodimerization and Functional Interaction between EGF Receptor Family Members: A New Signaling Paradigm with Implications for Breast Cancer Research. Breast Cancer Res. Treat. 1995,35, 115-132.
    • (1995) Breast Cancer Res. Treat. , vol.35 , pp. 115-132
    • Earp, H.S.1    Dawson, T.L.2    Li, X.3    Yu, H.4
  • 15
    • 0029067672 scopus 로고
    • . An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-Defective Epidermal Growth Factor Receptors
    • Wright, J. D.; Reuter, C. W.; Weber, M. J. An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-Defective Epidermal Growth Factor Receptors. J. Biol. Chem. 1995, 270, 12085-93.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12085-12093
    • Wright, J.D.1    Reuter, C.W.2    Weber, M.J.3
  • 16
    • 0027935422 scopus 로고
    • Epidermal Growth Factor Receptors in Human Breast Carcinoma Cells: A Potential Selective Target for Transforming Growth Factor AlphaPseudomonas Exotoxin 40 Fusion Protein
    • Arteaga, C. L.; Hurd, S. D.; Dugger, T. C.; Winnier, A. R.; Robertson, J. B. Epidermal Growth Factor Receptors in Human Breast Carcinoma Cells: A Potential Selective Target for Transforming Growth Factor AlphaPseudomonas Exotoxin 40 Fusion Protein. Cancer Res. 1994, 54, 4703-9.
    • (1994) Cancer Res. , vol.54 , pp. 4703-4709
    • Arteaga, C.L.1    Hurd, S.D.2    Dugger, T.C.3    Winnier, A.R.4    Robertson, J.B.5
  • 17
    • 0031974705 scopus 로고    scopus 로고
    • Therapeutic Application of AntiGrowth Factor Receptor Antibodies
    • Fan, Z.; Mendelsohn, J. Therapeutic Application of AntiGrowth Factor Receptor Antibodies. Curr. Opin. Oncol. 1998,10, 67-73.
    • (1998) Curr. Opin. Oncol. , vol.10 , pp. 67-73
    • Fan, Z.1    Mendelsohn, J.2
  • 18
    • 0033757346 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents
    • Ciardiello, F. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents. Drugs 2000, 60 Suppl. 1,25-32.
    • (2000) Drugs , vol.60 , Issue.SUPPL. 1 , pp. 25-32
    • Ciardiello, F.1
  • 22
    • 9844235351 scopus 로고    scopus 로고
    • Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4(Phenylamino)pyrazolo[3,4-d]pyrimidines
    • Traxler, P.; Bold, G.; Frei, J.; Lang, M.; Lydon, N.; Mett, H.; Buchdunger, E.; Meyer, T.; Mueller, M.; Furet, P. Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4(Phenylamino)pyrazolo[3,4-d]pyrimidines. J. Med. Chem. 1997, 40, 3601-3616.
    • (1997) J. Med. Chem. , vol.40 , pp. 3601-3616
    • Traxler, P.1    Bold, G.2    Frei, J.3    Lang, M.4    Lydon, N.5    Mett, H.6    Buchdunger, E.7    Meyer, T.8    Mueller, M.9    Furet, P.10
  • 25
    • 0030039555 scopus 로고    scopus 로고
    • Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure-Activity Relationship for Analogues -of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent inhibitor of the Epidermal Growth Factor Receptor
    • Bridges, A. J.; Zhou, H.; Cody, D. R.; Rewcastle, G. W.; McMichael, A.; Showalter, H. D.; Fry, D. W.; Kraker, A. J.; Denny, W. A. Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure-Activity Relationship for Analogues -of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent inhibitor of the Epidermal Growth Factor Receptor. J. Med. Chem. 1996, 39, 267-276.
    • (1996) J. Med. Chem. , vol.39 , pp. 267-276
    • Bridges, A.J.1    Zhou, H.2    Cody, D.R.3    Rewcastle, G.W.4    McMichael, A.5    Showalter, H.D.6    Fry, D.W.7    Kraker, A.J.8    Denny, W.A.9
  • 28
    • 0027408171 scopus 로고
    • Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor
    • Zheng, J.; Knighton, D. R.; Ten Eyck, L. F.; Karlsson, R.; Xuong, N.; Taylor, S. S.; Sowadski, J. M. Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor. Biochemistry 1993,32, 2154-61.
    • (1993) Biochemistry , vol.32 , pp. 2154-2161
    • Zheng, J.1    Knighton, D.R.2    Ten Eyck, L.F.3    Karlsson, R.4    Xuong, N.5    Taylor, S.S.6    Sowadski, J.M.7
  • 29
    • 0030008414 scopus 로고    scopus 로고
    • 4-(PhenyIamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase
    • Traxler, P. M.; Furet, P.; Mett, H.; Buchdunger, E.; Meyer, T.; Lydon, N. 4-(PhenyIamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase. J. Med. Chem. 1996, 39, 2285-2292.
    • (1996) J. Med. Chem. , vol.39 , pp. 2285-2292
    • Traxler, P.M.1    Furet, P.2    Mett, H.3    Buchdunger, E.4    Meyer, T.5    Lydon, N.6
  • 30
    • 0033602541 scopus 로고    scopus 로고
    • Use of a Pharmacophore Model for the Design of EGFR Tyrosine Kinase Inhibitors: Isoflavones and 3-Phenyl4(1H)-quinolones
    • Traxler, P.; Green, J.; Mett, H.; Sequin, U.; Furet, P. Use of a Pharmacophore Model for the Design of EGFR Tyrosine Kinase Inhibitors: Isoflavones and 3-Phenyl4(1H)-quinolones. J. Med. Chem. 1999,42, 1018-1026.
    • (1999) J. Med. Chem. , vol.42 , pp. 1018-1026
    • Traxler, P.1    Green, J.2    Mett, H.3    Sequin, U.4    Furet, P.5
  • 31
    • 0030907052 scopus 로고
    • Tyrosine Kinase Knhibitors. 11. Soluble Analogues of Pyrrolo- And Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding
    • [31 ] Palmer, B. D.; Trumpp-Kallmeyer, S.; Fry, D. W.; Nelson, J. M.; Showalter, H. D.; Denny, W. A. Tyrosine Kinase Knhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding. J. Med. Chem. 1991,40, 1519-1529.
    • (1991) J. Med. Chem. , vol.40 , pp. 1519-1529
    • Palmer, B.D.1    Trumpp-Kallmeyer, S.2    Fry, D.W.3    Nelson, J.M.4    Showalter, H.D.5    Denny, W.A.6
  • 32
    • 0032554818 scopus 로고    scopus 로고
    • Hollis Showalter, H. D. Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors
    • Trumpp-Kallmeyer, S.; Rubin, J. R.; Humblet, C.; Hamby, J. M.; Hollis Showalter, H. D. Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors. J. Med. Chem. 1998, 41, 1752-1763.
    • (1998) J. Med. Chem. , vol.41 , pp. 1752-1763
    • Trumpp-Kallmeyer, S.1    Rubin, J.R.2    Humblet, C.3    Hamby, J.M.4
  • 33
    • 0031785254 scopus 로고    scopus 로고
    • Cyano-j8-hydroxy-/3-methyl-W-[4-(trifluoromethoxy)phenyl]propenamide: An Inhibitor of the EGF Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells
    • Ghosh, S.; Zheng, Y.; Jun, X.; Narla, R.; Mahajan, S.; Navara, C.; Mao, C.; Sudbeck, E. A.; Uckun, F. M. aCyano-j8-hydroxy-/3-methyl-W-[4-(trifluoromethoxy)phenyl]propenamide: An Inhibitor of the EGF Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells. Clin. Can. Res. 1998, 4, 2657-2668.
    • (1998) Clin. Can. Res. , vol.4 , pp. 2657-2668
    • Ghosh, S.1    Zheng, Y.2    Jun, X.3    Narla, R.4    Mahajan, S.5    Navara, C.6    Mao, C.7    Sudbeck, E.A.8    Uckun, F.M.9
  • 34
    • 0031034930 scopus 로고    scopus 로고
    • Crystal Structure of the Src Family Tyrosine Kinase Hck
    • Sicheri, F.; Moarefi, I.; Kuriyan, J. Crystal Structure of the Src Family Tyrosine Kinase Hck. Nature 1997, 385, 602609.
    • (1997) Nature , vol.385 , pp. 602609
    • Sicheri, F.1    Moarefi, I.2    Kuriyan, J.3
  • 35
    • 0030945871 scopus 로고    scopus 로고
    • Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors
    • Mohammadi, M.; McMahon, G.; Sun, L.; Tang, C.; Hirth, P.; Yeh, B. K.; Hubbard, S. R.; Schlessinger, J. Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors. Science 1997, 276, 955-960.
    • (1997) Science , vol.276 , pp. 955-960
    • Mohammadi, M.1    McMahon, G.2    Sun, L.3    Tang, C.4    Hirth, P.5    Yeh, B.K.6    Hubbard, S.R.7    Schlessinger, J.8
  • 36
    • 0030766163 scopus 로고    scopus 로고
    • Crystal Structure of the Activated Insulin Receptor Tyrosine Kinase in Complex with Peptide Substrate and ATP Analog
    • Hubbard, S. R. Crystal Structure of the Activated Insulin Receptor Tyrosine Kinase in Complex with Peptide Substrate and ATP Analog. EMBO J. 1997, 16, 55725581.
    • (1997) EMBO J. , vol.16 , pp. 5572-5581
    • Hubbard, S.R.1
  • 37
    • 0000127673 scopus 로고
    • Refined Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with Mn, ATP and a Peptide Inhibitor
    • Zheng, J.; Trafny, E. A.; Knighton, D. R.; Xuong, N.-H.; Taylor, S. S.; Ten Eyck, L. F.; Sowadski, J. M. 2.2Ä Refined Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with Mn, ATP and a Peptide Inhibitor. Acta Cryst. 1993, D49, 362-365.
    • (1993) Acta Cryst. , vol.49 , pp. 362-365
    • Zheng, J.1    Trafny, E.A.2    Knighton, D.R.3    Xuong, N.-H.4    Taylor, S.S.5    Ten Eyck, L.F.6    Sowadski, J.M.7
  • 38
    • 0029117648 scopus 로고
    • Leflunomide : A Potential New Disease Modifying Anti-rheumatic Drug
    • Parnham, M. J. Leflunomide : A Potential New Disease Modifying Anti-rheumatic Drug. Expert Opin. Invest. Drugs 1995, 4, 777-779.
    • (1995) Expert Opin. Invest. Drugs , vol.4 , pp. 777-779
    • Parnham, M.J.1
  • 39
    • 0030014489 scopus 로고    scopus 로고
    • Two Activities of the Immunosuppressive Metabolite of Leflunomide, A77 1726. Inhibition of Pyrimidine Nucleotide Synthesis and Protein Tyrosine Phosphorylation
    • Xu, X.; Williams, J. W.; Gong, H.; Finnegan, A.; Chong, A. S. Two Activities of the Immunosuppressive Metabolite of Leflunomide, A77 1726. Inhibition of Pyrimidine Nucleotide Synthesis and Protein Tyrosine Phosphorylation. Biochem. Pharmacol. 1996, 52, 527534.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 527-534
    • Xu, X.1    Williams, J.W.2    Gong, H.3    Finnegan, A.4    Chong, A.S.5
  • 40
    • 0027501428 scopus 로고
    • Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity by Leflunomide
    • Mattar, T.; Kochhar, K.; Bartlett, R.; Bremer, E. G.; Finnegan, A. Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity by Leflunomide. FEBS Lett. 1993, 334; 161-164.
    • (1993) FEBS Lett. , vol.334 , pp. 161-164
    • Mattar, T.1    Kochhar, K.2    Bartlett, R.3    Bremer, E.G.4    Finnegan, A.5
  • 42
    • 0000561483 scopus 로고    scopus 로고
    • Alpha-Cyano-N-(2,5dibromophenyl)-beta-hydroxybut-2-enamide
    • Ghosh, S.; Uckun, F. M. alpha-Cyano-N-(2,5dibromophenyl)-beta-hydroxybut-2-enamide. Act a Cryst. C 1999, 55, 1364-1365.
    • (1999) Act A Cryst. C , vol.55 , pp. 1364-1365
    • Ghosh, S.1    Uckun, F.M.2
  • 43
    • 0042815662 scopus 로고    scopus 로고
    • Five Analogs of the Active Metabolite of Leflunomide
    • Ghosh, S.; Zheng, Y.; Uckun, F. M. Five Analogs of the Active Metabolite of Leflunomide. Acta Cryst. C 1999, 55, 2117-2122.
    • (1999) Acta Cryst. C , vol.55 , pp. 2117-2122
    • Ghosh, S.1    Zheng, Y.2    Uckun, F.M.3
  • 45
    • 18044376460 scopus 로고    scopus 로고
    • An Inhibitor of Janus Kinase 3: 4-(4HydroxyphenyIamino)-6,7-dimethoxyquinazolin-l-ium Chloride Methanol Solvate
    • Sudbeck, E. A.; Jennissen, J. D.; Liu, X.-P.; Uckun, F. M. An Inhibitor of Janus Kinase 3: 4-(4HydroxyphenyIamino)-6,7-dimethoxyquinazolin-l-ium Chloride Methanol Solvate. Acta Cryst. C 2000, 56 1282-1283.
    • (2000) Acta Cryst. C , vol.56 , pp. 1282-1283
    • Sudbeck, E.A.1    Jennissen, J.D.2    Liu, X.-P.3    Uckun, F.M.4
  • 46
    • 0034741285 scopus 로고    scopus 로고
    • 4[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium Chloride Methanol Solvate and 4-[(3Hydroxyphenyl)amino]-6,7-dimethoxy-l-quinazolinium Chloride
    • Ghosh, S.; Jennissen, J. D.; Liu, X.-P.; Uckun, F. M. 4[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium Chloride Methanol Solvate and 4-[(3Hydroxyphenyl)amino]-6,7-dimethoxy-l-quinazolinium Chloride. Acta Cryst. C 2001, 57, 76-78.
    • (2001) Acta Cryst. C , vol.57 , pp. 76-78
    • Ghosh, S.1    Jennissen, J.D.2    Liu, X.-P.3    Uckun, F.M.4
  • 47
    • 0033053383 scopus 로고    scopus 로고
    • Structure-Based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-Inducing Anti-leukemic Agents
    • Sudbeck, E. A.; Liu, X.-P.; Narla, R. K.; Mahajan, S.; Ghosh, S.; Mao, C.; Uckun, F. M. Structure-Based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-Inducing Anti-leukemic Agents. Clin. Cancer Res. 1999, 5, 1569-1582.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.-P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6    Uckun, F.M.7
  • 48
    • 0033515450 scopus 로고    scopus 로고
    • . Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK): LFM-A13 [a-Cyano-hydroxy-methyl-N-(2,5-dibromophenyl)propenamide]
    • Mahajan, S.; Ghosh,.S.; Sudbeck, E. A.; Zheng, Y.; Downs, S.; Hupke, M.; Uckun, F. M. Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK): LFM-A13 [a-Cyano-hydroxy-methyl-N-(2,5-dibromophenyl)propenamide]. J. Biol. Chem. 1999, 274, 9587-9599.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9587-9599
    • Mahajan, S.1    Ghosh, S.2    Sudbeck, E.A.3    Zheng, Y.4    Downs, S.5    Hupke, M.6    Uckun, F.M.7
  • 49
    • 0031801528 scopus 로고    scopus 로고
    • 4-(3'Bromo-4' hydroxyIphenyl)-amino-6,7dimethoxyquinazoline: A Novel Quinazoline Derivative with Potent Cytotoxic Activity Against Human Glioblastoma Cells
    • Narla, R. K.; Liu, X.-P.; Myers, D. E.; Uckun, F. M. 4-(3'Bromo-4' hydroxyIphenyl)-amino-6,7dimethoxyquinazoline: A Novel Quinazoline Derivative with Potent Cytotoxic Activity Against Human Glioblastoma Cells. Clin. Can. Res. 1998,4, 1405-1414.
    • (1998) Clin. Can. Res. , vol.4 , pp. 1405-1414
    • Narla, R.K.1    Liu, X.-P.2    Myers, D.E.3    Uckun, F.M.4
  • 50
    • 0000913086 scopus 로고
    • A Fast Algorithm for Rendering Space-Filling Molecule Pictures
    • Bacon, D. J.; Anderson, W. F. A Fast Algorithm for Rendering Space-Filling Molecule Pictures. J. Molec. Graphics 1988, 6, 219-220.
    • (1988) J. Molec. Graphics , vol.6 , pp. 219-220
    • Bacon, D.J.1    Anderson, W.F.2
  • 51
    • 0026244229 scopus 로고
    • MOLSCR1PT: A Program to Produce both Detailed and Schematic Plots of Proteins
    • Kraulis, P. MOLSCR1PT: A Program to Produce both Detailed and Schematic Plots of Proteins. J. Appl Cryst. 1991,24, 946-950.
    • (1991) J. Appl Cryst. , vol.24 , pp. 946-950
    • Kraulis, P.1
  • 52
    • 0028057108 scopus 로고
    • Raster3D Version 2.0 A Program for Photorealistic Molecular Graphics
    • Merritt, E. A.; Murphy, M. E. P. Raster3D Version 2.0 A Program for Photorealistic Molecular Graphics. Acta Cryst. D 1994, 50, 869-873.
    • (1994) Acta Cryst. D , vol.50 , pp. 869-873
    • Merritt, E.A.1    Murphy, M.E.P.2
  • 53
    • 0027027467 scopus 로고
    • LUDI: Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads
    • Bohm, H. J. LUDI: Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads. J. Comput. Aided Mol Des. 1992, 6, 593-606.
    • (1992) J. Comput. Aided Mol Des. , vol.6 , pp. 593-606
    • Bohm, H.J.1
  • 54
    • 0028454828 scopus 로고
    • The Development of a Simple Empirical Scoring Function to Estimate the Binding Constant for a Protein-Ligand Complex of Known Three-Dimensional Structure
    • Bohm, H. J. The Development of a Simple Empirical Scoring Function to Estimate the Binding Constant for a Protein-Ligand Complex of Known Three-Dimensional Structure. J. Comput. Aided Mol. Des. 1994, 8, 243-256.
    • (1994) J. Comput. Aided Mol. Des. , vol.8 , pp. 243-256
    • Bohm, H.J.1


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