Ypt and Rab GTPases: Insight into functions through novel interactions

Current Opinion in Cell Biology

Volumn 13, Issue 4, 2001, Pages 500-511

  Segev, N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN SEC; PROTEIN SUBUNIT; PROTEIN YPT; RAB PROTEIN; UNCLASSIFIED DRUG;

BINDING SITE; CROSS LINKING; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME REGULATION; EUKARYOTIC CELL; HUMAN; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; FUNGAL PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; TRANSPORT VESICLES;

EUKARYOTA;

EID: 0035425411     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00242-8     Document Type: Review

References (93)

1. A ras-like protein is required for a post-Golgi event in yeast secretion
2. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery
3. The GTP-binding protein Ypt1 is required for transport in vitro: The Golgi apparatus is defective in ypt1 mutants
4. 2+ function independently in a cell-free transport reaction
5. Vesicular transport: How many Ypt/Rab-GTPases make a eukaryotic cell?
6. Ypt/Rab GTPases: Regulators of protein trafficking
7. The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
8. Role of Rab GTPases in membrane traffic
9. Rab proteins as membrane organizers
10. Structural basis of activation and GTP hydrolysis in Rab proteins
11. Crystal structures of a rab protein in its inactive and active conformations
12. High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis
13. Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo. Rab-independent binding to membranes and role of Rab recycling factors
14. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion
15. Sec2 mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles
16. TRAPP stimulates guanine nucleotide exchange on ypt1p
17. The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32
18. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport
19. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p
20. New component of the vacuolar class C-Vps complex couples nucleotide exchange on the ypt7 GTPase to SNARE-dependent docking and fusion
21. Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport
22. TRAPP stably associates with the Golgi and is required for vesicle docking
23. Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain
24. A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion
25. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
26. The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission
27. Identification of regulators for Ypt1 GTPase nucleotide cycling
28. A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family
29. Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family
30. Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition
31. Msb4p, a protein involved in Cdc42p-dependent organization of the actin cytoskeleton, is a Ypt/Rab-specific GAP
32. Primary structure and biochemical characterization of yeast GTPase-activating proteins with substrate preference for the transport GTPase Ypt7p
33. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
34. The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
35. Crystal structure of the GAP domain of Gyp1p: First insights into interaction with Ypt/Rab proteins
36. GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport
37. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast
38. The role of ARF and Rab GTPases in membrane transport
39. How do Rab proteins function in membrane traffic?
40. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion
41. GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
42. The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway
43. VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment
44. Mediation of the attachment or fusion step in vesicular transport by the GTP-binding Ypt1 protein
45. Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment
46. A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits
47. Rab5 regulates motility of early endosomes on microtubules
48. Phosphatidylinositol-3-OH kinases are Rab5 effectors
49. Transport-vesicle targeting: Tethers before SNAREs
50. The Rab5 effector EEA1 is a core component of endosome docking
51. Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes
52. Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues
53. Rabenosyn-5, a novel rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain
54. The Rab5 effector EEA1 interacts directly with syntaxin-6
55. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
56. Direct interaction of EEA1 with Rab5b
57. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting
58. Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
59. Role of Rab9 GTPase in facilitating receptor recruitment by TIP47
60. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking
61. The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly
62. Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion
63. Cruising along microtubule highways: How membranes move through the secretory pathway
64. Interaction of a Golgi-associated kinesin-like protein with Rab6
65. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
66. The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo
67. The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic
68. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
69. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
70. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis
71. The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein
72. Membrane fusion and exocytosis
73. Promiscuity in Rab-SNARE interactions
74. Sec1/Munc18 proteins: Mediators of membrane fusion moving to center stage
75. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A
76. GTPase cascades choreographing cellular behavior: Movement, morphogenesis and more
77. Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers
78. Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5
79. Involvement of Rabphilin3 in endocytosis through interaction with Rabaptin5
80. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex
81. Epidermal growth factor and membrane trafficking. Egf receptor activation of endocytosis requires rab5a
82. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
83. Gradient formation of the TGF-beta homolog Dpp
84. A genomic perspective on membrane compartment organization
85. Of yeast, mice, and men. Rab proteins and organelle transport
86. Rab27a regulates the peripheral distribution of melanosomes in melanocytes
87. Rab1 interaction with a GM130 effector fomplex regulates COPII vesicle cis-Golgi tethering
88. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner
89. Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins
90. Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins